Kugwiritsa ntchito cellulose ether m'matumbo otentha

Joseph Brama adapanga zotamalidwa kuti apangitse mapaipi otsogolera kumapeto kwa zaka za m'ma 1800. Sipanafike mpaka pakati paukadaulo wa m'ma 1900 womwe ukadaulo wosungunuka uja unayamba kugwiritsidwa ntchito pazambiri za plastics. Inali kugwiritsidwa ntchito koyamba popanga ma poitring zokutira pamawaya maaya. Masiku ano ukadaulo wotentha wopitilira sugwiritsidwa ntchito osati popanga zinthu za polymer, komanso kupanga ndikusakaniza maudindo omwewo. Pakadali pano, oposa theka la zinthu zapulasitiki, kuphatikiza matumba apulasitiki, mapepala apulasitiki ndi mapaipi apulasitiki, amapangidwa pogwiritsa ntchito njirayi.

Pambuyo pake, ukadaulo uwu ukutuluka pang'onopang'ono mu gawo la pharmaceutical ndipo pang'onopang'ono unakhala ukadaulo wofunikira. Tsopano anthu amagwiritsa ntchito ukadaulo wopitilira muyeso kuti akonze ma granules, mapiritsi osuta, ma transmuucal ndi ma transmuucal centers etc. Chifukwa chiyani anthu amakonda ukadaulo uwu tsopano? Cholinga chake ndichakuti poyerekeza ndi zochitika zamwambo m'mbuyomu, ukadaulo wotentha wosungunuka uli ndi maubwino otsatirawa:

Sinthani kuchuluka kwa chilengedwe cha mankhwala osungunuka

Pali zabwino kukonza mapangidwe omasulidwa

Kukonzekera kwa gastroincastil othandizira omasuka

Sinthani kuwongolera kodabwitsa

Njira yokometsera imadziwika mu gawo limodzi

Tsegulani njira yatsopano yokonzekera ma misropulots

Pakati pawo, Ether Emal Emaiona gawo lofunikira munjira iyi, tiyeni tiwone kugwiritsa ntchito maleri athu ether.

Kugwiritsa ntchito ethyl cellulose

Ethyl cellose ndi mtundu wa hydrophobic ense cellulose. Mu gawo la pharmaceutical, tsopano amagwiritsidwa ntchito mu microencapsust ya zinthu yogwira, zotuluka komanso zopitilira muyeso, ma piritsi akukamba komanso ngati mikanda yoyendetsedwa ndi mapiritsi. Cellulose imatha kuwonjezera zolemera zosiyanasiyana. Kutentha kwake kagalasi ndi madigiri 129-133 Celsius, ndipo malo ake akulira akulira ndikuthadi madigiri 180 Celsius. Ethyl Cellose ndi chisankho chabwino chopenda chifukwa limawonetsa katundu wa thermoplac pamwamba pa kutentha kwake kwagalasi ndi pansi pa kutentha kwake.

Pofuna kutsitsa kutentha kwa galasi kwa ma polima, njira yodziwika bwino ndikuwonjezera mafayilo, kuti ithe kukonzedwa pamoto wotsika. Mankhwala ena amatha kukhala ngati mapiri, kotero palibe chifukwa chowonjezerapo mapulasitiki mukamagwiritsa ntchito mankhwala. Mwachitsanzo, zidapezeka kuti mafilimu otalika okhala ndi ibuprofen ndi ethyl cellulose anali ndi kutentha kwagalasi yotsika kuposa mafilimu omwe ali ndi ethyl cellose yekha. Makanema awa amatha kupangidwa mu labotale wokhala ndi ma twin ozungulira. Ofufuzawo amawoloka ufa kenako ndikuwunika. Zinapezeka kuti zikuchulukitsa kuchuluka kwa ibuprofen imatha kutsitsa kutentha kwagalasi.

Kuyesa kwinaku ndikuwonjezera ma hydrophilic a hydrophilic, hypomelfelose, ndi xanthan chingamu ku ethylcellulose ndi ibuprofen mitromatricys. Pamapeto pake kuti ma Micromatrix omwe amapangidwa ndi njira yopitilira muyeso anali ndi mayamwidwe ambiri kuposa malonda omwe akupezeka. Ofufuzawo adatulutsa micmaromatrix pogwiritsa ntchito kukhazikitsa kwa labotale ya labotale ndi ma twin-screwr otalika ndi cylindrical ya 3-MM. Ma sheet odulidwa manja anali 2 mm kutalika.

HyPromelfese

Hydroxypropyll methylcellulose ndi hydrophilic cellulose ether ether ether ether ether ether ethermose yowoneka bwino kapena yamitambo yolunjika ya colloidal yankho m'madzi ozizira. Njira yothetsera matendawa imakhala ndi zochitika zapamwamba, kuwonekera kwambiri komanso kusakhazikika. Solubilies imasiyanasiyana. Kutsitsa mamasukidwe, chachikulucho chosungunuka. Katundu wa hydroxypropyll methylcellulose yosiyanasiyana ndi yosiyanasiyana, ndipo zosinthika zake m'madzi sizikhudzidwa ndi mtengo wa pH.

M'makampani opanga mankhwala, nthawi zambiri amagwiritsidwa ntchito poyendetsa matrix olamulidwa, zomata zomata, etc. Kutentha kwake kwa ma hydroxygys, kutentha kwake ku Celsius kupitirira 250 Celsius. Chifukwa cha kutentha kwake kwagalasi kwamphamvu komanso kutentha kochepa kochepa, sikugwiritsidwa ntchito kwambiri m'matumbo osungunuka. Pofuna kukulitsa kuchuluka kwake, njira imodzi imangophatikiza pulurite yayikulu mu njira yopangira mawonekedwe monga momwe ophunzira awiriwo adanenera, ndikugwiritsa ntchito kusintha kwa matrix matrix omwe kulemera kwawo kwapulogalamuyi ndi osachepera 30%.

Ethylcellulose ndi hydroxypropymethycellulose imatha kuphatikizidwa m'njira yapadera pakupereka mankhwala. Chimodzi mwazinthu za mafomu awa ndikugwiritsa ntchito ethylclulose kuti chubu chakunja, kenako konzekerani kalasi ya hypomellose payokha. Cellulose pakati.

Kutulutsa kwa ethyllulose kumapangidwa pogwiritsa ntchito makina otentha mu labotale mu labotale poyitanitsa chubu cha chitsulo, cholumikizira chomwe chimapangidwa pamanja mpaka chimasungunuka. Zinthu zomwe zili pachimake zimadyetsedwa pamanja pa mapaipi. Cholinga cha kafukufukuyu chinali kuchotsa zotsatira za kutuluka komwe nthawi zina kumachitika mu hydroxypropyl ma mapiritsi a matrix. Ofufuzawo sanapeze kusiyana kwa ma hydroxypropyl wa ma vithylcellulose ya ma vithylcropyl, kusintha hydroxypropyl mankhwala omwe aperekedwa ndi methylcellulose yotulutsidwa mwachangu.

Kaonekedwe

Ngakhale kuti madzi otentha amasungunuka ndiukadaulo watsopano wamakampani opanga mankhwala, zakhudza chidwi kwambiri ndipo chimagwiritsidwa ntchito posintha mafomu ndi machitidwe osiyanasiyana. Tekinoloje yodzitayidwa ndi ukadaulo wotsogolera pakukonzanso zogawika kunja. Chifukwa mfundo zake zaukadaulo zimafanana ndi njira zambiri zokonzekera, ndipo zagwiritsidwa ntchito m'mafakitale ena kwazaka zambiri ndipo zakhala zokumana nazo zambiri, zimakhala ndi chitukuko chachikulu. Ndi kuyerekezera kafukufuku, akukhulupirira kuti ntchito yake idzakulitsidwa. Nthawi yomweyo, ukadaulo wosungunuka wosungunuka umalumikizana ndi mankhwala osokoneza bongo komanso kuchuluka kwa zochita. Pambuyo pa kusintha kwa malonda opangira mankhwala, amakhulupirira kuti kusandulika kwake kwa GMP kudzakhala mwachangu.