Cellulose eds ndi gulu la zotumphukira zam'madzi zosinthidwa ndi ma celluuse apamwamba monga kusungunuka kwamadzi abwino monga kusungunuka kwamadzi abwino monga kusungunuka kwamadzi abwino monga kusungunuka kwamadzi abwino monga kusungunuka, zomata, ndikugwiritsidwa ntchito kwambiri m'mafashoni. Chifukwa cha kudzitchinjiriza ndi chitetezo, cellulose eders zimagwira ntchito yofunika kukonzekera kwa mankhwala.
1. Zipangizo za Matax pakukonzekera kwa mamasulidwe
M'makampani opanga mankhwala, kukonzekera koyenera ndi kalasi ya kukonzekera kwa mankhwala osokoneza bongo omwe amachepetsa mphamvu mankhwala pogwiritsa ntchito mankhwala omasulira mankhwala. Cellulose, nthawi zambiri zimagwiritsidwa ntchito ngati zida zomasulira zovomerezeka chifukwa cha kukonzekera kwakuthupi komanso mankhwala. Hydroxypypyl methylcellulose (hpmc) ndi amodzi mwa cellulose yomwe imagwiritsidwa ntchito kwambiri. Itha kupanga gel m'madzi ndipo imatha kuyang'anira kumasulidwa kwa mankhwala osokoneza bongo. Mwa kusintha ma viutice, kuchuluka kwa zolowa m'malo mwa ma cellulose mu kukonzekera, mapangidwe a mankhwalawa amatha kusintha ngati pakufunika. Izi zimapangitsa kuti cellulose ikhale ndi zinthu zoyenera matrix pazokha kuti zisungunuke, zimasulidwa ndikukonzekera kumasulidwa.
2. Matebulo a piritsi
Pakupanga mapiritsi, cellulosesese yokhazikika imatha kugwiritsidwa ntchito ngati matchire kuti awonetsetse kufalikira kwa mankhwala osokoneza bongo ndi mphamvu yamapiritsi. Makamaka mu groin growulation njira, sodium carboxymethyl cellulose (cmc-n Kuphatikiza apo, kugwiritsa ntchito cellulose kumapiritsi kumathandizanso kusokonezedwa mapiritsi, kuti mankhwalawa amatha kumasulidwa mwachangu m'thupi ndikuwongolera bioavailability.
3. Makanema ophatikizika
Cellulose eders amagwiritsidwa ntchito kwambiri pamapiriki. Monga mawonekedwe ophatikizika, hydroxypylpyl methylcellulose ali ndi katundu wabwino wamakanema ndipo amatha kukonza bwino kukhazikika, kukana ndi mawonekedwe a mapiritsi a mankhwala osokoneza bongo. Mafilimu a Eleulse Ether amathanso kuchedwetsa kumasulidwa kwa mankhwalawa kuti athe kumasulidwa kapena kulowa. Kuphatikiza apo, pophatikiza cellulose eds ndi zigawo zina, zokutira ndi ntchito zosiyanasiyana zitha kukhazikitsidwa, monga zokutira zomasulidwa mwachangu, zokutira zoletsedwa, etc., kuti mukwaniritse zosowa za mankhwala osiyanasiyana.
4. Otsatsa ndi okhazikika
Mu kukonzekera kwamadzi, emulsions ndi kuyimitsidwa, cellose yokhazikika imagwira ntchito yofunika kwambiri monga kukula ndi okhazikika. Itha kuwonjezera mawidwe a yankho ndikusintha kuyimitsidwa kwa mankhwalawa, ndikuwonetsetsa kuti pali kufanana komanso kukhazikika kwa mankhwalawa. Mwachitsanzo, mu ophthalmic kukonzekera ndi kuyimitsidwa pakamwa, sodium carboxymethyl cellulose monga kukula kwamphamvu kumatha kukonza zotsatsa komanso kukhazikika kwa mankhwalawa pakugwiritsa ntchito. Kuphatikiza apo, cellulose etrers zimachita bwino pankhani ya midzi ndi kuopsa, ndipo musayambitse kukwiya kapena matupi awo sagwirizana, omwe amawapangitsa kugwiritsidwa ntchito kwambiri ku Ophthalmic mankhwala.
5. Zipangizo za makoma a kukonzekera kapisole
Cellulose eder amathanso kugwiritsidwa ntchito ngati zida zam'manja zokonzekera kapisole, makamaka pokonzekera kumera. Zida za khoma lachikhalidwe zimaphatikizapo gelatin makamaka gelatin, koma ndi kuchuluka kwa masamba ndi anthu osakirana, kufunikira kwa zinthu za makapisole kuchokera ku magwero azomera pang'onopang'ono. Te cellulose monga hydroxypropyll methylcellulose akhala gawo lofunikira pa makapisozi opangidwa ndi mbewu. Kapisozi ka kapisozi kamene kamangokhala ndi mphamvu zabwino, komanso amapereka mphamvu zamakina ndikukhazikika makapisozi a gelatin, kukwaniritsa zosowa za masamba komanso anthu osokoneza bongo.
6. Kukonzekera kwa pakamwa komanso zapamwamba
Cellulose agwiritsidwanso ntchito kwambiri pokonzekera pakamwa komanso wapamwamba. Chifukwa cha zotsatsa zake zabwino komanso zopanda pake, cellulose eder imatha kupanga filimu yoteteza pakamwa kapena khungu, limapititsa nthawi yosunga mankhwala osokoneza bongo pamalopo. Mwachitsanzo, mapiritsi owonongeka pakamwa, mafuta ndi mafuta onunkhira, cellulose, amathanso kugwira ntchito yabwino monga zonyamula mankhwala ndikuwonjezera mphamvu za mankhwala osokoneza bongo.
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Cellulose ether amathanso kugwiritsidwa ntchito pomanga mankhwala osokoneza bongo komanso magwiridwe a mankhwala osokoneza bongo. Pokonzekera microcapsules kapena nanoparticles, cellulose eder nthawi zambiri imagwiritsidwa ntchito ngati zida zakhoma kapena zonyamula kuti zithetsedwe, kumasulidwa ndipo ngakhale ndikukangana ndi mankhwala osokoneza bongo. Mwachitsanzo, hydroxypropyl methylcellulose ndi carboxymethyl cellulose imagwira gawo lofunikira pokonza mankhwala othamanga a microencaphsecsted kwa nthawi yayitali. Cellulose ede samangoteteza mankhwala osokoneza bongo ku zotsatira za m'mimba, komanso amathandiziranso nthawi yokwanira mankhwala m'thupi pokonzanso makina kumasulidwa.
Cellulose Eder amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, kuphimba minda yosiyanasiyana yokonzedwa bwino, mabatani, etc. Ndi chitukuko mosalekeza mwa ukadaulo wamankhwala ogwiritsa ntchito mankhwalawa, kugwiritsa ntchito kwa cellulose kukhala kukulitsidwanso, makamaka m'minda yatsopano yotumiza mankhwala, mankhwala osokoneza bongo ndi biomedicine, cellulose yopitilira idzapitiriza kuchita mbali yofunika.
Post Nthawi: Feb-17-2025