Hydroxypropyl methylcellulose (hpmc) ndi HyPromellose ndi mawu omwe nthawi zambiri amagwiritsidwa ntchito mosiyanasiyana, koma amatanthauza chinthu chomwecho. HPMC ndi chochita kupanga cha cellulose, ndipo hypromellose ndi dzina lopanda lamulo (loti la Inn) la patunduwu. Mawu awa nthawi zambiri amagwiritsidwa ntchito m'mafakitale a mankhwala ndi chakudya, pakati pa ena, chifukwa cha zinthu zawo zosiyanasiyana.
Hydroxypropyl methylcellulose (HPMC) / HyPromellose:
Hydroxypypyl methylcellulose ndiwosintha cellulose polymer. Kusintha kumaphatikizapo kuwonjezera kwa hydroxypyl ndi methoxy magulu am'madzi am'madzi. Cellulose ndi polysar mwachilengedwe chifukwa cha mayunitsi a glucose olumikizidwa ndi β-1,4-glycosiidic. Kukhazikitsidwa kwa hydroxypropyl (-och2ch (oh) ch3) Magulu a methoul (-och3) amapereka ma cellulose, kukulitsa kususuka kwake, kumalimbikitsa kusungunuka kwake.
Mulingo wa zolowa m'malo (DS) amatanthauza kuchuluka kwa magawidwe am'madzi pa anilroglucose mu unyolo wapanjala. Pankhani ya HPMC, kusiyanasiyana mu DS kumatha kuchititsa magiredi osiyanasiyana ndi zinthu zosiyanasiyana, kuwapangitsa kukhala ndi zinthu zosiyanasiyana pamapulogalamu osiyanasiyana.
Makhalidwe a Hydroxypropyll Methylcelulose:
Solity ndi gel opanga:
HPMC imasungunuka m'madzi pamtunda wotentha, ndipo kusungunuka mosungunuka zimatengera zinthu monga kuchuluka kwa kulowetsa kapena kunenepa kwambiri. Kukhalapo kwa hydroxypyll ndi methoxy m'magulu ake kumadzi ozizira, kupangitsa kukhala koyenera kugwiritsa ntchito mitundu yosiyanasiyana.
Makulidwe:
Chimodzi mwazinthu zofunikira za HPMC ndi kuthekera kwake kusintha mafayilo a yankho. Magawo osiyanasiyana a hpmc okhala ndi ma viscosties osiyanasiyana amapezeka kutengera zofunikira mwatsatanetsatane.
Kanema wopanga katundu:
HPMC imapanga makanema omveka bwino komanso osinthika, ndikupangitsa kuti ikhale yofunika kwambiri yogwirizanitsa m'mafakitale a mankhwala ndi chakudya. Katundu wopanga mafilimu ndiwofunikira kwambiri pakupanga mitundu yolimba ya mkamwa ndi kuphatikizika kwa confectionery.
Khazikitsani:
HPMC imawonetsa kukhazikika pamlingo waukulu wa ph sh, umathandizira pakusintha kwake mosiyanasiyana. Imatsutsa kuwonongeka kwa enzymatic ndi tizilombo tating'onoting'ono, kuonetsetsa kukhazikika kwa zinthu zamankhwala.
Mapulogalamu a mankhwala:
Piritsi lokutidwa:
HPMC imagwiritsidwa ntchito kwambiri makampani opanga ma piritsi. Zofukiza filimu imatumikira osiyanasiyana, kuphatikizapo kukoma kwa mafupa, kuteteza mankhwala opatsirana ndi zinthu zachilengedwe, komanso kuwongolera kumasulidwa.
Kukonzekera kotulutsidwa:
Kulamulidwa ndi kumasulidwa kwa mankhwala ndi gawo lofunikira la kukula kwa mankhwala. HPMC imagwiritsidwa ntchito kupanga ma matrix matrix omwe amalola kumasulidwa pang'onopang'ono kwa zopangira (apis) kwa nthawi yayitali.
Kukonzekera kwa ophthalmic:
Mu ophthalmic kapangidwe kake, HPMC imagwiritsidwa ntchito kuwonjezera mafayilo am'maso ndi nthawi yayitali yolumikizana ndi ocular. Izi zimathandizira kuchiritsa kwa mankhwalawa.
Pambapa komanso zosinthasintha:
HPMC imaphatikizidwa ndi mapangidwe apamwamba ngati ma gels ndi mafuta kuti ipereke mafayilo ndikusintha kufalitsa mankhwala. Amagwiritsidwanso ntchito m'magulu am'madzi kuti athetse kumasulidwa kwa mankhwala kudzera pakhungu.
Madzi amkamwa:
Hydroxypropyll methylclulose imagwiritsidwa ntchito popanga mafomu amkamwa pamlomo kuti apititse ma virus, kuyimitsa tinthu tating'ono, ndikusintha.
Makampani ogwira ntchito:
Thickener:
HPMC imagwiritsidwa ntchito ngati wothandizira wambiri muzakudya zosiyanasiyana, kuphatikizapo msuzi, zovala ndi zakudya. Kutha kwake kusintha ma viruyo kumathandiza kuti chinthu chomaliza chikwaniritse mawonekedwe omwe mukufuna.
Thickener:
Muzakudya zina za zakudya, hpmc zimatha kukhala ngati wothandizila, kuthandiza kupanga ma gels kapena kukhazikika kwa emulsions.
Galasi ndi zokutira:
HPMC imagwiritsidwa ntchito mu chakudya glazes ndi zokutira kuti zithandizire modekha, mawonekedwe ndi chinyezi. Amapanga filimu yowonekera yomwe imathandizira chidwi cha zakudya.
Kusintha Mafuta:
Monga hydrocoolloid, hpmc imatha kugwiritsidwa ntchito ngati mafuta opangira mafuta operewera kapena mafuta operekera, kupereka mapangidwe ake komanso pakamwa zofanana ndi zinthu zopangidwa ndi mafuta apamwamba.
Zovuta ndi Maganizo:
Pomwe hydroxypypyl methylcellulose ndizinthu zofananira ndi ntchito zosiyanasiyana, pali zovuta zina pakugwiritsa ntchito:
Kukhuta kutentha:
Kusungunuka kwa HPMC kumakhudzidwa ndi kutentha. Maphunziro ena amatha kuwonetsera kuchepetsa kuchepa kuchepetsedwa kutentha kwambiri, kufunikira kusamala mosamala mapangidwe.
Hygroscopicity:
HPMC ndi Hygroscopic, kutanthauza kuti imatenga chinyezi kuchokera kuchilengedwe. Katunduyu amafunika kuganiziridwa mwa kupanga zinyezi kuti ndizofunikira kwambiri.
Kugwirizana kwa Polic-Polymer:
M'mapulogalamu opanga mankhwala, kusiyanasiyana pakati pa mankhwala ndi polymer ndikofunikira kuonetsetsa kukhazikika ndi kufunikira kwa chinthu chomaliza.
Udindo Wowongolera:
Hydroxypropyl wakhala wolandiridwa kwambiri ndipo amavomerezedwa ndi mabungwe owongolera monga chakudya cha US ndi mankhwala osokoneza bongo (FDA) ndi European Mankhwala a bungwe (EMA). Linalembedwa mu pharmacopoeia monga ozindikiritsidwa pakukonzekera kwa mankhwala.
Hydroxypropyl methylcellulose, yomwe imadziwika kuti hypromellose, ndi polymer yosiyanasiyana yokhala ndi mafakitale osiyanasiyana. Malo ake apadera, kuphatikizapo kususuka, kusinthasintha kwa magazi, kuthekera kwamafilimu komanso kukhazikika, zimapangitsa kukhala chofunikira kwambiri mu mitundu yosiyanasiyana.
Kuchokera ku ma piritsi ndikutulutsa mapangidwe omasulidwa mu mabatani okutira ndi mafuta ogwiritsira ntchito mankhwala ogulitsa zakudya, HPMC imachita mbali yofunika kwambiri yolimbikitsira ntchito ndi zinthu zingapo. Kutha kuwongolera katundu wake posintha digiri ya kulowetsedwa ndi ma molecular kulemera kumathandizira kusinthasintha kwa kusintha kwake.
Post Nthawi: Feb-19-2025