Hard Capsules / HPMC Hollow Capsules / Masamba Mapulogalamu a Masamba / Njira Yokwera Kwambiri API ndi Chinyezi Kusakaniza / Mafilimu Omasulira / OSD Injiniya ....
Kugwiritsa ntchito bwino kwambiri, kuwononga ndalama, kumasuka kwa kuwongolera kwa Mlingo, miyeso yolimba pakamwa (OSD) malonda omwe amakonda kwambiri opanga mankhwala opanga mankhwala.
Mwa mabungwe a 38 ang'onoang'ono (nmes) ovomerezeka ndi chakudya cha US ndi mankhwala osokoneza bongo mu 2019, 26 anali OSD1. Mu 2018, msika wa zinthu zolembedwa ndi ma cmos pamsika waku North America unali pafupifupi $ 19 biliyoni mu 20243.
Mapiritsi amalamulirabe msika womwe wasd, koma makapisozi olimba akukhala njira yowoneka bwino. Izi ndizofunikira chifukwa chodalirika kwa makapisozi monga njira yoyendetsera, makamaka iwo omwe ali ndi Mutu wambili wambili. Makapisozi amakonda kwambiri odwala, maski osasangalatsa ndi zonunkhira komanso zokonda, ndipo ndizosavuta kumeza, kwakukulu kuposa mitundu ina.
Nyali yachitsulo, manejala othandizira ku Lonzake ndi zosakaniza zaumoyo, amafotokoza zabwino zosiyanasiyana pamapiritsi. Amagawana zinthu zake mu hydroxypropyl methylcellulose (hpmc) makapisozi ndi momwe angathandizire opanga mankhwala opanga mankhwala atakumana ndi mankhwala ogula a mankhwala ogulitsidwa.
Makapisozi ovutikira: Sinthani potsatira wodwala ndikutha kuchita
Odwala nthawi zambiri amalimbana ndi mankhwala omwe amalawa kapena kununkhira bwino, ndizovuta kumeza, kapena kungakhale ndi zovuta. Ndi izi m'malingaliro, kukulitsa mitundu yosangalatsa ya ogwiritsa ntchito ikhoza kusintha kuleza mtima kuwongolera chithandizo chamankhwala. Makapisozi olimba ndi njira yokongola kwa odwala chifukwa, kuwonjezera pa kukoma kwa mabotolo ndi fungo, kumachepetsa mapiritsi, ndipo amakhala ndi nthawi yomasulidwa, kumasulidwa, kumasulidwa ndikumasulidwa.
Kuwongolera mayendedwe omasulidwa a mankhwalawa, mwachitsanzo pobisalira api, imatha kupewa kuchepa kwa mlingo ndikuchepetsa zotsatira zoyipa. Opanga mankhwala osokoneza bongo akupeza kuti kuphatikiza ukadaulo wokhala ndi makapisozi amawonjezera kusinthasintha ndi kugwira ntchito kwa preces-yotulutsidwa. Itha kuthandizira ngakhale ma pellets okhala ndi kapisole yemweyo, zomwe zikutanthauza kuti mankhwala ambiri amatha kutumikiridwa nthawi yomweyo Mlingo wosiyanasiyana, kuphatikiza pafupipafupi dosing.
Makhalidwe a pharmacokinetic ndi pharmacondynamic mwa mitundu iyi, kuphatikizapo kuchulukitsa kachitidwe ka 2
Ndi chifukwa cha kusintha kumeneku mwakuleza mtima ndi kutsimikizira kuti kufunikira kwa msika wa granilar wolowa m'malo movutikira kumapitilirabe kukula.
Kukonda kwa Polymer:
Kufunika Kwa Mapapu a Masamba a Masamba Kuti Alowe M'mapisozi Zolimba za Gelatin
Makapisozi ogwirira ntchito molimbika amapangidwa ndi gelatin, komabe, makapisozi olimba amatha kukhalapo zovuta mukakumana ndi vuto la hygroscopic kapena chinyezi. Gelatin ndi chinthu chopangidwa ndi nyama chomwe chimakonda kugwirizanitsa cholumikizirana cholumikizirana cholumikizira chisinthiko, ndipo chimakhala ndi madzi ambiri kuti asinthe, koma amatha kusinthanso madzi ndi apis komanso osafunikira.
Kuphatikiza pa mphamvu ya kapisozi pa ntchito, odwala ambiri safuna kugwiritsira ntchito zinthu zachilengedwe pazifukwa zachikhalidwe kapena chikhalidwe ndipo amafufuza mankhwala odzala. Kuti akakwaniritse chosowa ichi, makampani opanga mankhwala akupitilizabe kuyikanso ndalama zatsopano zomwe zimapangidwa ndi njira zina zomwe zili zotetezeka komanso zothandiza. Kupita patsogolo kwa Zipangizo za Sayansi zapangitsa kuti zipilala zabzala zablew zomwe zabzala, zomwe sizingafanane ndi mavalidwe a gelatin kuphatikiza, kusavuta kupanga, komanso kugwiritsa ntchito mtengo.
Kutha kwabwino ndi kulingana:
Kugwiritsa ntchito HPMC
Pakadali pano, chimodzi mwa njira zabwino kwambiri ku gelatin ndi hydroxypropyl methylcellulose (hpmc), polymer achokera ku ulusi wa mtengo.
HPMC siing'ono kwambiri kuposa gelatin komanso imatenga madzi ochepa kuposa gelatin6. Madzi otsika a HPMC Capsules amachepetsa kusinthana kwa madzi pakati pa kapisozi ndi zomwe zilipo, zomwe nthawi zina zimatha kusintha moyo wa kusinthasintha, ndikuthana ndi zovuta za hygroscopic apis ndi zokomera. Makapisozi a HPMC Showlow samakhala osasamala kutentha komanso kusavuta kusunga ndi kunyamula.
Ndi kuchuluka kwa apis okwera kwambiri, zofunikira pakupanga zikuyamba kukhala zovuta kwambiri. Pakadali pano, opanga mankhwala osokoneza bongo akwanitsa zotsatira zabwino kwambiri pakufufuza kugwiritsa ntchito makapisozi a HPMC kuti alowe mapiritsi achikhalidwe a Gelatin. M'malo mwake, makapisozi a HPMC pakadali pano amakonda kumayesedwa azachipatala chifukwa chogwirizana kwambiri ndi mankhwala ambiri komanso osadziwa bwino.
Kupitiliza kusintha kwaukadaulo wa HPMC kapisozi kutanthauzanso kuti opanga mankhwala ali ndi mwayi wogwiritsa ntchito magawo ake komanso kuphatikizidwa ndi mitundu yosiyanasiyana yamphamvu, kuphatikizapo mankhwala osiyanasiyana.
Makapisozi a HPMC Popanda kuphatikizidwa kukhala ndi zosinthika zabwino popanda ion ndi kudalira komweko, kotero kuti odwala apanga zochizira zomwezo popanda kumwa kapena kudya. Monga zikuwonekera pa Chithunzi 1. 8
Zotsatira zake, kusintha komwe kumatha kuwononga kungalolere odwala kukhala opanda choyenera pokonzanso Mlingo wawo, potero.
Kuphatikiza apo, kupitiriza kwatsopano ku HPMC Capsule Membrane mayankho amathanso kuteteza chitetezo cha m'mimba, ndikuwonjezeranso ntchito zomwe zingachitike pa mapiritsi a HPMC.
Njira ina yogwiritsira ntchito makapisozi a HPMC ili m'magawo am'mapapo a m'mapapo. Kutha kwa msika kukupitilizabe chifukwa chofuna kusintha kwa bioavailar popewa njira yolunjika yothandizira mukamayendetsa matenda monga mphumu zosokoneza bongo.
Opanga mankhwala osokoneza bongo nthawi zonse amawoneka kuti akupeza chithandizo chopatsa thanzi, komanso chokwanira chothandizira kupuma matenda, ndikufufuza chithandizo choperekera mankhwala osokoneza bongo chifukwa cha matenda am'mimba (CNS) matenda. Kufuna kukuwonjezereka.
Madzi otsika a makapisozi a HPMC amawapangitsa kukhala abwino kwa hygroscopic kapena matenda am'madzi, ngakhale magetsi apakati pakati pa kapangidwe kake ndi makapisozi ayeneranso kuganiziridwanso mwachitukuko.
Maganizo Omaliza
Kukula kwa Membrane sayansi ndi usune waukadaulo wayala maziko a makapisozi a HPMC kuti abwezeretse makapisozi amakonzekereratu. Kuphatikiza apo, kukulitsa zokhumba zokonda za ogula ndikuyika kufunikira kwa mankhwala otsika mtengo omwe athandizira makapisozi a Holloolow Compsules ndi mamolekyulu onyozeka.
Komabe, kusankha kwa member zinthu ndi njira yofunika kuonetsetsa kuti zinthu zikuyendere bwino ntchito, komanso kusankha koyenera pakati pa Gelatin ndi HPMC ikhoza kupangidwa ndi ukadaulo woyenera. Kusankha koyenera kwa membrane sikungakuthandizeni bwino komanso kuchepetsa mavuto, komanso amathandizira kuthana ndi zovuta zina zopanga.
Post Nthawi: Feb-20-2025