Kusungunuka kwa hydroxypropyl methylcellulose (hpmc, hydroxypropyll methylcellulose) imakhudzidwa ndi zinthu zambiri, zosungunulira zake, zosungunulira ndi malo akunja. Zinthu izi ndizofunikira kwambiri pakugwiritsa ntchito HPMC ndi ntchito yake mu mankhwala ogulitsa, chakudya, zomanga ndi mafakitale ena.
1. Mankhwala akuthupi ndi mankhwala
1.1 zolemera
Kulemera kwa HPMC ndi chinthu chofunikira kwambiri chokhudza kuchepetsedwa kwake. Nthawi zambiri, chokulirapo kunenepa, pang'onopang'ono kuchuluka kwa chilengedwe. Izi ndichifukwa choti kulemera kokulirapo kumabweretsa unyolo wautali, zomwe zimawonjezera kukomoka ndi kuyanjana pakati pa mamolekyulu, potero kuchepetsa kusungunuka. M'malo mwake, hpmc yokhala ndi kulemera kocheperako kumasungunuka mwachangu, koma njira yake imatha kukhala yotsika, ndikupangitsa kuti isakhale yoyenera pamapulogalamu ena.
1.2 digiri yapansi
Mulingo wa zolowa za HPMC (mwachitsanzo, kuchuluka kwa kulowetsa methoxy ndi hydroxyprophoroxy magulu) amakhudzanso kusandulika kwake. HPMC yokhala ndi digiri ya methoxy ndi hydroxyprophoroxy imakonda kukhala yosungunuka bwino m'madzi chifukwa izi zimapangitsa kuti ma molekyu a molekyusi ndikulimbikitsa hydration. Komabe, cholowa kwambiri chimatha kutsika mu kusungunuka kwa HPMC m'miyeso ina ya ma sol sol, yomwe ikukhudzana ndi polarity ya zosungunulira ndi kusamalira zochitika.
1.3 kukula kwa tinthu
Tizilombo tating'onoting'ono ya hpmc imakhudza kwambiri kuchuluka kwake. Zocheperako kukula kwa tinthu, chachikulu pamalo ena apadera pa voliyumu iliyonse, ndipo malowo omwe apezeka ndi zosungunulira, potero ufulumiza kusunthira. Chifukwa chake, HPMC mu mawonekedwe a ufa yabwino nthawi zambiri imasungunuka mwachangu kuposa mawonekedwe a glanur.
2. Mikhalidwe yosungunulira
2.1 chosungunulira
Kusungunuka kwa HPMC kumasiyana kwambiri m'matumbo osiyanasiyana. HPMC ili ndi kusungunuka bwino m'madzi, makamaka madzi ofunda. Zosasinthika monga ethanol, ma propylene glycol, ethylene glycol, etc. imathanso kusungunula hpmc, koma kusungunuka mwachangu ndi kusungunuka nthawi zambiri kumakhala kotsika kuposa madzi. Posinthanitsa ndi zinthu zosungunulira, kusungunuka kumadalira kuchuluka kwa zigawo zikuluzikulu ndi kuyanjana kwawo ndi HPMC.
2.2 kutentha
Kutentha kumakhudza kwambiri kusungunuka kwa HPMC. Nthawi zambiri, ma hpmc amasungunuka pang'onopang'ono m'madzi ozizira, koma pamene kutentha kumawonjezeka, kuchuluka kwa chilengedwe kumachuluka kwambiri, ndipo kumachita bwino kwambiri m'madzi ofunda a 40-50 ° C. Komabe, kutentha kwambiri (nthawi zambiri kumatentha 70 ° C), hpmc kungapangitse kapena kupanga gel, komwe kumakhudzana ndi kusintha kwa thermodynamic ndi njira yothetsera vuto.
2,3 pH mtengo
Kusungunuka kwa HPMC kumakhala kokhazikika pansi pa pH yosiyanasiyana ya pH, koma mikhalidwe yamphamvu kwambiri (monga acid a acid kapena alkali) imatha kukhudza kusoka kwake komanso kukhazikika. HPMC nthawi zambiri imakhala ndi solubility yabwino kwambiri yotsika kapena yosalowerera.
3. Zinthu zakunja zakunja
3.1 Zovuta Zosangalatsa
Liwiro losangalatsa ndi njira zimakhudza kwambiri liwiro lophweka la HPMC. Kukhazikika koyenera kumatha kulimbikitsa kulumikizana pakati pa HPMC ndi zosungunulira kuti tipewe mapangidwe a clumps, potero itangoletsani kusungunuka. Otukuka mwachangu angayambitse thovu kuti apange mawonekedwe, akukhudza kufanana kwa yankho.
3.2 zowonjezera
Zina zowonjezera mu yankho, monga mchere, ma elecrolyte, magetsi, soloni, etc., idzakhudza kusungunuka kwa HPMC. Mwachitsanzo, mchere wina uliwonse ungalimbikitse kufalikira kwa HPMC, pomwe woipa kwambiri wama electrolyte amatha kuyambitsa mpweya kapena kusintha kwa ma hpmc. Kuphatikiza kwa ogwiritsa ntchito amatha kusintha solubility ya HPMC m'malo ena osasunthika ndikukhazikitsa magwiridwe antchito.
4. Malingaliro a ntchito
4.1 Makampani ogulitsa mankhwala
M'makampani opanga mankhwala, HPMC imagwiritsidwa ntchito kwambiri ngati nkhani yokonza matrix pakukonzekera kutukuka, ndipo kusungunuka kwake mwachindunji kumakhudza kuchuluka kwa kusungulumwa ndi bioavailability wa mankhwalawa. Chifukwa chake, kuwongolera kunenepa kwambiri, kuchuluka kwa malo osokoneza bongo ndi kusungunuka kwa HPMC ndikofunikira pakukonzekera kokwanira komanso kukonzekera kwamankhwala.
4.2 Makampani Ogulitsa Zakudya
M'makampani azakudya, HPMC imagwiritsidwa ntchito ngati thickener, ribiface ndi emulsifier. Kusungunuka kwake kumatsimikizira kubalalitsidwa, kapangidwe ndi kukhazikika mu chakudya. Posintha zisudzo, kugwiritsa ntchito kwa chakudya kwa HPMC kumatha kuthandizidwa.
4.3 Makampani Omanga
Pomanga zida, HPMC imagwiritsidwa ntchito ngati wothandizira wamadzi, wokulirapo ndi binder, ndipo kusungunuka kwake kumakhudza mapangidwe ake opanga ndi matope omaliza. Kusintha mikhalidwe yosungunuka ndi njira zogwiritsira ntchito ku HPMC kumatha kukulitsa kugwiritsa ntchito mogwirizana ndi kukhazikika kwa nkhaniyi.
Kusungunuka kwa HPMC kumakhudzidwa ndi zakuthupi ndi mankhwala monga kulemera kwa ma celecular, ndi kukula kwa mikhalidwe, kutentha, komanso zinthu zakunja. Pamapulogalamu othandiza, kusungunuka kosungunuka kwa HPMC kumatha kukhazikitsidwa moyenera posankha bwino ndi kuwongolera zinthu izi molingana ndi zofunikira zina. Kuzindikira mwakuya kwa zinthuzi kudzakuthandizani kukonza mafakitale osiyanasiyana ndikuthandizira kusankhana ndi ukadaulo m'minda yofananira.
Post Nthawi: Feb-17-2025