Zinthu Zomwe Zimakhudza Makulidwe a HPMC

Hydroxypyl methylcellulose (hpmc) ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito kwambiri m'minda yomanga, mankhwala ndi zodzola komanso zodzola. Makulidwe a HPMC ndi amodzi mwa zizindikiro zake zazikulu chifukwa zimakhudza mwachindunji madzi, zomwe zimaphatikizidwa, gel katundu ndi zinthu zina mwazinthuzi. Chifukwa chake, kumvetsetsa zinthu zomwe zikukhudza mafayilo a HPMC ndikofunikira kuti mugwiritse ntchito ndi kapangidwe kazinthu m'magawo osiyanasiyana.

1. Zotsatira za ma culecular kulemera
Kulemera kwa HPMC kumakhudza kwambiri mafayilo. Chokulirapo kunenepa kwambiri, mafayilo apamwamba a yankho. Izi ndichifukwa choti HPMC yokhala ndi kulemera kwakukulu kwa ma molecular yovuta kwambiri mu yankho, zomwe zimawonjezera kusokonekera kwa yankho ndikuwonjezera kuwonjezeka kwa mamasukidwe. Nthawi yomweyo, kulemera kwakukulu kumayambitsa kusintha kwamphamvu kwa njira yothetsera njira yomwe ikuyenda, yomwe ndiyofunika kwambiri kuti mubwezeretse magwiridwe antchito, omata ndi ntchito zina. Maphunziro onse oyesera komanso owoneka bwino awonetsa kuti mawonekedwe a ma visc komanso molecy kulemera mwamphamvu kuwonetsa mgwirizano wamagetsi, ndiye kuti, ma viscy samachulukitsa ngati kulemera kwa ma celecular.

2. Mphamvu ya kuchuluka kwa zolowa m'malo
Mulingo wazolowa m'malo mwa hydroxypropyl (-ch3chochcypyl (-ch3chochyp2-) ndi methyl (-ch3) magulu ku HPMC ndi chinthu chofunikira kwambiri. Mulingo wazolowa m'malo mwa magulu a hydroxyl (-Oh) pa HPMC Molecular Ttanit ndi Hydroxypyl ndi Magulu a Methyl. Pamene kuchuluka kwa mitundu ya hydroxypyl kumawonjezeka, kulumikizana pakati pa zilonda za HPMC molecular kumafooketse, ndipo unyolo wamatumbo amakhala osavuta kukulitsa yankho la madzi, potero akuwonjezera mamasukidwe a yankho; Ngakhale kuwonjezeka kwa magulu a methyl kumakulitsa hydrophobicity ya yankho, chifukwa chosungunuka kumatsika, potengera kukweza mafayilo. Nthawi zambiri, hpmc yokhala ndi gawo lalikulu la cholowa chamtunduwu limakhala ndi solubility ndi mafakisoni, ndipo amatha kukwaniritsa zosowa za minda yosiyanasiyana.

3. Zotsatira za njira yosinthira
Makutu a HPMC yankho limagwirizana kwambiri ndi ndende yake. Pamene kuchuluka kwa yankho kumawonjezeka, kulumikizana pakati pa mamolekyu kumachuluka kwambiri, kumapangitsa kuti mamasukidwe athetse chidwi. Pamtundu wotsika, mamolekyulu a HPMC alipo mu mawonekedwe a unyolo kamodzi, ndipo chidwi chake chimasintha bwino; Pamene ndende itafika pamtengo wina wofunikira, ma molekyulu a HPMC adzagwirana ndikucheza wina ndi mnzake, ndikupanga ma network, ndikupangitsa ma vinyayo kuti awonjezere mwachangu. Kuphatikiza apo, kuwonjezeka kwa yankho ndende kumayambitsa HPMC kuti iwonetsere kumeta ubweya, ndiye kuti, chidwi chimawonjezeka pansi pa ntchito yayikulu.

4. Kutengera mtundu wa mtundu
Mtundu wa zosungunulirali ndi chofunikira kwambiri pa solubility ndi mafayilo a HPMC. HPMC imatha kusungunuka m'madzi ndi ena osungunuka (monga methanol, ethanol, acetone), koma ma son sol solebiteice osiyanasiyana ndi osungunuka. M'madzi, hpmc nthawi zambiri amakhala ndi mawonekedwe apamwamba a ma viscction, pomwe mu organic sol amaonetsa ma victoni otsika. Polarity wa zosungunulirali ndi vuto lalikulu pakukweza kwa HPMC. Masungunuke okhala ndi polarity kwambiri (monga madzi) adzakulitsa hpmc mamolekyulu, potero akuwonjezera ufa wa yankho. Malo osakhazikika sangasungunuke kwathunthu hpmc, zomwe zimapangitsa kuti muwonetsetse ma visction otsika kapena kufalikira kosakwanira. Kuphatikiza apo, kusankha ndi kuchuluka kwa zosinthika zosungunulira kudzakhudzanso makamaka magwiridwe antchito a HPMC.

5.. Zotsatira za kutentha
Kutentha ndi imodzi mwazinthu zazikulu zachilengedwe zomwe zimakhudza mafayilo a HPMC. Nthawi zambiri, mafayilo a HPMC amachepetsa pamene kutentha kumawonjezeka. Izi ndichifukwa kutentha kwakukulu kumawononga maunyolo a hydrogen ndi njira zina pakati pa zisudzo za HPMC molecular, ndikupangitsa kuti maunyolo amaseka mosavuta, potengera ufawo wa yankho. Pamatha kutentha kwambiri, hpmc imatha kukhala miyala yokhazikika kuti apange mawonekedwe okhazikika a gel. Katundu wamafuta amoto uwu amagwiritsidwa ntchito kwambiri muzomangamanga ndi mafakitale omwe amapezeka chifukwa cha ufa woyenera komanso kuthandizidwa. Kuphatikiza apo, kutentha kumakhala ndi zovuta zosiyanasiyana pakuwoneka kwa HPMCS yokhala ndi zolemera zosiyanasiyana. Nthawi zambiri, ma hpmcs okhala ndi zolemera zazikulu zolemera komanso madigiriili okhazikika azolowa m'malo mwake amathandizira kusintha kwa kutentha.

6. Zotsatira za PH Mtengo
Ngakhale hpmc ndi polymer polymer ndipo nthawi zambiri imatha kusokonekera pama ph mikhalidwe yolimba (monga m'malo a acid acid kapena alkaline). Izi ndichifukwa choti malo a acid a asidi a alkali adzawononga kapangidwe ka HPMC ndikuchepetsa kukhazikika kwake, zomwe zimapangitsa kuchepa kwa mafakisi. Pa ntchito zina, monga kukonzekera kwa mankhwala am'madzi ndi zowonjezera za chakudya, ndizofunikira makamaka kuti ma viscty a HPMC ikhale yokhazikika mkati mwa mitundu yoyenera.

7. Mphamvu ya Ionic Mphamvu
Mphamvu ya Ionic mu yankho imakhudzanso kakhalidwe ka HPMC. Malo okwanira oidi okwera kwambiri adzatchinga milandu ya HPMC Molecular, kuchepetsa magetsi azomwezi, ndikupangitsa kuti zikhale zosavuta kwa ma unyolo opita, poyerekeza mawilo. Nthawi zambiri, pokonzekera macheza a HPMC am'madzi, ion ndende iyenera kulamulidwa kuti iwonetsetse mafayilo okhazikika, omwe ndikofunikira makamaka mu mankhwala opangira mankhwala komanso zodzikongoletsera.

Makulidwe a HPMC amakhudzidwa ndi zinthu zambiri, kuphatikizapo kunenepa, kuchuluka kwa kulowetsa, kusintha kwa mtundu, kutentha, kutentha, mphamvu ya ph ndi ionic. Kulemera kwa maselo ndi kuchuluka kwa kuloweza makamaka kumazindikira mawonekedwe a ma viscc a hpmc, pomwe zinthu zakunja monga njira yothetsera mavuto, kutentha kwa ma vinyayo pakugwiritsa ntchito. Pamapulogalamu othandiza, oyenera mitundu ya HPMC ndi mikhalidwe yolamulira imafunikira kuti isankhidwe molingana ndi zofunikira kuti akwaniritse magwiridwe antchito abwino. Kuyanjana ndi mfundozi kumatsimikizira magwiridwe antchito ndi minda yogwira ntchito ya HPMC, ndikuthandizira kuthandizidwa ndi ntchito yake pomanga, mankhwala opangidwa, chakudya ndi mafakitale ena.