Zinthu zomwe zikukhudza alumali moyo wa HPMC

Hydroxypropyl methylcellulose (hpmc) ndi mankhwala osokoneza bongo omwe nthawi zambiri amagwiritsidwa ntchito mu mankhwala, chakudya, zodzoladzola komanso zida zomangira. Moyo wake wa alumali amatanthauza kutalika kwa nthawi zitha kukhalabe ndi katundu wake wamankhwala, magwiridwe antchito ndi magwiridwe antchito. Zinthu zomwe zimakhudza moyo wa alumali wa HPMC zimaphatikizapo nyengo, malo osungirako, kukhazikika kwamankhwala, etc.

1. Zinthu zachilengedwe
1.1 kutentha
Kutentha ndi chimodzi mwazinthu zofunika zomwe zimakhudza alumali moyo wa HPMC. Kutentha kwakukulu kumathandizira kuwonongeka kwa HPMC, zomwe zimapangitsa kusintha muthupi ndi mankhwala ake. Mwachitsanzo, HPMC imatha kutembenukira chikasu ndikuchepetsa mafayilo akutentha kwambiri, akukhudza momwe amachitira bwino. Chifukwa chake, kutentha kozizira komwe HPMC yasungidwa kuyenera kusungidwa kutentha pang'ono, nthawi zambiri pansi pa 25 ° C Gawoli.

1.2 chinyezi
Mphamvu ya chinyezi pa HPMC ndiyofunikanso. HPMC ndi zinthu za hydrophilic zomwe zimamwa chinyezi mosavuta. Ngati chinyezi m'dera losungirako ndizambiri, hpmc chimatenga chinyezi mlengalenga, kupangitsa kuti ma vinyo azisintha, kusungunuka kwake kutsika, ndipo ngakhale kusonkhana kumachitika. Chifukwa chake, HPMC iyenera kuwuma ikasungidwa, ndipo tikulimbikitsidwa kuti wachibale uwongoleredwa pansi pa 30%.

2. Malo osungira
2.1
Zipangizo zopangira ndi kusindikiza kumakhudza kwambiri alumali moyo wa HPMC. Zipangizo zapamwamba kwambiri zimatha kudzipatula mpweya ndi chinyezi komanso kupewa hpmc kuti zisanyowe ndi kuwonongeka. Zida zomwe anthu ambiri amagwiritsa ntchito zimaphatikizapo matumba a aluminium a aluminium, etchthylene, etc., omwe ali ndi zotchinga zabwino. Nthawi yomweyo, malo osindikizidwa bwino amatha kuchepetsa kulumikizana kwa HPMC yomwe ili ndi malo akunja ndikuwonjezera moyo wake.

2.2 kuyatsa
Kuwala, makamaka kwa ultraviolet inradiation, kumatha kuyambitsa kuwonongeka kwa zithunzi za HPMC ndikusokoneza mphamvu zake zakuthupi ndi mankhwala. Tikaona kuwala kwa nthawi yayitali, hpmc imatha kusintha mtundu, kuwonongeka kwa unyolo, motero, HPMC iyenera kusungidwa m'malo owoneka bwino kapena gwiritsani ntchito zida za opaque.

3.. Kukhazikika kwa Mankhwala
3.1 PH mtengo
Kukhazikika kwa HPMC kumakhudzidwa kwambiri ndi mtengo wa pH. Pansi pa acidic kapena alkaline mikhalidwe, hpmc idzakumana ndi hydrolysis kapena kuwonongeka kwa zinthu, zomwe zimayambitsa mavuto monga kuchepa kwa mafakiti komanso kusintha kwa kusungunuka. Pofuna kuonetsetsa kukhazikika kwa hpmc, tikulimbikitsidwa kuti mtengo wa yankho lake uwongoledwe mkati mwazinthu zosalowerera (ph 6-8).

3.2 zosayera
Kukhalapo kwa zosayenera kumakhudza kukhazikika kwamphamvu kwa HPMC. Mwachitsanzo, zodetsa monga zitsulo zimatha kuthana ndi vuto la HPMC, kufupikitsa alumali moyo wake. Chifukwa chake, kudetsa kuyenera kulamulidwa mosamalitsa pakupanga ndi zinthu zoyera kwambiri kuyenera kugwiritsidwa ntchito kuonetsetsa kuyera kwa HPMC.

4.. Fomu Yogulitsa
Mtundu wa HPMC umakhudzanso moyo wa alumali. HPMC nthawi zambiri imakhalapo mu mawonekedwe a ufa kapena granules. Zomwe zimapangitsa mitundu yosiyanasiyana pa moyo wake ndi motere:

4.1 mawonekedwe a ufa
Fomu ya HPMC ili ndi malo akuluakulu ndipo imakhala ndi hygroscopic ndipo imayipitsidwa, moyo wake wa alumali amakhala wamfupi. Kuwonjezera moyo wa alumali wa ufa wa ufa wa HPMC, kusindikizidwa kuyenera kulimbikitsidwa kuti musalumikizidwe ndi mpweya ndi chinyezi.

4.2 tinthu tarphology
Zidutswa za HPMC zimakhala ndi malo ocheperako, ndizochepa kwambiri hygroscopic, ndikukhala ndi moyo wautali. Komabe, gpminated HPMC imatha kupanga fumbi nthawi yosungirako ndi mayendedwe, zomwe zimapangitsa kuti alumali aleke. Chifukwa chake, granalar hpmc imafunanso kunyamula bwino ndi malo osungira.

5. Gwiritsani ntchito zowonjezera
Pofuna kukonza bata ndikuwonjezera moyo wa alumali wa HPMC, okhazikika kapena oteteza zinthu amatha kuwonjezeredwa pakupanga. Mwachitsanzo, kuwonjezera ma antioxidalaralalalalalalalalalalalatesled kuwonongeka kwa hpmc, ndikuwonjezera othandizira chinyontho kumachepetsa hpmc. Komabe, kusankhidwa ndi kuchuluka kwa zowonjezera kumafunikira kuti zitsimikizidwe motsimikiza kuti zitsimikizire kuti sizikhudza ntchito ndi chitetezo cha HPMC.

Moyo wa alumali wa HPMC amakhudzidwa ndi zinthu zambiri, kuphatikizapo mikhalidwe yachilengedwe (kutentha, chinyezi), Kukhazikika), mawonekedwe a mankhwala (mawonekedwe), ma granules) ndikugwiritsa ntchito zowonjezera. Pofuna kuwonjezera alumali moyo wa HPMC, izi ziyenera kuganiziridwa bwino kwambiri komanso zoyenera ziyenera kutengedwa kuti zithetsedwe. Mwachitsanzo, khalani ndi malo owuma ndi owuma, owongolera njira ya PH, ndi zina mwanzeru.