Kodi HPMC imapereka bwanji mafayilo osasinthika?

Hydroxypropyl methylcellulose (hpmc) ndi ma cerulose osungunuka, osungunuka amadzi omwe amagwiritsidwa ntchito m'mafakitale osiyanasiyana monga mankhwala opanga, chakudya, zodzola komanso zomangamanga. Chimodzi mwazinthu zoyipa ndi kuthekera kwake kupereka mafayilo osasinthika pamatumba ndi mapangidwe. Makina kumbuyo kwa HPMC kuti ikhalebe yokhazikika komanso yosasinthika ndi imatha kumvedwa mwa kupenda kapangidwe kake, kuyanjana ndi madzi, komanso chikhalidwe chosiyana.

Kapangidwe kake ndi kusungunuka
HPMC imachokera ku cellulose, polymer yachilengedwe yopangidwa ndi zigawo za glucose yolumikizidwa ndi β-1,4-glycosidic. Njira yosinthitsa imaphatikizapo kuyambitsa methoxy ndi hydroxypyl magulu a cellulose a cellulose, chifukwa cha hydroxypropyllulose. Kusintha kumeneku kumawonjezera kusungunuka kwa HPMC m'madzi ndi okhazikika.

Mulingo wa zolowa m'malo (DS) ndi molar zowonjezera (ms) ndi magawo ofunikira omwe amafotokoza katundu wa HPMC. DS amatanthauza chiwerengero cha ma hydroxyl ophatikizidwa pa unit pa unit, pomwe MS imawonetsa kuchuluka kwa magulu am'magulu a anillerrogluc. Magawo awa amakopa kusungunuka kwa HPMC, kuwotcha katundu, komanso mafayilo.

Njira zamawu osinthana
Hydration ndi gel mawonekedwe:
HPMC ikawonjezeredwa kumadzi, imakhala hydcules, momwe mamolekyulu amadzi amalowera ndikucheza ndi maunyolo a polymer, ndikupangitsa kuti atupa. Njira yama hydrate iyi imabweretsa mapangidwe a netiweki ya gel yomwe imathandizira kuti yankho la yankho. Mphamvu imatengera kutentha, Ph, ndi kupezeka kwa mchere, koma ma molecular a hpmc amalola kuti apange netiweki yokhazikika pagawo.

Kulemera kwa maselo ndi polima
Kulemera kwa HPMC kumakhudza kwambiri ma visc. Kulemera kwapamwamba kwa ma polima amakhala ndi maunyolo atali ndi unyolo, zomwe zimakondana mosavuta, zikuwonjezera mawonekedwe a yankho. HPMC imapezeka m'makalasi osiyanasiyana ndi zolemera zosiyanasiyana, zimalola kuwongolera mafayilo a chinthu chatha. Kukopeka ndi kulumikizana kwa maunyolo awa amapanga netiweki komwe kumapereka uku.

Mafuta owombera:
HPMC imawonetsa katundu wapadera wa matenthedwe, pomwe imapanga gel otenthetsera ndikubwezeretsa yankho la kuziziritsa. Mitundu yosinthira iyi imachitika chifukwa cha magulu a methoxy ndi hydroxypyl, yomwe imathandizira hydrophobic mogwirizana ndi kutentha kwambiri, kumapangitsa kuti gel agwedezeke. Pakuziritsa, kusanthula kumeneku kuchepera, ndipo gel osungunula. Katunduyu ndi wothandiza kwambiri pantchito zofunika kutentha kumasintha ndikusunga zosasinthika.

Zachiwerewere:
Mayankho a HPMC amawonetsa machitidwe omwe sanali ku Newtonian, Sherning, akutanthauza kuti ma viscy awo amachepetsa ndikuwonjezeka. Katunduyu amawonetsetsa kuti mosiyanasiyana mosiyanasiyana, monga kusakaniza kapena kupopa njira zothetsera HPMC kumasinthiratu koma amabwerera ku boma lake loyambirira pomwe mphamvu yometa ubweya imachotsedwa. Khalidwe la thixotropic iyi limathandizira kusunthika mosalekeza mukamagwiritsa ntchito.

PH Kukhazikika:
Mosiyana ndi ma polima ena ambiri, hpmc ndi osakonda kusintha kwa pH kwa 3 mpaka 11. Kukhazikika kumeneku kumachitika chifukwa chokhudzana ndi ma acid kapena zitsulo. Zotsatira zake, HPMC imasunga ma vinyadi mosasinthasintha pamawu ambiri, kupangitsa kukhala koyenera kugwiritsa ntchito mafayilo osiyanasiyana momwe ph imasinthira.

Mapulogalamu opindulira opindulitsa
Mankhwala
M'mapangidwe a mankhwala opangira mankhwala, hpmc imagwiritsidwa ntchito ngati thicker, binder, ndi kumasulidwa - kumasulidwa-womasulidwa. Umboni wake wosasintha ndikofunikira kuti uwonetsetse magawidwe osokoneza bongo a yunifolomu, kuyimitsidwa kokhazikika, komanso mankhwala owonetsera bwino. Mwachitsanzo.

Makampani Ogulitsa Chakudya
M'makampani azakudya, HPMC imagwira ngati emulsifier, chisunthi, ndi kukula. Kutha kwake kupereka ufa wosasinthika ndikofunikira kuti musunge mawonekedwe ndi kukhazikika kwa zinthu ngati msuzi, mavalidwe, ndi mkaka. Mphamvu ya HPMC yamitundu ya HPMC imakhala yothandiza kwambiri pazinthu zomwe zimafunikira kusintha kwa mafalo pakuphika.

Kumanga
M'malo opangira, hpmc imagwiritsidwa ntchito mu simenti ndi mapulani a pulasitala kuti musinthe kugwirira ntchito, kusungidwa kwamadzi, komanso kutsatira. Umboni wosasintha mosalekeza umapangitsa kuti zinthuzi zizigwiritsidwa ntchito bwino ndikusungabe umphumphu pochiritsa.

Choongoletsera
HPMC imagwiritsidwa ntchito popanga zodzikongoletsera za kukula kwake ndikukhazikitsa malo. Zopangidwa monga zotupa, mafuta, ndi shampoos, ma viccy osasintha amathandizira mawonekedwe osangalatsa ndi kukhazikika, kukulitsa luso la ogwiritsa ntchito.

Zinthu zomwe zikukhudza mafakisoni komanso kuwongolera kwabwino
Pali zinthu zingapo zomwe zimatha kusintha mafayilo a HPMC njira, kuphatikizapo chidwi, kutentha, komanso kukhalapo kwa electrolyte kapena zina zowonjezera. Kuti mukwaniritse mawonekedwe osasinthika, ndikofunikira kuyang'anira magawo awa pakupanga ndi kukonza. Njira Zowongolera Zowongolera Zimaphatikizapo:

Kusankha kwazinthu:
Kuonetsetsa kugwiritsa ntchito cellulose kwambiri komanso kusamalira madigiri oyenera komanso molar m'malo ofunikira popanga hpmc ndi katundu wodalirika.

Njira Zopangira:
Njira Zogwirira Ntchito, kuphatikizapo kuwongolera kwenikweni kwa zochitika pakubwezeretsanso, ndizofunikira pakupanga HPMC yokhala ndi kulemera kosasunthika komanso magawo olowa m'malo mwake.

Kuyesa Kwachinthu:
Kuyesa kwa HPMIN Conces ya HPMC kuti ituluke, kugawa kolemetsa kwa maselo, komanso malo olowa m'malo amathandizira kusintha zinthu. Njira monga ma tcheenetry, gel permear mankhwala chratotographycopy.

Kusunga ndi Kusamalira:
Kusunga koyenera komanso kugwira ntchito kwa HPMC kuteteza chinyezi champhamvu komanso kuwonongeka. HPMC iyenera kusungidwa m'matumba a irtight komanso m'malo ozizira, owuma kuti asunge zinthu zake.

Kutha kwa HPMC kuperekera mafayilo osasinthasintha kuchokera ku mawonekedwe ake amtundu wake, mphamvu zamagetsi, ndi mpweya wambiri. Kukhazikika kwake kudutsa milingo yosiyanasiyana ya mankhunda, kuwonda miyala, komanso kugwiritsa ntchito modalirika mosiyanasiyana kumapangitsa polymer yofunika kwambiri m'mafakitale ambiri. Kudzera muyeso mosamala kwa njira zopangira ndi chitsimikiziro chabwino, opanga HPMC akuwonetsetsa kuti polymer polymer akupitiliza kukwaniritsa zofunikira zaomwe amafunikira.