1. Zoyambira za HPMC
HyPromellose, Chingerezi dzina la hydroxpyl methylcellulose, Alias HPMC. Njira yake ya molecular ndi C8H15o8- (C10hl8o6) N-C8hl5o8, ndipo kulemera kwake ndi gawo la 86000. Izi ndi gawo la ma polyhydropyl etheluluse. Itha kupangidwa ndi njira ziwiri: chimodzi ndikuti kalasi yoyenera ya methyl cellulose imathandizidwa ndi Naoh, kenako ndikuchita ndi Promple oxide pansi pa kutentha ndi kukakamizidwa. Fomuyi imalumikizidwa ndi mphete ya anilroglucose ya cellulose, ndipo imatha kufikira mulingo wabwino; Wina ndi kuchitira thonje kapena chotchinga chotchinga cha nkhuni ndi custic chloride ndi ma prowyne oxide okwana, kenako ndikuphwanya ufa kapena ma granules. HPMC ndi mitundu yosiyanasiyana ya cellulose, ndipo imakhalanso ndi mankhwala abwino kwambiri, omwe ali ndi magwero osiyanasiyana. Pakadali pano, imagwiritsidwa ntchito padziko lonse lapansi ndi kunja, ndipo ndi imodzi mwazomwe zimathandizira kuchuluka kwa mankhwala ogwiritsa ntchito pakamwa.
Izi ndizoyera kuti mkaka ukhale woyera, wosakhala wopanda zokongoletsera komanso wopanda pake, ndipo ali ndi ufa wa glanular kapena ufa woyenda mosavuta. Imakhazikika moyang'aniridwa ndi kuwonetsedwa ndi chinyezi. Amatupa m'madzi ozizira kuti apange yankho la ma colloidal oyera, omwe ali ndi mawonekedwe ena a sol-gel ozungulira amatha kuchitika chifukwa cha kutentha kwa njira inayake. Imasungunuka kwambiri mu 70% mowa kapena kemthyl ketone, ndipo osasungunuka mumvula, chloroform kapena ethoxythane.
Pamene PH of HyPromelse ili pakati pa 4.0 ndi 8.0, ili ndi bata wabwino, ndipo zimatha kukhalapo pang'ono pomwe PH ili pakati pa 3.0 ndi 11.0. Matenthedwe ndi 20 ° C ndi wachibale chinyezi ndi 80%, amasungidwa kwa masiku 10. Kuyamwa kwachinyezi kwa hpmc ndi 6.2%.
Chifukwa cha zomwe zili mkati mwa memoxy ndi hydroxypypyl popanga hypomellose, mitundu yosiyanasiyana ya zinthu zosiyanasiyana zawonekera. M'malingaliro ena, mitundu yosiyanasiyana ya malonda imakhala ndi mafakitale ena komanso kutentha kwamiyala, chifukwa chake, imakhala ndi zinthu zosiyanasiyana ndipo zitha kugwiritsidwa ntchito pazifukwa zosiyanasiyana. The pharmacopoeias wa maiko osiyanasiyana ali ndi malamulo osiyanasiyana ndi mawonekedwe osiyanasiyana pa mitundu: Malinga ndi maginito osiyanasiyana omwe amagulitsidwa pamsika, ndikuyimiriridwa ndi manambala kuphatikiza manambala, ndipo unit ndi a MPPID; Ku United States Memini ya United States, dzina lodziwika limawonjezera manambala 4 kumapeto kwake kuti awonetsetse zomwe zili ndi mitundu iwiri ya Ithoxy, ndipo manambala awiri omaliza akuimira ma hydroxypyl kuchuluka kwa.
2. Njira yosungunuka hpmc m'madzi
Njira Yamadzi Yamadzi
Popeza HyPromellose sasungunuka m'madzi otentha, imatha kukhala yobalalika m'madzi otentha pachiyambi, kenako nkuzizira. Njira ziwiri zomwe zafotokozedwa motere:
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2.2 Njira Yosakaniza
Tinthu tating'onoting'ono timabalalika kwathunthu posakaniza ndi mitundu yofanana kapena yochulukirapo ya zosakaniza zina za ufa, kenako kusungunuka m'madzi. Pakadali pano, hypereyose amatha kusungunuka popanda kuchitika.
3. Ubwino wa HPMC
3.1 madzi ozizira
Sungunulani m'madzi ozizira pansi pa 40 ° C kapena 70% ethanol, osasunthika m'madzi otentha kuposa 60 ° C, koma atha kukhala ndi chidwi.
3.2 Kugwiritsa Ntchito Mankhwala
HyPromellose (HPMC) ndi mtundu wa ether ether ether. Njira yake ilibe nyumba ya Ionic ndipo samalankhula ndi mchere wachitsulo kapena ionic okonda. Chifukwa chake, ena osapeza sachita nawo panthawi yokonzekera.
3.3 Kukhazikika
Imakhazikika kwa asidi ndi alkali, ndipo imatha kusungidwa kwa nthawi yayitali pakati pa PH 3 ndi 1L popanda kusintha kodziwikiratu. Madzi am'madzi a hyPromellose (hpmc) ali ndi anti-gembewf protem ndipo amatha kukhalabe okhazikika pakusungidwa kwakanthawi. Mankhwala ogwiritsa ntchito ma hpmc monga omwe amakupatsani bwino amakhala ndi bata wabwino kuposa omwe amagwiritsa ntchito zikhalidwe (monga dextrin, wowuma, etc.).
3.4 Kusintha kwa Mavicec
Maonekedwe osiyanasiyana a hpmc amatha kusakanikirana malinga ndi ma ratios osiyanasiyana, ndipo mavitu ake amatha kusintha malinga ndi malamulo ena, ndipo ali ndi ubale wabwino, kotero kuchuluka kwake kungasankhidwe molingana ndi zofunikira.
3.5 Metabolic Bartia
HPMC siimatengeka kapena yopangidwa mthupi, ndipo sapereka kutentha, kotero kukonzekera kwa mankhwala opezeka m'matumbo.
3.6 Chitetezo
Nthawi zambiri amakhulupirira kuti HPMC ndi zinthu zosafunikira komanso zosasangalatsa. Mlingo wa mbewa zam'madzi ndi 5g / kg, ndi mlingo wa makoswe a makoswe ndi 5.2g / kg. Mlingo watsiku ndi tsiku ndi wopanda vuto kwa anthu.
4. Kugwiritsa ntchito hpmc pokonzekera
4.1 Monga kanema wokutira ndi zinthu zopanga mafilimu
Kugwiritsa ntchito HyPromellose (HPMC) ngati mapiritsi okhala ndi mafilimu ophimbidwa, poyerekeza ndi mapiritsi okhala ndi zikhalidwe monga mapiritsi okhala ndi shuga, matebulo okhala ndi mapiritsi, osakhazikika, zowonjezera kulemera kwake ndi zina zabwinobwino. Kalasi yotsika kwambiri ya mankhwalawa imagwiritsidwa ntchito ngati mawonekedwe osungunuka filimu yamadzi ndi mapiritsi, ndipo kalasi yapamwamba kwambiri imagwiritsidwa ntchito ngati mawonekedwe okutira mafilimu a mapangidwe osinthika. Kuchulukana nthawi zambiri kumakhala 2.0% mpaka 20%.
4.2 Monga womangika ndi kuwonongeka
Kalasi yotsika kwambiri ya mankhwalawa itha kugwiritsidwa ntchito ngati binder ndi kuwonongeka kwa mapiritsi, mapiritsi, ndi maganya, komanso kalasi yapamwamba kwambiri imangogwiritsidwa ntchito ngati binder. Mlingo umasiyanasiyana ndi mitundu yosiyanasiyana ndi zofunikira. Nthawi zambiri, mlingo wa mapiritsi owuma ma glanuration ndi 5%, ndipo mlingo wa binder ya mapiritsi onyowa granution ndi 2%.
4.3 Monga Wogulitsa
Wogwira ntchitoyo ndi zinthu zowoneka bwino ndi hydrophilicity, zomwe zimatha kuchepetsa liwiro la tinthu tating'onoting'ono titagwiritsidwa ntchito poyimilira, ndipo imatha kuphatikizidwa pamwamba pa tinthu toyambitsa tinthu toyambitsa tinthu tambiri. Kusuma kwa malo ofunikira popanga kuyimitsidwa. HPMC ndi mitundu yosiyanasiyana yopumira, ndipo mawonekedwe ake a Collolleal amatha kuchepetsa utoto wamadzimadzi ndi mphamvu yaulere pamatumba ang'onoang'ono olimba, potero amalimbikitsa kukhazikika kwa dongosolo la herurogeneous. Kalasi yowoneka bwino ya mankhwalawa imagwiritsidwa ntchito ngati kuyimitsidwa - kukonzekera kwamadzi kukonzekera ngati kuyimilira. Ili ndi vuto lalikulu, ndizosavuta kubwezeretsanso kubwezeretsanso, silimamatira kukhoma, ndipo lili ndi tinthu tabwino. Mlingo wachizolowezi ndi 0,5% mpaka 1.5%.
4.4 Monga blocker, wosuta-wosuta ndi wosuta
Kalasi yapamwamba kwambiri ya mankhwalawa imagwiritsidwa ntchito kukonza mapiritsi a hydrophilic gel. Kugwiritsa ntchito mwamphamvu kwa 10% ~ 80% (W / W). Makina otsika otsika amagwiritsidwa ntchito ngati othandizira opanga poores kuti atulutsidwe kapena kumasulidwa-kutulutsidwa. Mlingo woyamba wofunikira pakuchiritsa kwa piritsi yamtunduwu kungatheke mwachangu, kenako ndikumasulidwa kapena kumasulidwa, kumasulidwa, ndikumasulidwa magazi, ndipo mankhwala osokoneza bongo amasungidwa mthupi. Pamene hypromellose imakumana ndi madzi, imakhala ndi ma hydrate kuti apange gel wosanjikiza. Limagwirira mankhwala osokoneza bongo ku matrix makamaka amaphatikizanso mawonekedwe a gel wosanjikiza wa gel wosanjikiza.
4.5 COUNTO yoteteza ngati thickener ndi colloid
Izi zikagwiritsidwa ntchito ngati thicker, zomwe zimagwiritsidwa ntchito kawirikawiri kwambiri ndi 0,45% ~ 1.0%. Izi zitha kuwonjezera kukhazikika kwa guluu hydrophobic, ndikupanga collouid yoteteza, kupewa, potero imalepheretsa mapangidwe a stortments, ndipo chidwi chake chovuta ndi 0,5%.
4.6 Zida za kapisozi za makapisozi
Nthawi zambiri kapisozi kapisozi kapisozi kapisozi kamakhazikitsidwa pa gelatin. Kupanga kwa zipolopolo za gelatin kapisozi ndikosavuta, koma pali zovuta zina komanso zowopsa ngati mankhwala osokoneza bongo otetezedwa ndi chinyezi, ndikuchepa kusokonekera kwa kapisozi panthawi yosungirako. Chifukwa chake, hypomelfelose, monga choloweza mmalo mwa gelatin makapisozi, amagwiritsidwa ntchito pokonza makapisozi, zomwe zimapangitsa kuti camossulity ikhale yolinganiza mapiritsi ndi kudziko lina.
4.7 Monga biohedesive
Technology ya biohethesion, kugwiritsa ntchito zokongoletsera ndi ma polima a biohedes, kudzera muchokani kwa chitsamba chazomwe zimachitika pang'onopang'ono komanso zotheka kuti mankhwalawa atulutsidwe pang'onopang'ono ndikuyamba kukwaniritsa zolinga. Pakadali pano zimagwiritsidwa ntchito pochiza matenda a m'mphuno, mucosa mkamwa ndi mbali zina. Technology yama biohedeya ion ndi njira yatsopano yoperekera mankhwala yomwe idayamba posachedwa. Sikuti amangotaya nthawi yokhala yokonzekera mankhwala opangira m'mimba, komanso amathandizanso kulumikizana pakati pa masentimita a cell, potero kukonza biothelilability wa mankhwala.
4.8 Monga gel osakaniza
Monga kukonzekera kosangalatsa kwa khungu, gel ali ndi zabwino monga chitetezo, kukongola, kuyeretsa kosavuta, mtengo wotsika mtengo, njira yabwino yokonzekera mankhwala. malangizo.
Post Nthawi: Feb-14-2025