Nkhani

Hydroxypypyl methylcellulose. Ndi zinthu zabwino zopangira mafilimu osungunuka madzi.

Kanema wosungunuka wamadzi ndi mtundu watsopano wa zomwe Green Packigating zinthu, zomwe zalandira chisamaliro chochulukirapo ku Europe ndi United States ndi mayiko ena. Sizabwino komanso zosavuta kugwiritsa ntchito, komanso zimathetsa vuto la kutaya zinyalala. Pakadali pano, mafilimu osungunuka amadzi amagwiritsa ntchito zida zochokera ku petrolelem monga mowa wa polyvinyl ndi polyethylene oxide ngati zida zopangira. Petroleum ndi gwero losasinthika, ndipo kugwiritsa ntchito kwakukulu kumabweretsa kuchepa kwa zinthu. Palinso mafilimu osungunuka osungunuka omwe amagwiritsa ntchito zinthu zachilengedwe monga wowuma ndi mapuloteni ngati zida zophika, koma mafilimu osungunuka awa ali ndi katundu wosachita makina. Mu pepala ili, kanema watsopano wa filimu yosungunuka yamadzi idakonzedwa ndi njira yolumikizira njira yopanga filimu pogwiritsa ntchito hydroxypropyl wa methylcelulose. Zotsatira za kuchuluka kwa HPMC View-form Mafuta ndi kutentha kwa filimu pamphamvu ya anthu owoneka, yopuma, yopepuka ndi madzi osungunuka ndi mafilimu osungunuka. Glycerol, sorbitol ndi glutaraldehyde adagwiritsidwa ntchito kukonzanso magwiridwe antchito a HPMC. Pomaliza, kuti muwonjezere kugwiritsa ntchito kanema wa HPMC-kusungunuka kwamadzi mu kanikidwe ka chakudya, tsamba la nsungwi la antioxidant (AOB) lidagwiritsidwa ntchito kukonza ma antioxidantant makanema a HPMC. Zopeza zazikulu ndi izi:

. Pamene HPMC ndende ili 5% ndipo filimu yopanga filimuyi ndi 50 ° C, zinthu zokwanira za filimu ya HPMC ili bwino. Pakadali pano, kulimba kwamphamvu kuli pafupifupi 116mmka, mtunda wa nthawi yopuma ndi 31%, nthawi yopepuka ndi 90%, ndipo nthawi yosungunuka ndi 55min.

. Pamene zomwe zili mu glycerol zili pakati pa 0,05% ndi 0,25%, zotsatira zake ndizabwino kwambiri, ndipo mtunda wosungunuka wa HPMC Madzi osungunuka amafika pa 50%; Pamene zomwe zili ku Sorbitol ndi 0.15%, mtunda wanthawi yopumira umawonjezeka mpaka 45% kapena apo. Kanema wa HPMC atasungunuka madzi atasinthidwa ndi glycerol ndi sorbitol, mphamvu yakuwoneka komanso koloko yowala idachepa, koma kuchepa sikunali kofunikira.

. Kuphatikiza kwa glutaraldehyde kunali 0,25%, makinawo, makina ndi owoneka owoneka bwino a mafilimu adafika pamalo abwino. Kuphatikiza kwa glutaraldehyde kunali 0,44%, nthawi yosungunuka madzi idafika 135 min.

. Pamene 0.03% AOB adawonjezeredwa, filimu ya AOB / HPMC idapanga pafupifupi 89% ya DPHH yaulere ya DPMH yakhala yabwino kwambiri, yomwe inali yayikulu kuposa iyo ya HPMC idasinthidwa kwambiri.

Mawu ofunikira: filimu yosungunuka yamadzi; hydroxypypyl methylcelulose. pulasitiki; wothandizira wolumikizira; Antioxidant.

M'ndandanda wazopezekamo

Chidule ................................................ ............................................................................................................... .i

Osagwirizana ...................

M'ndandanda wazopezekamo…………………………………………. ....................................................... ...

MUTU Woyamba ................................................ ........................................................................... .1

1.1ater-solubleby ficnifi filimu .....................

1.1.1Palyvinyl mowa (PRA) filimu yamadzi-soduble .......................................................

1.1.2Polyelylene oxide (peo) filimu yamadzi yosungunuka .................

1.1.3stle-souble filimu yamadzi .............

1.1.4 Mafilimu osungunuka-osungunuka - osungunuka .................................................................

1.2 hydroxypropyl methylcellulose ...............................................................................

1.2.1 Kapangidwe ka Hydroxpyl No Methylcellulose ............................................

1.2.2 Kusungunuka kwamadzi kwa hydroxypypyl methylcellulose .............

1.2.3 Kupanga mafilimu a Hydroxypylth Methylcellulose ............................................

1.3 Kusintha kwa Mapulasitiki ya Mapulogalamu a Hydroxypypyl filimu filimu ............................... ..4

1.4 Kusinthana kwa ma hydroxypypyl methylcellulose filimu ............................

1.5 antioxida dialsties a hydroxypypyl methylcellulose filimu ................. 5

1.6 lingaliro la mutuwo ............................................. .............................................. .7

1.7 Zofufuzira ................................................................................................... ..

Chaputala 2 Kukonzekera ndi Katundu wa Hydroxypropyl Test Cellulose Makina filimu yam'madzi ...............

2.1 Kuyamba ................................................................................................... 8

2.2 Chigawo choyesera ......................................................... .................................................. .8

2.2.1 Zipangizo ndi zida ............................................... ......... ..8

2.2.2 Specimen Preparation ………………………………………… ………………………………………………………..9

2.2.3 Kuyesedwa ndi Kuyeserera kwa Ntchito .............................................................

Makina a 2.2.4 ................................................ ............................................................................ 10

2.3 Zotsatira ndi Zokambirana .............

2.3.1 Mphamvu ya njira yothetsera filimu ya HPMC yoonda .......................................................................................................... 10

2.3.2 Kuteteza filimu yopanga filimu pa mafilimu oonda a HPMC ...............

Chidule cha mutu 2.4 .............

MUTU 3 Zotsatira za Mafupa za Mafupa za HPMC

3.1 Kuyamba ...................................................................................................................................

3.2 Gawo Loyesera .............

3.2.1 Zipangizo zoyesera ndi zida .......................................................................

3.2.2 Kukonzekera kwa Chovala ................................................................................

3.2.3 Kuyesedwa ndi Kuyeserera kwa Magwiridwe Ntchito .............

3.2.4 Kukonzanso deta ................... ................................................. ..19

3.3 Zotsatira ndi Zokambirana .......................................................................................

35.1

3.3.2 Mphamvu ya Glycerol ndi Sorbitol pa mafilimu owonda a HPMC OGONC .....................................................................................

3.3.3

3.3. Zotsatira za glycerol ndi sorbitol pazomwe zimapangitsa kuti HPMC FIMMS ...............................

3.3.5 Mphamvu ya Glycerol ndi Sorbitol pamadzi osungunuka a HPMC .......... 23

3.4 Chaputala Chidule ...

Chaputala 4 zotsatira za othandizira pa HPMC Masamba osungunuka Madzi .....................

4.1 Kuyamba Kuyamba ....................................... 25

4.2 Gawo Loyesera .......................................................................................................

4.2.1 Zipangizo zoyesera ndi zida .......................................................

4,2.2 Kukonzekera kwa Chovala ....................................................................................................

4.2.3 Makhalidwe ndi Kuyeserera kwa Ntchito .............

4,2.4 Kukonzanso deta ....................................................... ................................................... .26

4.3 Zotsatira ndi Zokambirana .....................................................................................................

4,3.1 infrated spoprum ya glutaraldelwerdehyde-mtanda owonda .......................

4,3.2 Xrd ya mafilimu ophatikizika a HPMC owonda ........................... ..27

4.3.3 Mphamvu ya glutaraldehyde pamadzi osungunuka a HPMC ......................

4.3.

4,3.5 zotsatira za glutaraldehyde pazinthu zowoneka bwino za HPMC .......................

4.4 Mutu wachidule ...............................................................

MUTU 5 Wachilengedwe wa Antioxidant HPMC Madzi osungunuka Madzi .............

5.1 Kuyamba .........................................................................................................................

5.2 Gawo loyesera .........................................................................................................

5.2.1 Zida zoyesera ndi zida zoyesera ...............................................................

5.2.2 Kukonzekera kwa Chovala .......................................................................................................... .32

5.2.3 Kuyesedwa ndi Kuyeserera kwa Ntchito ...................................................................................................

5.2.4 Kukonzanso deta .............................................................................................................................................................................................................. .........................................................................

5.3 Zotsatira ndi Kusanthula ...............

5.3.1 Ft-IR-IR .................................................................................................

5.3.2 Kuwunika Kwa Xrd ...............

5.3.3 Antioxidant katundu ...........................................................................................................................

5.3.4 Kusungunuka kwamadzi ................................................................................................................................

5.3.5 makina ochitira .....

5.3.6 Mankhwala owoneka bwino .......................................................................................................................

5.4 Chaputala Chidule ..........................................................................................

MUTU 6 DuANI ....................................................... ................................................. ..39

mafotokozedwe .............................................................................................................................................................

Zofufuzira Zakafukufuku Nthawi Zambiri ..........................................................................

Zikomo ..........................................................................................................................

MUTU UMODZI

Monga momwe bukuli limasinthira zinthu, kanema wosungunuka wamadzi wagwiritsidwa ntchito kwambiri pakupanga zinthu zosiyanasiyana m'maiko akunja (monga United States, Japan, France, France, France,. Filimu yosungunuka yamadzi, monga momwe dzina limatanthawuza, ndi kanema wapulasitiki yomwe imatha kusungunuka m'madzi. Amapangidwa ndi zida zosungunulira madzi osungunuka zomwe zimatha kusungunuka m'madzi ndipo imakonzedwa ndi njira inayake yopanga filimu. Chifukwa cha katundu wake wapadera, ndioyenera anthu kuti azinyamula. Chifukwa chake, ofufuza ochulukirachulukira ayamba kusamala ndi zofuna za kutetezedwa ndi chilengedwe komanso zosavuta [2].

1.1 filimu yosungunuka yamadzi

Pakadali pano

1.1.1 Molyvinyl Mowa (PRA) filimu yamadzi yosungunuka

Pakadali pano, mafilimu osungunuka kwambiri padziko lonse lapansi amakhala mafilimu osungunuka. PRA ndi polymer ya vinyl yomwe itha kugwiritsidwa ntchito ndi mabakiteriya ngati gwero la kaboni ndi gwero lazinthu zamitundu yotsika, kukana mafuta ndi mpweya wotchinga (4]. Filimu ya PLA ili ndi mphamvu yabwino, kusinthasintha kwamphamvu komanso kutetezedwa kwabwino zachilengedwe. Zagwiritsidwa ntchito kwambiri ndipo imakhala ndi malonda ogulitsa. Ndi pafupi kwambiri ndi filimu yayikulu kwambiri yosungunuka kwambiri pamsika [5]. Pva ali ndi vuto labwino ndipo amatha kuwola ndi tizilombo tating'onoting'ono tomwe timapanga CE2 ndi H2O m'nthaka [6]. Kufufuza kwa makanema osungunuka osungunuka madzi tsopano ndikusintha ndikuphatikiza iwo kuti apeze mafilimu abwino osungunuka. Zhao Linlin, Xioiong Hanguo [7] adaphunzira kukonza kanema wosungunuka wamadzi ndi pva, st) 20%, gelatin dodecyl sulfate (sds) 4%. Pambuyo ma microwave kuwuma filimu yomwe idapezeka, nthawi yosungunuka yamadzi m'madzi kutentha kutentha ndi kwa 101s.

Poona zochitika zaposachedwa, filimu ya PLA imagwiritsidwa ntchito kwambiri, mtengo wotsika, komanso wabwino m'malo osiyanasiyana. Ndiwo malo osungunuka bwino kwambiri pamadzi omwe alipo. Komabe, monga zinthu zochokera ku petroleum, PRA ndichinthu chosakhazikika, ndipo njira zake zopangira zitha kuipitsidwa. Ngakhale United States, Japan ndi mayiko ena alembapo kanthu monga poizoni, chitetezo chake chikadaliponso. Ma inhalation inhalation ndi kulowetsedwa ndizovulaza thupi [8], ndipo silingatchedwa chemistry yathunthu yobiriwira.

1.1.2 Polyethylene oxide (peo) filimu yamadzi

Polyethyle Texide, amadziwikanso kuti polyethylene oxide, ndi polyrmocciastic, polymer osungunuka omwe amatha kuphatikizidwa ndi madzi mu gawo lililonse kutentha kwa chipinda [9]. Njira yodziwika ya polyethylene oxide ndi H - (- OCH2ch2- )- Kulemera kwa maselo ali mu 200 ~ 20000, kumatchedwa poltolothylene glycol (msomali), ndipo kulemera kwa matope ndi oposa 20,000 amatha kutchedwa polythylene oxide (10]. Peo ndi ufa woyera ufa wa glander, womwe ndi wosavuta kuwongolera ndi mawonekedwe. Mafilimu a peo nthawi zambiri amakonzedwa ndikuwonjezera mapulasitiki, okhazikika ndi mafilimu a peo resun procep [11].

Pika filimuyi ndi filimu yosungunuka ndi madzi okhala ndi madzi abwino okhalapo, ndipo mphamvu zake zimakhalanso zabwino, koma ma peo ali ndi zovuta, komanso njira zambiri zomwe zimapangitsa kuti chilengedwe chikhalepo. PRA filimu ina. Kuphatikiza apo, peo ilinso ndi zoopsa zina, motero sizimagwiritsidwa ntchito kawirikawiri m'malo ogulitsira.

1.1.3 filimu yopukutira-soubu yosungunuka

Wopukutira ndi polecular yayikulu yachilengedwe, ndipo mamolekyulu ake ali ndi magulu ambiri ma hydroxyl, kotero pali kulumikizana kwamphamvu pakati pa mamolekyulu owuma, kotero pali kulumikizana kwa mamolekyulu ndi njira yosauka, ndipo ndikovuta kulumikizana ndi ma poizoni ena. anakonzedwa limodzi [14,15]. Madzi osungunuka a wowuma ndi osauka, ndipo zimatenga nthawi yayitali kumadzi ozizira, kotero kuti, wowuma sungunuka madzi, nthawi zambiri amagwiritsidwa ntchito pokonza mafilimu osungunuka. Nthawi zambiri, wowuma amasinthidwa mwanjira mwanjira monga kufufuzidwa, kumangiriza, ndikulumikiza kuti asinthe madzi owoneka bwino.

Yambitsani kulumikizana kwa ether kukhala magulu opindika pogwiritsa ntchito mankhwala kapena kugwiritsa ntchito oxidal owuma kuti awononge mtundu wambiri wosinthidwa popanda magwiridwe antchito abwino. Komabe, kutentha kochepa, filimu yopuula imakhala ndi ndalama zambiri komanso kuwonekera bwino, motero nthawi zambiri, pamafunika kukhala okonzekera kuphatikizidwa ndi zinthu zina monga za Pva, ndipo mtengo weniweni sukwera.

1.1.4 Ma protein-osungunuka owopsa

Mapuloteni ndi njira yachilengedwe ya macaromalecular yomwe ili mu nyama ndi zomera. Popeza mapuloteni ambiri mapuloteni amakhutira m'madzi kutentha kwa firiji, ndikofunikira kuthetsa kusungunuka kwa mapuloteni m'madzi mu firiji kuti akwere mafilimu osungunuka ndi zida. Pofuna kukonza kusungunuka kwa mapuloteni, ayenera kusinthidwa. Njira zosinthika zamankhwala zimaphatikizapo deffalemination, phtaloamations, phosphorylation, etc. [18]; Kusintha kwa kusinthaku ndikusintha mawonekedwe a mapuloteni, potero akuwonjezera kulonjera, minyewa, ntchito monga mankhwalawa amakwaniritsa zosowa zopanga ndi kukonza. Makanema osungunuka osungunuka ndi ma protein amatha kupangidwa pogwiritsa ntchito zida zaulimi monga zida monga zida zomera, kapena pofuna kupanga mabizinesi a sewe, ndipo zida sizingakhudze chilengedwe [19]. Komabe, mafilimu osungunuka amakonzedwa ndi mapuloteni omwewo monga matrix ali ndi katundu wosakhazikika ndi kusungunuka kwamadzi otsika kutentha kapena kutentha kwawo ndi kopakutira.

Kuwerenga, ndikofunikira kwambiri kukulitsa mawonekedwe atsopano a filimu yatsopano yomwe mukufuna kukonza zofooka za mafilimu osungunuka.

Hydroxypropyl mealyuluse (hydroxypropyl methy cellouse, hpmc kuti muchepetse zinthu zachilengedwe, komanso zopanda pake, osapikisana ndi anthu zakudya, komanso zochulukirapo]. Ili ndi madzi abwino osungunuka ndi mawonekedwe a makanema, ndipo ali ndi zofunikira kukonza mafilimu osungunuka.

1.2 hydroxypropyll methylcelulose

Hydroxypropyl me cellulose (hydroxypropyl methyl celyose, hpmc kuti muchepetse mankhwalawa, omwe amakwaniritsidwa ndi kusintha njira. Pa celluloby yosungunulira madzi. Hydroxypypyl methylcellulose ili ndi izi:

(1) zochulukirapo komanso zokonzanso. Zopangira za hydroxpyl methylcellulose ndiye cellulose yochuluka kwambiri padziko lapansi, yomwe ndi ya zinthu zachilengedwe zokonzanso.

(2) Zachilengedwe komanso za biodegrable. Hydroxypropyll methylcellulose sikuti ndi poizoni komanso yovulaza kwa thupi la munthu ndipo imatha kugwiritsidwa ntchito mu mankhwala ndi mafakitale.

(3) osiyanasiyana amagwiritsidwa ntchito. Monga zosungunuka zamadzi zosungunuka, hydroxypropyl methylcellulose ali ndi madzi abwino kususuka, kubala, ndi zina zamagetsi ndi zamagetsi ndi zamagetsi.

1.2.1 Kapangidwe ka Hydroxypypyll Methylcelulose

HPMC imapezeka kuchokera ku cellulose yachilengedwe mutatha kuyamwa, ndi gawo lake la polyhydropyl ndi methyl amakhazikika ndi ma propyl oxide ndi methyl chloride. Wogulitsa wamkulu wa HPMC Methyl amachokera ku 1.0 mpaka 2.0, ndi hydroxypropyl digiri yochokera ku 0.1 mpaka 1.0. Njira yake ya molecular imawonetsedwa Chithunzi 1.1 [22]

Chifukwa cha haidrojeni wamphamvu pakati pa cellulose ya macromolecles, ndikovuta kusungunuka m'madzi. Kusungunuka kwa celluul collelulose m'madzi kumakhala bwino kwambiri chifukwa magulu a Ether adayambitsidwa ndi ma cellulose osinthika, omwe amawononga mamona a hydrogen pakati pa ma te celluse ndikuwonjezera kusungunuka kwake m'madzi [23]. Hydroxypylfelllulose (hpmc) ndi ma hydroxyalkyl alkyl osakanikirana (-Och2) Zosakaniza eded ndikuwunika kwathunthu kwa mgwirizano ndi chopereka cha gulu lirilonse. - [OCH2CH (Ch3)] Nyimbo ya hydroxyl kumapeto kwa a n o gulu la Ah ndi gulu logwira ntchito, lomwe lingafanane ndi ma hydroxyantermy, omwe ali ndi mphamvu yamtundu wina, yomwe ili ndi miyala yamtundu wina wamkati pa ma macromolecular unyolo; -Och3 ndi gulu lothamanga, malo omwe achitika pambuyo polowa m'malo mwake, ndipo ndi gulu lalifupi la hydrophobic lalifupi [Chithunzi patsamba 21]. Magulu a Hydroxyl pa nthambi yatsopano ndi magulu a hydroxyl otsalira pa magulu a glucose amatha kusinthidwa ndi magulu omwe ali pamwambawa, zomwe zimapangitsa zinthu zovuta kwambiri.

1.2.2 Madzi osungunuka a hydroxypropyll methylcellulose

Hydroxypropyl methylcellulose ali ndi zinthu zambiri zabwino zambiri chifukwa cha kapangidwe kake, zomwe zingachitike kwambiri ndi madzi ake. Imatupa mu njira ya colloidal m'madzi ozizira, ndipo yankho limakhala ndi zochitika zina zapadziko lonse, kuwonekera kwambiri komanso kusunthika. Hydroxypypyl nothClulose ndi ethel ethelose yopezeka pambuyo pa methylclulose yosinthidwa ndi ma protheration ozizira komanso madzi otentha a methylcelulose. Methyl cellulose imayenera kuyikidwa pa 0 mpaka 5 ° C kwa mphindi 20 mpaka 40 kuti mupeze njira yabwino yothandizira komanso yokhazikika [25]. Njira yothetsera hydroxypropyl mankhwala okhaokha amangofunika kukhala 20-25 ° C kuti mukwaniritse bwino komanso kuwonekeranso bwino [25]. Mwachitsanzo, hydroxypypyupyl methylcellulose (mawonekedwe a granolar from 0.2-0.5 mm)

1.2.3 Kupanga mafilimu a hydroxypypyl methylcellulose

Hydroxypylropyl Sothyllulose yankho lili ndi katundu wabwino kwambiri wamakanema, omwe amatha kupereka malo abwino opangira mankhwala opangira mankhwala. Makanema ophatikizidwa ndi iwo ndi opanda utoto, opanda fungo, olimba komanso owoneka bwino [patsamba 21].

Yan Yanzi [26] anagwiritsa ntchito mayeso a Orthogonal kuti afufuze zomwe makanema amapangira hydroxpyl wa methylcellulose. Kuwunika kunachitika m'magawo atatu okhala ndi zozungulira zosiyanasiyana komanso ma sol sols. Zotsatira zake zidawonetsa kuti kuwonjezera 10% hydroxypypyulose mu 50% ethanol inali ndi katundu wabwino kwambiri wamafilimu, ndipo zitha kugwiritsidwa ntchito ngati chinthu chopangira mafilimu omasulidwa.

1.1 Kusintha kwa mapulasitiki ya mafilimu a hydroxypypyl methylcellulose filimu

Monga momwe zinthu zachilengedwezo zimapangidwira, makanemawo adakonzekeretsa cellulose monga cholembera chimakhala ndi bata komanso kusakhazikika, ndipo ndi biodeggradodid atatayidwa, zomwe sizovulaza chilengedwe. Komabe, mafilimu osagwiritsidwa ntchito pa celluse osakhazikika ali ndi mphamvu yosavuta, ndipo cellulose imatha kukhala yopikika komanso yosinthidwa.

[27] Zotsatira zake zinawonetsa kuti mmodzi mwa ma celluuse aceulipate filimuyo idawonjezeredwa ndi 50% ndi 50% pomwe chidutswa cha triethl cingratyl anali 10%.

Luo qiuwai et al [patsamba 28] adaphunzira za Al [28] Al [28] al al. Zotsatira zake zinawonetsa kuti kuchuluka kwa methyl cellulose kunali bwino pamene glycerol yokhala ndi 1.5%, ndi chiwerengero chachikulu cha methyl celluse ndi ma acid 0,5%.

Glycerol ndi mtundu wopanda mtundu, wokoma, wowoneka bwino, wamafuta owoneka bwino, omwe amadziwika kuti glycerin. Oyenera kusanthula mayankho am'madzi, onunkhira, ma pulasitiki, etc. Itha kusungunuka ndi madzi muyezo uliwonse, ndipo magetsi otsika kwambiri amatha kugwiritsidwa ntchito ngati mafuta owuma kuti anyowetse khungu. Sorbirol, yoyera ya hygroscopic ufa kapena ufa wa crystalline, flakes kapena granules, zopanda fungo. Ili ndi ntchito za chinyezi komanso kusungidwa kwamadzi. Kuphatikiza pang'ono pakupanga chingamu ndi maswiti amatha kusunga chakudyacho, kukonza gulu ndikuchepetsa kuuma ndi kusewera mchenga. Glycerol ndi sorbitol ndi zinthu zonse zosungunulira madzi, zomwe zitha kusakanizidwa ndi cellulose yosungunuka yamadzi et [23]. Amatha kugwiritsidwa ntchito ngati magupusi a cellulose. Pambuyo powonjezera, amatha kusintha kusinthasintha komanso kukhala ndi mafilimu ophwanyika mafilimu a cellulose. [29]. Nthawi zambiri, kuchuluka kwa yankho ndi 2-5%, ndipo kuchuluka kwa pulasitiki ndi 10-20% ya ethel ether. Ngati zomwe zili mupulati ya pulasitiki ndizokwera kwambiri, shrinage sohyonen ya ma dehloid kudzikuza kwambiri zidzachitika kutentha kwambiri [30].

1.2 kusinthanitsa kwa hydroxypypyl fitylcelulose filimu

Filimu yosungunuka imakhala ndi madzi abwino kusungunuka, koma sikuyembekezeka kupasuka msanga mukamagwiritsa ntchito kangapo, monga matumba adzuwa. Mbewuzo zimakutidwa ndi filimu yosungunuka yamadzi, yomwe imatha kuwonjezera kuchuluka kwa njere. Pakadali pano, pofuna kuteteza nthanga, sizikuyembekezeredwa kuti filimuyo idzasungunuka mwachangu, koma filimuyo iyenera kukasewera madzi ena osungirako madzi. Chifukwa chake, ndikofunikira kupitirira nthawi yosungunuka ya filimuyo. [Chithunzi patsamba 21].

Chifukwa chomwe Hydroxpyl Methylcellulose ali ndi madzi abwino osungunuka ndi ma hydroxyll Methylcellulose imachepetsedwa, potengera madzi osungunuka a hydroxypyulose filimu filimu, ndipo njira yolumikizirana pakati pa ma hydroxyl imapangitsa makina ambiri a mafilimu, omwe amathanso kusintha makina a filimuyo pamlingo wina. A Aldehyds olumikizidwa ndi hydroxypropyll imaphatikizapo glutararyehyde, glymaraldehyde, ndi glutaraldehyde. Ndiotetezeka bwino, chifukwa chake glutaraldehyde amagwiritsidwa ntchito ngati wothandizira wogwirizanitsa wa mtandawo. Kuchuluka kwa nthumwi yolumikizirana pamtanda mu njirayo nthawi zambiri kumakhala 7 mpaka 10% ya kulemera kwa ether. Kutentha kwamankhwala kuli pafupifupi 0 mpaka 30 ° C, ndipo nthawi ndi mphindi 1 ~ 120]. Kulumikizana kolumikizana kumafunikira kuchitika pansi pa acidic mikhalidwe. Choyamba, a anorganic acid acid kapena organic Carboxyylic acid amawonjezeredwa ku yankho kuti asinthe PH ya yankho la 4-6, kenako Aldehydes amawonjezeredwa kuti akwaniritse zomwe zidalipo [Chithunzi patsamba 32). Acids omwe amagwiritsidwa ntchito amaphatikiza hcl, h2SO4, acetic acid, citric acid, ndi zina. Acid ndi Aldeyde imathanso kuwonjezeredwanso nthawi yomweyo kuti ipange yankho kukwaniritsa zomwe zimachitika mu ma ph.

1.3 mankhwala a antioxidantives a hydroxypropyll methylcellulose mafilimu

Hydroxypypyl methylclulose ndi chuma, chosavuta kupanga filimu, ndipo ali ndi mwayi wogwira bwino ntchito. Monga chosungira chakudya, ili ndi chitukuko chachikulu [34-36].

Zhung Rongyu [37] anagwiritsa ntchito hydroxpyl methylcellulose (phwetekere) Zotsatirazi zikuwonetsa kuti kuuma kwa phwetekere ndi zokutira kwa HPMC ndikokwera kuposa zokutira. Zinatsimikiziridwanso kuti filimu ya HPMC imatha kuchedwetsa kusintha kwa mtundu wa phwetekere kuchokera ku pinki mpaka yofiyira ikasungidwa pa 20 ℃.

[38] anaphunzira zotsatira za hydroxypropyl methylcellulose (hpmc) mankhwala okangana, anthocnin synthesis ndi ntchito ya antioxidant ya "Wuzhong" BayBerberry Chipatso chosungira nthawi yozizira. Zotsatira zake zidawonetsa kuti anti-octidation magwiritsidwe a bayorberry omwe amathandizidwa ndi HPMC adasinthidwa, komanso kuchuluka kwa kuwonjezeka nthawi ya filimu ya 5% HPMC inali yabwino kwambiri.

Wang Kaikai et al. [39] ntchito. Zotsatira zake zidawonetsa kuti zipatso zophatikizika za riboflavin-zophatikizika zimagwira ntchito kwambiri kuposa zokutira limodzi ndi riboflavin kapena hpmc, moyenera kuchepetsa zipatso za zipatso za zipatso, motero zimatenga nthawi yosungirako zipatso.

M'zaka zaposachedwa, anthu ali ndi zofunikira komanso zapamwamba kuti pakhale chakudya. Ofufuza kunyumba ndi kunja pang'onopang'ono adasinthitsa kafukufuku wawo pazakudya zowonjezera pazowonjezera. Powonjezera kapena kupopera ma antioxidants m'matope, amatha kuchepetsa mafuta oxidation. Kuchuluka kwa kuvunda [40]. Antioxidants achilengedwe akhala akumadera kwambiri chifukwa chotetezeka komanso zotsatira zaumoyo wa thupi la munthu [4011].

Antioxidant ya masamba a bamboo (Amob form) ndi antioxidant wachilengedwe wokhala ndi kununkhira kwapadera kwa bambondo ndi madzi abwino. Inalembedwera ku National GB2760 ndipo yavomerezedwa ndi utumiki wathanzi monga antioxidant chakudya chachilengedwe. Itha kugwiritsidwanso ntchito ngati chakudya chowonjezera cha nyama, zinthu zopangidwa kum'madzi komanso chakudya chofukizira [42].

Dzuwa Lina etc. [42] anawunikiranso zigawo zazikulu ndi katundu wa masamba a arboaf antioxidants ndikuyambitsa ntchito ya bamboo onfoxidal. Kuphatikiza 0.03% AOB kupita ku mayonesi atsopano, antioxidant zotsatira ndizodziwikiratu panthawiyi. Poyerekeza ndi tiyi ofanana tiyi antioxidants, antioxidant yake mwachionekere ndiyabwino kuposa ya tiyi ma polyphenols; Kuphatikiza 150% kupita ku mowa ku mg / l, ma antioxidant katundu ndi kukhazikika kwa mowa kumachulukitsa, ndipo mowa umakhala ndi thupi labwino. Pomwe akuwonetsetsa kuti thupi loyambirira loyambirira la vinyo, limawonjezeranso kukoma ndi kukoma kwa bonga la nsungwi lamanzere [43].

Mwachidule, hydroxypropyl methylcellulose ali ndi mawonekedwe abwino opanga mafilimu komanso magwiridwe antchito abwino. Ndi zinthu zobiriwira komanso zofiirira, zomwe zingagwiritsidwe ntchito ngati kanema wa matsamu m'munda wa ma CD. Glycerol ndi sorbitol ndi mapiko onse osungunuka madzi. Kuonjezera glycerol kapena sorbitol to the cellulose njira yopanga ma cellulose ingathe kusintha mawonekedwe a hydroxypropyl ficy filimu, potero kuwonjezereka mtunda wophwanyika pa filimuyo [49-51]. Glutaraldehyde amagwiritsidwa ntchito kawirikawiri mankhwala opha tizilombo toyambitsa matenda. Poyerekeza ndi Aldwahydes ena, ndi gulu la anthu ambiri mu molekyulu, ndipo liwiro lolumikizirana limathamanga. Itha kugwiritsidwa ntchito ngati kusintha kwa ma hydroxypropyl filimu. Itha kusintha madzi osungunuka a filimuyo, kuti filimuyo itha kugwiritsidwa ntchito kangapo [52-55]. Kuphatikiza masamba a armboxidants ku hydroxypropyl filimuyo kuti apititse patsogolo mitundu ya ma hydroxygyulose filimu filimu ndikuwonjezera ntchito yake pakupanga chakudya.

1.4 lingaliro la mutuwo

Kuchokera pa kafukufuku wapano, mafilimu osungunuka amadzi makamaka amapangidwa ndi mafilimu a PV, mafilimu a peo, okhazikika ndi mapuloteni osungunuka-madzi osungunuka. Monga nkhani yochokera ku petroleum, pva ndi peo ndi zinthu zosakhala zatsopano, ndipo kupanga zikwangwani zawo zitha kuipitsidwa. Ngakhale United States, Japan ndi mayiko ena alembapo kanthu monga poizoni, chitetezo chake chikadaliponso. Ma inhalation inhalation ndi kulowetsedwa ndizovulaza thupi [8], ndipo silingatchedwa chemistry yathunthu yobiriwira. Kupanga zida zokhazikika ndi zosungunulira ndi mapuloteni ndizosavulaza ndipo malonda ndi otetezeka, koma ali ndi zovuta za mapangidwe olimba a filimu, mtunda wotsika, komanso kusweka kosavuta. Chifukwa chake, nthawi zambiri, ayenera kukhala okonzekera kuphatikizidwa ndi zinthu zina monga Pva. Mtengo wogwiritsira ntchito si wapamwamba. Chifukwa chake, ndikofunikira kwambiri kukulitsa mawonekedwe a kanema watsopano, wosinthika wamadzi omwe ali ndi magwiridwe antchito abwino kuti musinthe zilema za filimu yomwe ilipo.

Hydroxypypyl methylcellulose ndi zinthu zachilengedwe zachilengedwe, zomwe sizongokhala zofunikira pazinthu, komanso zotheka. Ili ndi madzi abwino osungunuka ndi mawonekedwe a makanema, ndipo ali ndi zofunikira kukonza mafilimu osungunuka. Chifukwa chake, pepala ili limafuna kukonzekera mtundu watsopano wa makanema osungunuka ndi hydroxypylluloulose yopanga zinthu zosaphika, ndikukhazikitsa mwadongosolo ma pulasitiki ake okonzekera komanso kuchuluka kwa ma pulasitiki yoyenera (glycerol ndi sorbitol). ) Othandizirani othandizira (glutaraldehyde), antioxidant leaf antioxidant), ndikusintha katundu wawo, kuti akonzekere katundu wa hydroxym, solubidantant katundu. Methylcellulose madzi filimu yosungunuka ndi yofunika kwambiri kuti igwiritsidwe ntchito ngati filimu yosungunuka yamadzi.

1.5 Zofufuzira

Zamaphunzirowa ndi awa:

1) Kanema wosungunuka wa HPMC adakonzedwa ndi njira yopangira njira yopanga filimu, ndipo mawonekedwe a filimuyo adasanthuliridwa kuti aphunzire kuchuluka kwa kuchuluka kwa kuchuluka kwa filimu ya HPMC yamadzi osungunuka.

2) Kuti muphunzire zovuta za glycerol ndi sorbitol mavioni opanga, kusungunuka kwamadzi ndi mafilimu osungunuka a HPMC.

3) Kuti muphunzire mphamvu ya wothandizira wa glutarardeldel soldeldel pamadzi kusungunuka madzi, makina, makina ndi mafilimu osungunuka a HPMC.

4) Kukonzekera kwa AOB / HPMC Field Field. Kukaniza kwa oxidation, kusungunuka kwamadzi, makina, makina ndi mafilimu obzala a AOB / HPMC owonda adaphunziridwa.

MUTU 2 Kukonzekera ndi Katundu wa Hydroxypropyll Mealulose Makina Osungunula Madzi

2.1 Kuyamba

Hydroxypypyl methylcellulose ndi chilengedwe cha cellulose. Ndiwosakayika, osadetsedwa, okhazikika, okhazikika, komanso amasungunuka madzi ndi madzi abwino. Ndi nkhani yosungunuka yamadzi yosuta.

Mutuwu ugwiritsa ntchito hydroxpyl methylcelulose monga rawroxypropyl osinthana ndi mafilimu a 2%, kutentha kwa mafilimu pa filimu, koloko, ndi madzi osungunuka. Kanema wa kanemayo adadziwika ndi kusiyanasiyana kwa X-ray, ndipo mphamvu yakuwoneka bwino, yopingasa yopuma ndi ma hydroxyprose yoyeserera, mayeso oyeserera ndi madzi.

2.2 Kupeza Kuyesera

2.2.1 Zipangizo zoyesera ndi zida

2.2.2 Kukonzekera kwa centonen

1) Zolemera: Kuyeza kuchuluka kwa hydroxypypyl methylcellulose ndi njira yamagetsi.

2) Kusintha kwa meth hydrocropyl meth nembanei madzi. Zopangidwa pa 2%, 3%, 4%, 5% ndi 6%.

3) Mapangidwe a makanema: The hydroxypypyuropyl methyllulose madzi-kusungunuka ka makanema a 25-50 μm amakonzedwa, ndipo filimuyo imasungidwa ndikuyika mu bokosi louma kuti mugwiritse ntchito. Kutentha kwa mafilimu oonda m'mafilimu osiyanasiyana opanga mafilimu (kutentha kwa filimu) The hydroxypropyl methyllulose madzi osungunuka madzi ndi filimu ya 45 μm idakonzedwa, ndipo filimuyo idayang'aniridwa ndikuyika mu bokosi louma kuti mugwiritse ntchito. Wokonzekera hydroxypropyl me methylcelulose madzi-suluble contagrag amatchedwa filimu ya HPMC kuti iperechedwe.

2.2.3 mapangidwe ndi muyeso wa magwiridwe antchito

2.2.3.1

Kusakanikirana kwakukulu kwa angle (xrd) kusanthula kwa Crystalline chinthu pamlingo wa maselo. Mtundu wa X-ray Disfractometer ya Arl / Xtra mtundu wopangidwa ndi gulu la Thermo Arl kampani ku Switzerland idagwiritsidwa ntchito kutsimikiza mtima. Miyezo Yoyenerera: Wolemba X-Ray anali mzere wosefedwa ndi undickel (40kv, 40ma). Makona a scan ndi ochokera ku 0 ° mpaka 80 ° (25). Scanning kuthamanga 6 ° / min.

2.2.3.2 Makina Overties

Mphamvu yakuwoneka ndi kutalika kopumayo imagwiritsidwa ntchito ngati njira zopezera zinthu zamakina, ndipo mphamvu yakuwoneka bwino (yopepuka) ikutanthauza kusintha kwa pulasitiki yayikulu, ndipo unit ndi MPA. Elongition pa break (kuthyolako elongition) imatanthawuza kuchuluka kwa mtunda wautali pomwe filimuyo idawonongeka kutalika koyambirira, yofotokozedwa%. Kugwiritsa ntchito makina a Insron (5943) amagetsi amagetsi a TV.

2.2.3.3 Optical katundu

Malo owoneka bwino ndi chizindikiro chofunikira kwambiri cha mawonekedwe a mafilimu a Paketi, makamaka kuphatikizapo kuphatikizika ndi filimuyo. Kuphatikizika kwa mafilimuwa kumayesedwa pogwiritsa ntchito Conters Confent. Sankhani zitsanzo zoyeserera ndi mawonekedwe oyera ndipo palibe zopota, ziikeni pang'ono pa mayeso, konzani ndi chikho chopepuka, ndikuyeza filimuyo firiji (25 ° C ndi 50% RH). Chitsanzo chimayesedwa katatu ndipo mtengo wamba umatengedwa.

2.2.3.4 Kusungunuka kwamadzi

Dulani filimu ya 30mm × 30μm, onjezani madzi okwanira 200ml, ikani filimuyo mkati mwa madziwo, ndikuyesa nthawi kuti filimuyo ithe [56]. Samwali iliyonse idayeza katatu ndipo mtengo wamba udatengedwa, ndipo um'mimba udali mphindi.

2.2.4 Kusintha deta

Zoyeserera zoyesera zidakonzedwa ndi Excel ndi Pulogalamu Yoyambira.

2.3 zotsatira ndi zokambirana

2.3.1.1 Xrd mafilimu owonda a HPMC owonda pansi pa njira yosinthira filimu yokhazikika

Mkuyu.2.1 xrd ya HPMC Filimu Yosiyanasiyana ya HP

Kusakanikirana kwakukulu kwa ma anger x-ray ndikuwunika kwa ma crystalline zinthu zamitundu yocheperako. Chithunzi 2.1 ndi gawo la Xrd losiyanasiyana la mafilimu oonda a HPMC pansi pa njira yosinthira filimu yokhazikika. Pali nsonga ziwiri zosiyanasiyana [57-59] (pafupi 9.5 ° ndi 20,4 °) filimu ya HPMC yomwe ili. Itha kuwoneka kuchokera ku chiwerengero chomwe ndikuwonjezera kwa HPMC ndende, nsonga yosiyanasiyana ya filimu ya HPMC pafupifupi 9.5 ° ndi 20,4 ° imalimbikitsidwa. Ndipo kenako anafooka, kuchuluka kwa madongosolo owongolera (oyitanitsa) okwera koyamba kenako anachepa. Pamene ndende ili 5%, makonzedwe a HPMC mamolekyulu ndi oyenera. Zomwe zidali pamwambapa zitha kukhala kuti ndikuwonjezeka kwa HPMC ndende, chiwerengero cha Crystal cha Crystal mu yankho la filimu limachuluka, ndikupanga makonzedwe a HPM moleclal. Pamene hpmc ndende imaposa 5%, yofananira ya XD yosiyanasiyana ya filimuyo imafooketsa. Kuchokera pakuwona makonzedwe a madole, pomwe HPMC imakhala yayikulu kwambiri, mafayilo opanga mafilimuwo ndi okwera kwambiri, ndikupangitsa kuti unyolo ukhale wosunthatu, ndikupangitsa kuti mafilimu a HPMC adachepa.

2.3.1.2 Njira zopangira mafilimu oonda hpmc pansi pa njira yosinthira filimu yokhazikika.

Mphamvu yakuwoneka ndi kutalika kopuma imagwiritsidwa ntchito ngati njira yoweruza mphamvu zake, ndipo mphamvu ya tunsile imakhala ndi nkhawa yomwe filimuyo imapanga kufooka kwapulasitiki yayikulu. Chofungukapo nthawi yopuma ndi chiwerengero chazosamukira ku kutalika kwa filimuyo nthawi yopuma. Kukula kwa makina opanga a filimuyo kumatha kuweruza ntchito yake m'minda.

Mkuyu.2.2 Zotsatira zoyipa za HPMC pa makina opanga mafilimu a HPMC

Kuchokera mkuyu. 2.2, kusintha kwamphamvu kwa mphamvu ya anthu ndikuphwanya kanema wa HPMC pansi pa njira yosinthira HPMC yowonjezereka yankho la HPMC. Njira yothetsera vutoli ndi 5%, makinawo amakina a mafayilo a HPMC ali bwino. Izi ndichifukwa choti mafilimu omwe amapanga madzi ambiri ali otsika, njira yothetsera vutoli ndi yotsika, kulumikizana pakati pa madolecular sikungathetsedwe mwadongosolo, kotero mphamvu zake ndi zosauka; Pamene filimuyo imapangidwa ndi madzi ndi 5%, makina amakina kuti akwaniritse mtengo wabwino; Pamene kuchuluka kwa mawonekedwe opanga mafilimu kumapitilirabe, kuponyera ndi kusanja kwa njira yovuta kwambiri, chifukwa cha kufooka kwa HPMC ndi kutsika kwa makina a HPMC. Chifukwa chake, kuchuluka kwa kuchuluka kwa mafilimu a 5% HPMC ndikoyenera kwambiri. Kuchita kwa filimu yomwe yapezeka ilinso yabwino.

2.3.1.3 Zowopsa za mafilimu owonda a HPMC pansi pa njira yosinthira filimu yokhazikika

Mu mafilimu a matepu, kuwala kopepuka komanso kude kwa ma coze ndi gawo lofunikira lomwe likuwonetsa kuwonekera kwa filimuyo. Chithunzi 2.3 chikuwonetsa kusintha kwa zochitika za kupatsirana kwa HPMC mafilimu omwe ali pansi pa filimu yosiyanasiyana. Itha kuwoneka kuchokera ku chiwerengero chomwe ndikuwonjezeka kwa kuchuluka kwa njira yopanga HPMC pang'onopang'ono, pang'onopang'ono ndikuwonjezeka kwambiri ndi kuchuluka kwa yankho la filimu.

Mkuyu.2.3 Zotsatira zoyipa za HPMC pa Chuma cha HPMC cha HPMC

Pali zifukwa ziwiri zazikulu: Choyamba, kuchokera ku malingaliro a chiwerengerochi chomwe chikuphatikizidwa, kuchuluka kwa ndende kumakhala kotsika, kuchuluka kwazomwe zimathandizira kwambiri pazinthu [61]. Chifukwa chake, pochulukitsa kwa kuchuluka kwa njira yopangira mafilimu ya HPMC, matayala a kafilimuyo amachepetsedwa. Kuwala kopepuka kunachepa kwambiri, ndipo tsitsi limakwera kwambiri. Chachiwiri, kuchokera pakuwunikira kwa njira yopanga filimuyi, atha kukhala chifukwa filimuyo idapangidwa ndi yankho likutulutsa njira yopanga filimu. Kuchuluka kwa zovuta za mlengalenga kumabweretsa kuchepa kwa filimuyo ndi kuchepa kwa mawonekedwe a kanema wa HPMC.

2.3.1.4 Kusungunuka kwamadzi kwa mafilimu owonda a HPMC pansi pa filimu yosiyanasiyana

Kusungunuka kwamadzi kwa mafilimu osungunuka kumayenderana ndi mawonekedwe awo opanga mafilimu. Dulani 30mm × 30mm × 30mm mafilimu opangidwa ndi filimu yopanga filimu yokhazikika, ndikulemba kanemayo ndi "+" kuti muyeze nthawi kuti filimuyo ithe. Ngati filimuyo kapena imamatira kumakhoma a chomera, mobwerezabwereza. Chithunzi 2.4 Kodi chithunzi cha kusinthika kwa madzi osungunuka cha HPMC pansi pa filimu yosiyanasiyana yamafuta. Itha kuwoneka kuchokera ku chithunzi chomwe ndikuwonjezera madzi opanga mafilimu, nthawi yosungunuka yamadzi ya HPMC imayamba nthawi yayitali, yosonyeza kuti madzi osungunuka a HPMC amatsika. Amaganiziridwa kuti chifukwa chake ndikuwonjezeka kwa kuchuluka kwa njira yopangira HPMC, mafayilo amalimbikitsidwa pambuyo pa mafuta a HPMC m'madzi ndi kuchepa kwa madzi kususuka.

Mkuyu.2.4 Zotsatira zoyipa za HPMC pamadzi osungunuka a HPMC

2.3.2

2.3,1

Mkuyu.2.5 xrd ya HPMC ka makanema pansi pa filimu yosiyanasiyana

Chithunzi: Mitengo iwiri yosiyanasiyana ya 9.5 ° ndi 20.4 idasanthuliridwa filimu ya HPMC. Kuchokera pakuwona kwamphamvu kwa mapiri osiyanasiyana, ndi kuwonjezeka kwa kutentha kwa mafilimu, nsonga zosiyanasiyana zimawonjezereka kenako ndikuletsedwa, ndi luso la crystallotion yowonjezereka kenako ndikuchepa. Kutentha kwa mafilimu ndi makonzedwe a HPMC mamolekyulu ochokera ku ma molekyulu ochuluka, pomwe kutentha kumakhala kochepa, ndipo makristal ndi ovuta; Pamene kutentha kwa mafilimu kumawonjezeka pang'ono, kuchuluka kwa nyukiliya kumawonjezera, kuyenda kwa telecular timenti kumakonzedwa mosavuta kuzungulira kwa dongosolo la galasi, motero therstallization lifika mtengo wokwanira pamtunda wina; Ngati kutentha kwa mafilimu kuli kwakukulu kwambiri, mayendedwe ake ndi ovuta kwambiri, mapangidwe a crystal ndi ovuta, ndipo mapangidwe a nyukiliya ali otsika ndipo ndikovuta kupanga makhiristo [62,63]. Chifukwa chake, makilogalamu a rpmc amakula koyamba kenako amachepetsa ndi kuchuluka kwa kanema wopanga kutentha.

2.3.2.2 Njira zamakina za mafilimu oonda hpmc ku filimu yosiyanasiyana yopanga kutentha

Kusintha kwa mawonekedwe a filimuwo kumakhala ndi chipongwe china chilichonse pa makina opanga. Chithunzi 2.6 chikuwonetsa kusintha kwamphamvu kwa mphamvu ya tansile ndikusintha mafilimu a HPMC pa filimu yosiyanasiyana yopanga kutentha. Nthawi yomweyo, zimawonetsa zomwe zikuwonjezereka kenako ndikuchepetsa. Pamene filimu yopanga kutentha inali 50 ° C, Mphamvu yakuwoneka ndipo kutalika kosweka kwa kanema wa HPMC idafika pamakhalidwe okwanira, omwe anali a 116%, motsatana.

Mkuyu.2.6 Zotsatira za filimu yopanga kutentha kwa makina a HPMC

Kuchokera m'makonzedwe a moleclar, omwe amakonzedwa mwadongosolo la mamolekyulu, kukhala abwino kwambiri kukhala mphamvu [64]. Kuchokera mkuyu. 2,5 xrd forters a hpmc mafilimu osiyanasiyana amakanema, imatha kuwoneka kuti ndi kutentha kwa mafilimu, dongosolo la mamolekyulu ya HPMC koyamba limawonjezeka kenako amachepetsa. Pamene kutentha kwa makanema ndi 50 ° C, kuchuluka kwa dongosolo lomwe adayitanitsa ndiye lalikulu kwambiri, motero kulimba kwa mafilimu a HPMC koyamba kumawonjezeka kenako ndikuwonjezeka kwa filimuyo yopanga kutentha kwa 50 ℃. Kukula kwa nthawi yopuma kumawonetsa zomwe zikuwonjezereka kenako ndikuchepetsa. Cholinga chake chikhoza kukhala kuti ndi kuchuluka kwa kutentha, makonzedwe a mamolekyulu amayamba kuwonjezereka kenako amachepetsa, ndipo ma squameline opangidwa mu polymer matrix amabalalitsidwa ndi polymer matrix. Mu matrix, malo olumikizidwa pachimake amapangidwa, omwe amakonda kugwira ntchito mokhumudwitsa pa filimu ya HPMC kuti iwoneke paphiri la filimu ya 50 ° C.

2.3.2.3 Zosangalatsa za HPMC za HPMC pa filimu yosiyanasiyana yopanga kutentha

Chithunzi 2.7 ndikusintha kwa mawonedwe a mafilimu a HPMC pa filimu yosiyanasiyana yopanga kutentha. Itha kuwoneka kuchokera pa chiwerengerocho chomwe ndikuchulukitsa kwa kutentha kwa filimu, kupatsirana kwa filimuyi pang'onopang'ono kumawonjezeka, pang'onopang'ono pang'onopang'ono kumachepa, ndipo zowoneka bwino za filimuyo pang'onopang'ono zimakhala bwino.

Mkuyu.2.7 Zotsatira za filimu yopanga kutentha pa katundu wa HPMC

Malinga ndi mphamvu ya kutentha ndi mamolekyulu amadzi pa filimu [66], pomwe matentheki amapezeka mu hpmc mu mawonekedwe amadzi omangidwa, koma HPMC ili pamtunda wagalasi. Volatilolization wa filimuyo amapanga mabowo ku HPMC, kenako kufalitsa zimapangidwa kumabowo pambuyo pa kufalikira kwa mafilimuwo ndi kutsika; Kutentha kumawonjezeka, zigawo za HPMC zimayamba kusuntha, mabowo amayamba kusunthidwa, mabowo amachepetsa pang'ono, ndipo mabowo amachepetsa [mphamvu yowunikira ikuwonjezeka.

2.3.2.4 Kusungunuka kwamadzi kwa mafilimu a HPMC pa filimu yosiyanasiyana yopanga kutentha

Chithunzi 2.8 chikuwonetsa ma curves a madzi a HPMC pa filems ya filimu yosiyanasiyana. Itha kuwoneka kuchokera pa chiwerengero chomwe madzi osungirako madzi a HPMC amawonjezeka ndi kuchuluka kwa kanema wopanga, ndiye kuti, kusungunuka kwamadzi kwa mafilimu a HPMC kumakulirakulira. Ndi kuwonjezeka kwa kutentha kwa mafilimu, kuchuluka kwa mamolekyulu amtundu wa ma mamolekyulu okwera, kuyenda kwa matope amachepetsedwa, ndipo zimapangitsa kuti zikhale zovuta kwambiri, zomwe zimapangitsa kuti zikhale zovuta kwa mamolekyulu amadzi kuti alowe pakati pa mamolekyu a HPMC. Kusungunuka kwamadzi kumachepetsedwanso.

Mkuyu.2.8 Zotsatira za filimu yopanga kutentha kwa madzi osungunuka kwa HPMC

2.4 Chidule cha chaputala ichi

M'mutu uno, hydroxypropyl methylcellulose idagwiritsidwa ntchito ngati zosaphika kuti mukonzekere filimu ya HPMC-soluble pogwiritsa ntchito njira yopangira filimu. Mtsogoleri wa kanema wa HPMC adasanthuridwa ndi kusiyanasiyana kwa Xrd; Makanema osinthika a HPMC Madzi osungunuka adayesedwa ndikusanthula makina oyesera a Micro-Excronic a Universile, ndipo zojambula zamagetsi za HPMC idasanthula ndi njira yowunikira. Nthawi yofatsayo m'madzi (nthawi yosungira madzi kusubilili) amagwiritsidwa ntchito pofufuza kuwonongeka kwa madzi. Malingaliro otsatirawa amakokedwa kuchokera ku kafukufukuyu:

1) Makina omwe amagwiritsa ntchito mafilimu a HPMC koyamba adayamba kuwonjezeka ndikuchepetsa ndikuwonjezeka kwa kuchuluka kwa yankho la filimu, ndipo adakwera koyamba ndikuchepetsa kutentha kwa filimuyo. Pamene kuchuluka kwa njira ya HPMC inali 5% ndipo kutentha kwa mafilimu kunali 50 ° C, makina a filimuyo ndi abwino. Pakadali pano, kulimba kwamphamvu kuli pafupifupi 116mmka, ndi mtunda wa nthawi yopuma ndi pafupifupi 31%;

2) Zowoneka za mafilimu a HPMC zimatsika ndi kuwonjezeka kwa njira yogwiritsira ntchito filimuyo, ndipo pang'onopang'ono ndikuwonjezeka ndi kuwonjezeka kwa kutentha kwa mafilimu; motsimikiza amalingalira kuti kuchuluka kwa njira yopanga filimu sikuyenera kupitirira 5%, ndipo kutentha kwa mafilimu sikuyenera kupitirira 50 ° C

3) Madzi osungunuka a HPMC adawonetsa momwe adawonekera pansi ndikuwonjezeka kwa kuchuluka kwa njira yopanga filimuyo ndikuwonjezeka kwa kutentha kwa mafilimu. Pamene ndende ya 5% hpmc yankho la filimu ya mafilimu ndi kutentha kwa filimu ya 50 ° C idagwiritsidwa ntchito, nthawi yosungunuka madzi inali 55 min.

MUTU 3 Zotsatira za Mafupa pa Mafupa za HPMC Madzi osungunuka

3.1 Chiyambi

Monga mtundu watsopano wa filimu yachilengedwe ya Polymec Holtured-soluble madzi ali ndi chiyembekezo chabwino. Hydroxypypyl methylcellulose ndi chilengedwe cha cellulose. Sikuti sizakuwaza, osasunthika, okhazikika, okhazikika amtundu, ndipo ali ndi zinthu zabwino. Kusungunuka kwamadzi ndi mawonekedwe a filimu, ndi zinthu zosungunulira zamadzi zomwe zingachitike.

Mupuputala chapitachi adafotokoza za filimu yosungunuka ya HPMC yosungunuka pogwiritsa ntchito hydroxpyulosi yopanga njira yopangira mafilimu komanso filimu ya filimu yosungunuka. zomwe zimachitika. Zotsatira zikuwonetsa kuti kulimba kwa filimuyo kuli pafupifupi 116mm ndi mtunda wa nthawi yopuma ndi 31% pansi pa chida chokhazikika komanso mikhalidwe. Kuumitsidwa kwa mafilimu oterowo siofatsa pamapulogalamu ena ndikufunika kusinthanso.

Mu mutu uno, hydroxypropyl methylcellulose akugwiritsidwabe ntchito ngati zopangira, ndipo filimu yosungunuka imakonzedwa ndi njira yopangira njira yopangira filimu. , oyambira nthawi yopuma), owoneka bwino (kupatsirana, kudeza) ndi kuthina madzi kusandulika.

3.2 Dipatimenti Yoyesera

3.2.1 Zipangizo zoyesera ndi zida

Gome 3.1 Zoyeserera ndi Zizindikiro

Gome 3.2 Zida Zoyesa ndi Zosayina

3.2.2 Kukonzekera kwachitsanzo

1) Kuyeza: Yendani kuchuluka kwa hydroxypylllulose (5%) ndi sorbitol (0.05%, 0.85%, 0.15%, 0,35%, 0.45%).

2) Kufalikira: Onjezani meth hydrocyllulolidese ya madzi okonzedwa m'madzi okonzedwa, akusungani kutentha kwabwino kwambiri mpaka atasungunuka kwathunthu, kenako kuwonjezera glycerol kapena sorbitol mosiyanasiyana. Mu hydroxypropyll methylcellulose yankho, kusunthira kwakanthawi kuti ayimitsire mphindi 5 (kulongedza) kuti apeze madzi opanga filimu.

3) Kupanga makanema: jekeseni madzi opanga filimuyo mu mbale ya petri ndi kuponyera filimu, muimeni mu nthawi yowuma ndikupanga filimuyo kuti ipange kanema wa 45 μm. Kanemayo atayikidwa mu bokosi louma kuti mugwiritse ntchito.

3.2.3 mapangidwe ndi kuyesedwa kwa magwiridwe antchito

3.2.3.1 infrated matchroscopy (FT-IR)

Infrated mayamwidwe sloptroscopy (ftir) ndi njira yamphamvu yofotokozera magulu omwe amagwira ntchito molecular wopanga ndi kuzindikira magulu ogwira ntchito. Mayamwidwe a infrator omwe amapezeka mufilimu ya HPMC adayeza pogwiritsa ntchito Nicolet 5700 amasinthira mawonekedwe a a Theroelectomern. Njira yopyapyala idagwiritsidwa ntchito poyesa iyi, mawonekedwe a Scanning anali 500-4000 cm-1, ndipo mafilimu achinsinsi adawuma mu uvuni wowuma pa 50 h for a infradropy.

3.2.3.2

3.2.3.3 kutsimikiza kwa makina

Mphamvu yamphamvu ndi mmodzi yotsekera pa filimuyi imagwiritsidwa ntchito ngati gawo loweruza makina ake. Kukula kwa nthawi yopuma ndi gawo lazosamukira ku kutalika koyambirira pomwe filimuyo imasweka, in%. Kugwiritsa ntchito makina oyesa makompyuta (5943) amagetsi a Insron (Shanghai) zida zoyeserera, molingana ndi 25 ° Chter)

3.2.3.4 Kutsimikiza kwa mitengo yamako: chimodzimodzi ngati 2.2.3.3

3.2.5.5 kutsimikiza kwa madzi kususuka

3.2.4 Kusintha kwa data

Zoyeserera zidakonzedwa ndi Excel, ndipo graph idakopeka ndi mapulogalamu.

3.3 zotsatira ndi zokambirana

3.3.1 Zotsatira za glycerol ndi sorbitol pa mayamwidwe azomwe amathandizira mafilimu a HPMC

(a) glycerol (b) sorbitol

Mkuyu.3.1 FT-IR ya mafilimu a HPMC pansi pa glycerol kapena sorbitolum neya

Infrated mayamwidwe sloptroscopy (ftir) ndi njira yamphamvu yofotokozera magulu omwe amagwira ntchito molecular wopanga ndi kuzindikira magulu ogwira ntchito. Chithunzi 3.1 chikuwonetsa Spectra ya HPMC ya HPMC yokhala ndi zowonjezera zosiyanasiyana za glycerol ndi sorbitol. Itha kuwoneka kuchokera ku chiwerengero chomwe chimakhala cha Puketon Trugration Philal of HPMC makamaka m'magawo awiriwa: 2600 ~ 3700cm-1

Mabatani oyandama apafupi amayambitsidwa ndi kugwedezeka kwa mawu a oh wolumikizana, 2935cm-1 ndi mayamwidwe a - 157cm- 1 ndi -cocm-1 ndi gulu la 1 ndi loyatsa. Mayamwidwe a gulu la hydroxyl mu kugwedezeka kwa chimango, 945cm-1 ndikuyamwa kuyamwa kwa -ch3 [69]. Mayamwidwe a pa 1454cm-1, 13732cm-1, 1315cm-1 ndi 945cm-1 amatumizidwa ku ziphuphu za asymmetric, ndege ndi ndege zomangira za -ch3]. Pambuyo pa pulasitiki, palibe mayamwa atsopano omwe amapezeka mufilimuyo, zomwe zikuwonetsa kuti HPMC sinasinthe, ndiye kuti, pulawo silinawononge kapangidwe kake. Ndi kuwonjezera kwa glycerol, kugwedezeka kwamphamvu kwa -O pa 3418cm-1 ya HPMC-1 ya HPMC-1 Ndi kuwonjezera kwa sorbitol filimu ya HPMC, nsonga-yotambalala ya-yotambalala pa 3418cm-1 yofooka, ndipo mayamwidwe a 1657cm-1 ofooka. . Zosintha za mayamwidwe izi zimachitika makamaka chifukwa cha zovuta ndi zophatikizira hydrogen, zomwe zimapangitsa kuti zisinthe ndi zoyandikana ndi -ch3 ndi -ch2. Chifukwa cha zazing'ono, kulowetsa ma molecular zinthu zomwe zimalepheretsa mapangidwe a ma bale entermolecular hydrogen, kotero kulimba kwa filimu ya pulasitiki kumatsika [70].

3.3. Zotsatira za glycerol ndi sorbitol pazenera za Xrdc a HPMC

(a) glycerol (b) sorbitol

Mkuyu.3.2 Xrd ya HPMC Filimu Yosiyanasiyana ya Glycerol kapena Sorbitolum anderra

Kusakanikirana kwakukulu kwa X-ray (Xrd) Kusanthula Starstalline Starffent for for for form. Mtundu wa X-ray Disfractometer ya Arl / Xtra mtundu wopangidwa ndi gulu la Thermo Arl kampani ku Switzerland idagwiritsidwa ntchito kutsimikiza mtima. Chithunzi 3.2 ndi njira ya xrd ya mafilimu a HPMC yokhala ndi zowonjezera zosiyanasiyana za glycerol ndi sorbitol. Ndi kuwonjezera kwa glycerol, kukula kwa nsonga zamitundu ya 9,5 ndi 20.4 ° zonse zofooka; Ndi kuwonjezera kwa sorbitol, pamene kuchuluka kwa zinthu kunali 0,15%, kusiyanasiyana kwa 9,5 ° kudakuletsedwa pa 20.4 Ndi kuwonjezera kosalekeza kwa sorbitol, kusiyanasiyana kosiyanasiyana 9.5 ° kudachepa kachiwiri, ndipo nsonga yosiyanasiyana 20,4 ° idasinthiratu. Izi ndichifukwa choti kuwonjezera kwa mamolekyulu ang'onoang'ono a glycerol ndi sorbitol kumasokoneza dongosolo la ma unyolo ndikuwononga mawonekedwe oyambilira, potero kuchepetsa makhlamu. Itha kuwoneka kuchokera ku chithunzi chomwe Glycelol chili ndi mphamvu kwambiri pa mafayilo a HPMC, zomwe zikuwonetsa kuti glycerol ndi hpmc ali ndi luso labwino, pomwe Hopmc ali ndi luso logwirizana. Kuchokera pakuwunikira kwazinthu zamafupa, sorbitol ali ndi mawonekedwe a shuga ofanana ndi cellulose, komanso kulepheretsa kwambiri ma molekyulu ndi ma cellulose, motero sizikukhudza cellolilization crystallization.

48].

3.3.3 zotsatira za glycerol ndi sorbitol pa makina ojambula a HPMC

Mphamvu yamphamvu ndi mmodzi yopuma pa filimuyi imagwiritsidwa ntchito ngati magawo kuti aweruze zinthu zake zamakina, ndipo kuchuluka kwa makina amatha kuweruza ntchito yake m'minda inayake. Chithunzi 3.3 chikuwonetsa kusintha kwamphamvu kwamphamvu ndikuphwanya mafilimu a HPMC mutatha kuwonjezera mafayilo.

Mkuyu.3.3 Zotsatira za Glycerol kapena Sorbitolumon pa makina a HPMC

Itha kuwoneka kuchokera pa Chithunzi 3.3 (a) kuti ndi kuwonjezera kwa glycerol, mtunda wotamandira wa HPMC koyamba amatsika mwachangu, kenako ndikuwonjezeka pang'ono kenako ndikupitilirabe. Kukula kwa HPMC Filimu filimu yoyamba kuwonjezeka kenako kutsika, chifukwa glycerol imakhala ndi magulu a hydrophilic ambiri, omwe amapanga mamolekyulu amadzi ali ndi mphamvu yosinthika. Ndi kuwonjezeka kosalekeza kwa glycerolor kuwonjezera, kutalika komwe kumatha kwa kanema wa HPMC kumachepa, izi ndichifukwa choti Glycelol imapangitsa kuti firiji ikhale yocheperako, ndipo filimuyo imatha kuthyoka filimuyo ikamaponyedwa mufilimuyo. Cholinga chakuchepa kwamphamvu kwa mphamvu ya tunsile. Mphamvu yakuchulukirachulukira, kuyambira momwe ma makonzedwe amakono amakonzera makonzedwe a HPMC molecular ululu kupita ku unyolo, ndikupangitsa kulimba kwa filimuyo kukukwera pang'ono; Komabe, pakakhala gallcerol yambiri, unyolo wamatumbo amakonzedwa nthawi yomweyo monga dongosolo ladongosolo ndilokwera kuposa momwe limapangidwira mufilimuyo. Popeza zotsatira zokhumudwitsa zili powononga mphamvu ya filimu ya HPMC, kuchuluka kwa glyceron sikuyenera kukhala kochuluka.

Monga taonera pa Chithunzi 3.3 (b), ndi kuwonjezera kwa sorbitol, mtunda woponderezedwa mufilimu ya HPMC yoyamba idawonjezeka kenako ndikuchepa. Kuchuluka kwa sorbitol kunali 0,15%, mtunda woponderezedwa paphiri la HPMC adafika 45%, kenako nkongosungunuka pa filimuyo pang'onopang'ono zidachepa. Mphamvu ya anthu akufalikira mwachangu, ndikusinthasintha mozungulira 50mp ndi kuwonjezera kosalekeza kwa sorbitol. Itha kuwoneka kuti kuchuluka kwa sorfutol kuwonjezeredwa ndi 0.15%, kuponyera kwa pulasitiki ndiye yabwino kwambiri. Izi ndichifukwa choti kuwonjezera kwa mamolekyulu ang'ono a Sarbitol kumasokoneza makonzedwe okhazikika a unyolo wokulirapo, ndikupanga kusiyana pakati pa mamoleky Kuchuluka kwa sorbital kukupitilira, kutalika kothyolako kumachepetsa, chifukwa mamolekyulu ang'onoang'ono a ku Macromolecles ndi kuchepa kwa mtunda wopumira pa filimuyi.

Kuyerekezera mavuto a kupopera kwa mapira a glycerol ndi sorbitol mafilimu a HPMC, kuwonjezera 0,15% glycerol kumatha kuwonjezera ma glycerol kumawonjezera gawo lomwe limaphulika pa 50%; Ndikuwonjezera 0.15% sorbitol ikhoza kungowonjezera kuchuluka kwa mafilimu omwe akupumira mu 45%. Mphamvu ya anthu akuchepa, ndipo kuchepa kwake kunali kocheperako pomwe Glycelol adawonjezeredwa. Itha kuwoneka kuti mphamvu ya pulasitiki ya glycerol pa filimu ya HPMC ndiyabwino kuposa ya Sorbitol.

3.3.4 Zotsatira za glycerol ndi sorbitol pa zotsatsa za HPMC

(a) glycerol (b) sorbitol

Mkuyu.3.4 Zotsatira za Glycerol kapena Sorbitolum On On Chuma cha HPMC

Kuwala kopepuka ndi kuwawa ndi gawo lofunikira la kuwonekera kwa filimu ya pakompyuta. Kuwoneka ndi kumveka kwa zinthu zokhala ndi katundu kumadalira pakuwunika kopepuka komanso kuwulutsa filimu yopumira. Monga taonera Chithunzi 3.4, kuwonjezera kwa glycerol ndi sorbitol ndi sorbitol ndi sorbitol ndi sorbitol zomwe zidakhudza mafilimu a HPMC, makamaka kuwawa. Chithunzi 3.4 (a) ndi chithunzi chowonetsa zowonjezera za glycerolol kuwonjezera pa mafilimu a HPMC. Ndi kuwonjezera kwa glycerol, kupatsirana kwa mafilimu a HPMC koyamba kukuwonjezeredwa kenako ndikuchepera, kufikira phindu lalikulu kuzungulira 0,25%; Kukula kwake kumakula mwachangu kenako pang'onopang'ono. Itha kuwoneka kuchokera ku kusanthula pamwambapa komwe kuphatikizidwa kwa Glycerol ndi 0,25%, zowoneka bwino za filimuyo ndiyabwino, kotero kuchuluka kwa glycerol sikuyenera kupitirira 0,25%. Chithunzi 3.4 (b) ndi graph yowonetsa zotsatira za sorbital kuwonjezera kwa mafilimu a HPMC. Itha kuwoneka kuchokera ku chithunzi chomwe ndi kuwonjezera kwa sorbitol, kunyezimira kwa mafilimu a HPMC kumawonjezeka, kenako kumachepetsa pang'ono kenako kumawonjezeka, ndipo kuphatikizika kumawonjezeka. Kuchepa, ndipo kuwunika kowoneka bwino ndi kuwoneka kwa nsonga nthawi yomweyo pamene kuchuluka kwa sorbital kunali 0,45%. Itha kuwoneka kuti kuchuluka kwa sorbitol kuwonjezeredwa kuli pakati pa 0,35 ndi 0,45%, zopyapyala zake zili bwino. Kuyerekezera zotsatira za glycerol ndi sorbitol pazomwe mafilimu a HPMC, zitha kuwoneka kuti Sarbitol ilibe mphamvu pazinthu zamafilimu.

Nthawi zambiri, zinthu zomwe zimakhala ndi zopepuka kwambiri zimakhala ndi kutsika kotsika, komanso mosemphanitsa, koma sizomwe zimachitika nthawi zonse. Zipangizo zina zimakhala ndi zopepuka kwambiri komanso zolimbitsa thupi zapamwamba, monga mafilimu oonda ngati galasi lobzala [73]. Kanemayo adakonzekereratu kuyesa uku kumatha kusankha pulasitiki yoyenera ndi kuchuluka kwa zosowa.

3.3.5 zotsatira za glycerol ndi sorbitol pamadzi osungunuka a HPMC

(a) glycerol (b) sorbitol

Mkuyu.3.5 Zotsatira za Glycerol kapena Sorbitolumon Madzi osungunuka a HPMC

Chithunzi 3.5 chikuwonetsa zotsatira za glycerol ndi sorbitol pamadzi osungunuka a HPMC. Itha kuwoneka kuchokera pa chithunzi chomwe ndikuwonjezeka kwa pulasitiki Filimu filimuyi, ndiye kuti, kusungunuka kwamadzi kwa HPMC Filimuyo kumachepa kwambiri kwa filimu ya HPMC kuposa sorbitol. Chifukwa chomwe hydroxpyl methylcellulose uli ndi madzi abwino kususuka ndi chifukwa cha magulu ambiri a hydroxyl mu ma molekyulu ake. Kuchokera pakuwunikira kwa mawonekedwe a infrad, imatha kuwoneka kuti ndi kuwonjezera kwa glycerol ndi sorroctol kutengera kwa magulu a hpmc molekyutsi, kotero madzi osungunuka a kanema wa HPMC amatsika.

Magawo 3.4 a chaputala ichi

Kudzera mu kusanthula kwa mafilimu omwe ali pamwamba pa mafilimu a HPMC, kumatha kuwoneka kuti mapiri a Glycerol ndi sorbilol amathandizira mafilimu a HPMC ndikuwonjezera ma glangution nthawi yopuma. Kuphatikiza kwa glycerol ndi 0,15%, makinawo amakina a HPMC ndi abwino, mphamvu ya tawuni ili pafupi 60mpo, ndi mtunda wa nthawi yopuma ndi 50%; Kuphatikiza kwa glycerol ndi 0,25%, malo owoneka bwino ndi abwino. Zomwe zili ndi sorbitol ndi 0.15%, mphamvu yamphamvu ya filimu ya HPMC ili pa 55mka, ndi mtunda wa nthawi yopumira zimawonjezeka pafupifupi 45%. Pamene zomwe zili ku Sorbitol ndi 0,45%, zowoneka bwino za filimuyo ndibwino. Makina osepitsa onsewo adachepetsa kusungunuka kwamadzi a hpmc mafilimu, pomwe sorbital anali ndi mphamvu pamasamba a HPMC. Kuyerekeza zotsatirazi za mafayilo awiri pa mafilimu a HPMC akuwonetsa kuti kuwononga mafilimu a glycerol pa mafilimu a HPMC ndikwabwino kuposa a ku Sorbitol.

MUTU 4 Zotsatira zochokera kumanda pa HPMC Maphikidwe Osungunuka Masamba

4.1 Kuyamba

Hydroxypypyl methylcellulose imakhala ndi magulu ambiri a hydroxyl ndi ma hydroxyprophiroxy, motero ili ndi madzi abwino. Pepala ili limagwiritsa ntchito madzi ake bwino kusungunuka pokonzekera kanema wobiriwira komanso wosungunuka. Kutengera kugwiritsa ntchito filimu yosungunuka yamadzi, kusungunuka mwachangu kwa filimu yosungunuka madzi kumafunikira pakugwiritsa ntchito kwambiri, koma nthawi zina kuchepetsedwa kuwonongeka ndikofunikira [Chithunzi patsamba 21].

Chifukwa chake, mu mutuwu, glutaraldehyde amagwiritsidwa ntchito ngati wothandizira wosinthika wa filimu ya hydroxypyulose, ndipo pamwamba pake amalumikizana ndi filimuyo kuti muchepetse madziwo ndikuchepetsa nthawi yosungira madzi. Zotsatira za kuphatikizika kwa glutaraldeldeldeldeldeldel owonjezera pamadzi, makina, makina ndi ma vetroxypropyl mafilimu ambiri amaphunziridwa kwambiri.

4.2 Gawo loyesera

4.2.1 Zipangizo zoyesera ndi zida

Gome 4.1 Zoyeserera ndi Zojambula

4.2.2 Kukonzekera kwa centonen

1) Zolemera: Kuyeza kuchuluka kwa hydroxypropyl methylcellulose (5%) ndi njira yamagetsi;

2) Kuwonongeka: Kulemera kolemera methylcellulose kumawonjezeredwa kwa madzi okonzedwa, ndikukakamizidwanso kwa nthawi inayake, ndipo ndi glutaraldehyde yowonjezeredwa imapezeka;

3) Kupanga makanema: Jambulani filimuyo yopanga madzi mu mbale ya petri ndikuyimitsa filimuyi, ndikuumitsa filimuyo, ndikuyika mu bokosi louma kuti mubwezeretse.

4.2.3 Makhalidwe ndi Kuyeserera kwa Ntchito

4.2.3.1 infrated matchroscopy (ft-ir)

Kuyamwa infrated mafilimu a HPMC kunatsimikiziridwa kugwiritsa ntchito Nicolet 5700 Anderthomer Compatemeter yopangidwa ndi kampani ya anrmoelertric.

4.2.3.2

Kusakanikirana kwakukulu kwa X-ray (xrd) ndikuwunika kwa mkhalidwe wa crystallization ya chinthu chazomwe zimachitika. Mu pepala ili, mkhalidwe wa makristalo wa filimu yopyapyala idatsimikizika pogwiritsa ntchito arl / ntray X-ray squarcymometer yopangidwa ndi Thermo Arl of Switzerland. Miyezo Yoyenerera: Ichi ndi ray ndi chofalitsira cha nickel svase cu-kα (40 kv, 40). Jambulani ngodya kuchokera ku 0 ° mpaka 80 ° (25). Scan liwiro 6 ° / min.

4.2.3.3 Kutsimikiza kwa madzi kusungunuka: chimodzimodzi ndi 2.2.3.4

4.2.3.4 kutsimikiza kwa makina

Pogwiritsa ntchito makina oyesa a Stoneron (5943) amagetsi a Stone Eantron of Intron (Shanghai) zida zoyeserera, malinga ndi njira ya GB1302-92-92-92-92-92-92-92

4.2.3.5 kutsimikiza kwa zowoneka bwino

Pogwiritsa ntchito ma coester owoneka bwino, sankhani zitsanzo zoyesedwa ndi mawonekedwe oyera ndipo osayeza, ndikuyeza mafilimuwo filimu kutentha (25 ° C ndi 50% RH).

4.2.4 Kupanga data

Zambiri zoyesera zidakonzedwa ndi Excel ndi kuwonongeka ndi pulogalamu yoyambira.

4.3 zotsatira ndi zokambirana

4.3.1 infrated mayamwidwe a glutaralderdehyde-gload

Mkuyu.4.1 FT-IR ya HPMC ka mafilimu pansi pa glutaraldehyde

Kutumiza Mayamwidwe Sporroscopy ndi njira yamphamvu yofotokozera magulu omwe amagwira ntchito molecular kupanga mawonekedwe ndi kuzindikira magulu ogwira ntchito. Kuti mumvetsetse kusintha kwa ma hydroxypylpyl mutasinthidwe, mayeso a infrared adachitidwa pa mafilimu a HPMC isanachitike komanso itatha. Chithunzi 4.1 chikuwonetsa Spectra ya HPMC yokhala ndi kuchuluka kosiyanasiyana kwa glutaraldehyde, ndipo kuwonongeka kwa HPMC

Mayamwidwe osokoneza bongo a - ali pafupi 3418cm-1 ndi 1657cm-1. Kuyerekezera mafilimu opingasa ndi osazindikira a HPMC, kumatha kuwoneka kuti ndi kuwonjezera kwa glutaraldehyde gulu la -Oh-1 Magulu a mu HPMC Molekyu ya HPMC idachepetsedwa, yomwe idayambitsidwa ndi magulu omwe ali ndi mitanda pakati pa HPMC ndi gulu la dialdeyde pa glutaradelhhyde. Kuphatikiza apo, zinapezeka kuti kuwonjezera kwa glutaraldehyde sikunasinthe mawonekedwe amtundu uliwonse wa hpmc, kuwonetsa kuti kuwonjezera kwa glutaradehyde sikunawononge magulu a HPM yokha.

33.2 Xrd mafilimu a glutaraldeldeldelderde

Mwa kuchita za X-ray pazinthu zakuthupi komanso kusanthula njira yake yosiyanasiyana, ndi njira yofufuzira kuti ipeze chidziwitso monga kapangidwe ka atomu kapena mamolekyulu mkati mwazinthuzo. Chithunzi 4.2 akuwonetsa njira za XD Ndi kuwonjezeka kwa glutaraldelyeldelde, kulimba kwa nsonga za hpmc pafupifupi 9.5 ° zochepera 9.4 ndi 20.4 ° Kulandila kwa mtanda kumachitika pakati pa gulu la hydroxyl ndi gulu la hydroxyl pa molekyulu ya HPMC, yomwe imaletsa kusuntha kwa ma molecular molekyulu ya HPMC.

Mkuyu.4.2 xrd ya HPMC ka mafilimu pansi pa glutaralilehyde

4.3.3 Zotsatira za glutaraldehyde pamadzi osungunuka a HPMC

Mkuyu.4.3 Zotsatira za glutaraldehyde solubility ya HPMC

Kuchokera pa chithunzi 4.3 zotsatira za zowonjezera za glutaralyerdehyde pamadzi osungunuka a HPMC, zitha kuwoneka kuti ndikuwonjezeka kwa mafilimu a glutaralhyde, madzi osungira madzi a HPMC amatenga nthawi yayitali. Kulandila kwa mtanda kumachitika ndi gulu la Aldeyde pa glutaraldehyde.

4.3.4 zotsatira za glutaraldehyde zojambula zamakina a HPMC

Mkuyu.4.4 Zotsatira za Glutaraldehyde Mphamvu ndi Kuphwanya Mphamvu ya HPMC

Kuti mufufuze zotsatira za glutaraldehyde pa makina amakina a HPMC, mphamvu yotumphukira ndikuphwanya mafilimu osinthika. Mwachitsanzo, 4.4 Ndiye chithunzi cha mphamvu ya glutaraldelhyde chowonjezera cholimba chambiri ndikusintha mufilimuyo. Ndi kuwonjezeka kwa glutaralyeldeldelde, mphamvu yakuwoneka ndipo kutalika kosweka kwa mafilimu a HPMC idayamba kukonzedwa kenako ndikuchepa. zomwe zikuchitika. Popeza kulumikizana kwa glutaraldeldehyde ndi kwa olumikiza, mutatha kuwonjezera glutarardehyde molekyulu, ma glurroyde molekyumu wa HPMC yomwe imapangitsa kuti ma epmc mafilimu. Ndi kuwonjezera kosalekeza kwa glutaradelwelyohyde, kachulukidwe kakang'ono kolumikizana kumawonjezeka, komwe kumalepheretsa wachibale pakati pa ma matekyu ocheperako, omwe akuwonetsa kuti makina owonda a HPMC akutsika [76]. Kuchokera pa chithunzi 4.4, zotsatira za glutaraldehyde pa makina opanga HPMC ikuwonetsa kuti kuphatikiza kwa glutaraldeldehyde ndikwabwino, ndipo makina amakina a HPMC ndibwino.

4.3.5 Mphamvu ya glutaraldehyde pazinthu zowoneka bwino za HPMC

Kuwala kopepuka ndi kude ndi magawo awiri ofunikira kwambiri okonda mafilimu a Paketi. Chachikulu chomwe chimapangidwira, chabwino kuwonekera filimuyo; Haze, omwe amadziwikanso kuti kusokonekera, akuwonetsa kuchuluka kwa filimuyo, ndi kukula kwa filimuyi. Chithunzi 4.5 ndikuwonetsa kupindika kwa kuwonjezera kwa glutaraldehyde pa mafilimu a HPMC. Itha kuwoneka kuchokera ku chiwonetserocho kuti ndi kuwonjezeka kwa kuwonjezera kwa glutarardehyde, kumawonjezera pang'onopang'ono kumawonjezeka pang'onopang'ono, kenako kumawonjezeka mwachangu kenako kumachepetsa pang'onopang'ono; Haze adachepa koyamba kenako kenako nkukula. Kuphatikiza kwa glutaraldehyde 0,25%, kupatsirana kwa kanema kwa HPMC kunafika pamtengo wa 93%, ndipo haze adafika pamtengo wochepera 13%. Pakadali pano, magwiridwe antchito anali bwino. Cholinga chowonjezereka kwa malo owoneka bwino pakati pa glutaralyehyde ndi hydroxpyulose ya methylcellulose, ndipo yunifolomu ndi yaying'ono. Pamene wogulitsa wolumikizira mtanda ndi wowonjezera, malo olumikizirana amapezedwa, omwe akucheperachepera pakati pa mamolekyulu a dongosololi ndi ovuta, ndipo gel osavuta kuchitika. Chifukwa chake, zowoneka bwino za mafilimu a HPMC zimachepetsedwa [80].

Mkuyu.4.5 Zotsatira za Glutaraldehyde Chuma Chuma cha HPMC

4.4 Magawo a chaputala ichi

Kudzera mwa kuwunika pamwambapa, motsatira izi zakokedwa:

1) Chithunzi cha HPMC chambiri cha Gpmc

2) Ndikofunika kwambiri kuwonjezera glutaraldehyde mu 0,25% mpaka 0.44%. Pomwe kuwonjezera kuchuluka kwa glutaraldehyde ndi 0,25%, makina omwe ali ndi mphamvu zokwanira ndi zowoneka bwino za filimu ya HPMC ndibwino; Pambuyo polumikiza, madzi osungunuka a filimu ya HPMC amatenga nthawi yayitali ndipo madzi osungunuka amachepetsedwa. Kuphatikizidwa kwa glutaraldehyde ndi 0,44%, nthawi yosungunuka imafika pafupifupi 135min.

MUTU 5 Wachilengedwe Wachilengedwe HPMC Madzi osungunuka

5.1 Kuyamba

Pofuna kukulitsa kugwiritsa ntchito hydroxypropyl filimu ya chakudya, mutuwu umagwiritsa ntchito njira yopanga ma antioxidant (a Antioxidal) ma antioxidants osiyanasiyana. Kanema wa Antioxidant HPMC-soluble, kafukufuku wa antioxidant katundu, madzi kususuka, makina opanga ndi mawonedwe a filimuyo, ndikupereka maziko a pulogalamu ya chakudya.

5.2 gawo loyesa

5.2.1 Zipangizo zoyesera ndi zida zoyesera

Tabu.5.1 zoyeserera ndi zolembera

Tabu.5.2 Zoyesera

5.2.2 Kukonzekera kwa centonen

Konzani hydroxypyll nothcellulose madzi osungunuka madzi ndi mitundu yosiyanasiyana ya ma antioxidants antioxidaps, kenako onjezerani hydroxygyulose yowonjezera (0%, 0,03%, 0.05%, 0.07%, 0.09%) ya masamba amphasi a ma antioxidants njira yopanga ma cellulose, ndikupitilizabe

Kuti musakanizedwe kwathunthu, siyani kuyimilira firiji kwa mphindi 3-5 (kulongeza) kukonza njira zopangira mafilimu omwe ali ndi tizigawo tambiri tomwe timakhala ndi ma antioxidants. Pupuni mu uvuni wowuma wowuma, ndikuyiyika mu uvuni wowuma pambuyo pake mutatha kuluma. The hydroxypropyll methylcellulose madzi-soluble contagrage filimu yowonjezeredwa ndi masamba a abhixidant amatchulidwa ngati filimu ya Amob / HPMC yafupikitsa.

5.2.3 mapangidwe ndi kuyesedwa kwa magwiridwe antchito

5.2.3.1 infrated matratscopy (ft-ir)

Makonda a infratiored a hpmc mafilimu a HPMC adayesedwa mu ATR Mode pogwiritsa ntchito Nicolet 5700 tearform expretomer opangidwa ndi ma armoelectric Corports.

5.2.3.2

5.2.3.3 Kutsimikiza kwa Antioxidant katundu

Pofuna kuyeza katundu wa antioxidant a antioxidant ndi AOB / HPMC Frabing Scarting Scarting adagwiritsidwa ntchito poyesa mu mafilimu a DPPH yaulere, kuti muyenetse kukana kwa oxidation kwa mafilimu.

Kukonzekera kwa DPPH Solution: Mitundu yodulira, sungunula 2 mg ya DPPH mu 40 ml ya ethanol solventi, ndi sonicate kwa mphindi 5 kuti mupange yankho yunifolomu. Sungani mufiriji (4 ° C) kuti mugwiritse ntchito pambuyo pake.

Ponena za njira yoyesera ya Zhong Yuansheng [81], ndikusintha pang'ono, ml ya DPPH yothetsera ndikugwedeza mtengo (519nm) ndi UV Spectophotometer. ndi A0. Kuyeza kwa mtengo: onjezerani 2 ml ya DPPH yothetsera batani la HPMC yowonda yosakaniza bwino, muyeza mtengo ndi uv spectophotometer, ndi dazi zitatu zofanana ndi gulu lirilonse. Njira ya DPPH yaulere yowerengera Quarting Rection njira amatanthauza njira yotsatirayi,

Mu mawonekedwe: U ndimtundu wa zitsanzo; A0 ndiowongolera

5.2.3.4 Kutsimikiza zakumwa: zofanana ndi 2.2.3.2

5.2.3.5 kutsimikiza kwa zowoneka bwino

Malo owoneka owoneka bwino ndi zisonyezo zowoneka bwino za mafilimu a mafilimu, makamaka kuphatikizapo kuphatikizika ndi filimuyo. Kuphatikizika kwa mafilimuwa kumayesedwa pogwiritsa ntchito Conters Confent. Kuwala kowala ndi kude kwa mafilimu kudayesedwa kutentha kwa firiji (25 ° C ndi 50% rh) pa zitsanzo zoyeserera ndi mitembo yoyera ndipo palibe zopota.

5.2.6.6 Kutsimikiza kwa madzi kususuka

Dulani filimu ya 30mm × 30μm, onjezani madzi okwanira 200ml, ikani filimuyo mkati mwa madzi okwanira, ndikuyesa nthawi kuti filimuyo ithe. Ngati filimuyo imamamatira kukhoma la chomera, iyenera kuyesedwanso, ndipo zotsatira zake zimatengedwa ngati nthawi yayitali, gawo ndi mphindi.

5.2.4 Kupanga data

Zambiri zoyesera zidakonzedwa ndi Excel ndi kuwonongeka ndi pulogalamu yoyambira.

5.3 Zotsatira ndi Kusanthula

5.3.1 FT-IR

Pukuri5.1 FTIR wa HPMC ndi AOB / HPMC

Mu mamolekyu okhazikika, maatomu omwe amapanga zomangira zamankhwala kapena magulu ogwira ntchito ali munthawi zonse kugwedezeka. Pamene mamolekyu opanga ndi owala bwino, zomangira zam'madzi kapena magulu a ma mamolekyulu amatha kuyamwa manyowa, motero chidziwitso cha magulu a mankhwala kapena magwiridwe antchito molekyulu atha kupezeka. Chithunzi 5.1 chikuwonetsa FTIR Spectra ya HPMC filimu ya filimu ya AOB / HPMC. Kuchokera pa Chithunzi 5, zitha kuwoneka kuti chipongwe cha mafupa a hydroxypyllulose chimakhala ndi 2600 ~ 3700 cm-170 cm-17. Kuthamanga kwamphamvu kwambiri mu 950-1250 cm-1 makamaka makamaka dera la malo a Coketon otambasula kugwedezeka. Gulu la mayamwidwe a HPMC pafupi ndi 3418 masentimita-1 amayamba chifukwa cha kugwedezeka kwa mawu a hydroxyprophiroxy pa 1657 cm. Mayamwidwe pa 1454cm-1, 13732cm-1, 1315cm-1 ndi 945cm-1 anali ndi ma viberge, mu ndege yopanda tanthauzo la ndege za -ch 8 [83]. HPMC idasinthidwa ndi AOB. Ndi kuwonjezera kwa AOB, mawonekedwe amtundu uliwonse wa AOB / HPMC sanasunthe, kuwonetsa kuti kuwonjezera kwa AO sikuwononga magulu a HPM. Kugwedezeka kwa oh wolumikizana mu gulu la aob / HPMC pafupi ndi 3418 masentimita-1 amawonongeka chifukwa cha kusintha kwa methyl ndi methylene Comport. [Chithunzi patsamba 12]

5.3.2 Xrd

Mkuyu.5.2 xrd wa HPMC ndi AOB /

Mkuyu.5.2 xrd wa HPMC ndi AOB / HPMC

Makhalidwe a makristali a mafilimuwo adasanthuridwa ndi gawo lalikulu-lax x ray. Chithunzi 5.2 akuwonetsa njira za XDD ya mafilimu a HPMC ndi AAOB / HPMC. Itha kuwoneka kuchokera pa chithunzi chomwe kanema wa HPMC ali ndi nsonga ziwiri zosiyanasiyana (9.5 °, 20.4 °). Ndi kuwonjezera kwa AOB, nsonga yosiyanasiyana pafupifupi 9.5 ° ndi 20.4 ° imafookeza kwambiri, kuwonetsa kuti ma molekyulu a filimu ya Aob / HPMC amakonzedwa mwadongosolo. Kutha kumachepa, kuwonetsa kuti kuwonjezera kwa AB kusokoneza dongosolo la hydroxypulase ma molekyulu, ndikuchepetsa makonzedwe a hydroxygyubola.

5.3.3 Antioxidant katundu

Pofuna kuwunika zotsatira za mitundu yosiyanasiyana ya AOB / HPMC, mafilimu omwe ali ndi zowonjezera zosiyanasiyana za AOB / 0,02%, 0.09%) adasanthula, motero. Zotsatira za scavenger kuchuluka kwa maziko, zotsatira zake zikuwonetsedwa pa Chithunzi 5.3.

Mkuyu.5.3 Zotsatira za mafilimu a HPMC pansi pa AOB infor

Itha kuwoneka kuchokera pa Chithunzi 5.3 Kuti kuwonjezera kwa Antioxida sikunayendetse bwino kuchuluka kwa ma DPPM, ndiye kuti, kusokoneza kwa antih ma radicals adachulukana koyamba. Pomwe kuphatikiza kwa AOB ndi 0.03%, filimu ya AOB / HPMC ili ndi zotsatira zake zopangira ma radicals a DPPH zimafikira 89.34%, ndiye kuti, filimu ya AOB / HPMC ili ndi magwiridwe antchito abwino panthawiyi; Pamene a AAB anali 0.05% ndi 0.07%, gulu la DPHH laulere la filimu ya AOB / HPMC linali lalikulu kuposa la gulu la 0.03; Izi zitha kukhala chifukwa cha mantioxidants achilengedwe kwambiri kuphatikiza AOB adatsogolera mamolekyu a AOB ndi kufalitsa mafilimu a Antioxidant wa Antiob / HPMC. Itha kuwoneka kuti kanema wa AOB / HPMC adakonzedwa pakuyesera ali ndi ma hanti - oxidation magwiridwe antchito. Zowonjezera zikakhala 0,03%, magwiridwe antchito azomwe a AOB / HPMC ndiye wamphamvu kwambiri.

5.3.4 Kusungunuka kwamadzi

Kuchokera pa Chithunzi 5.4, zotsatira za bamboo antioxidants pamadzi osungunuka a hydroxylluphyl, zimatha kuwoneka kuti zowonjezera zosiyanasiyana za AOB zimakhudzanso mafilimu a HPMC. Pambuyo powonjezera AOB, ndikuwonjezeka kwa kuchuluka kwa AOB, nthawi yosungunuka yamadzi ya filimuyo inali yofupikitsa, kuwonetsa kuti madzi-soluble filimu ya Aob / HPMC inali bwino. Ndiye kuti, kuwonjezera kwa Ab / kukonza madzi osungunuka kwa filimuyo. Kuchokera kuwunika kwa XDD Madzi osungunuka a filimuyo.

Mkuyu.5.4 Zotsatira za AOB pamadzi osungunuka a HPMC

5.3.5 makina

Mkuyu.5.5 Zotsatira za AOB pa Mphamvu ya TESILE ndikuphwanya mafilimu a HPMC

Kugwiritsa ntchito zida zowonda kumachuluka kwambiri, ndipo mphamvu zake zimapangitsa kwambiri machitidwe a ntchito za membrane, zomwe zakhala zosangalatsa zazikulu. Chithunzi 5.5 chikuwonetsa mphamvu yakuwoneka ndi malo onyeketsa ma curves a AOB / HPMC. Itha kuwoneka kuchokera ku chithunzi kuti zowonjezera zosiyanasiyana za AOB zimabweretsa zofunikira pamakina a mafilimu. Pambuyo powonjezera AOB, ndikuwonjezera kwa AAB / AOB / HPMC. Mphamvu yakuwoneka ya kanemayo idawonetsa mtsogolo, pomwe mtunda wa nthawi yopuma unawonetsa zomwe zikuwonjezereka kenako ndikuchepetsa. Pamene ABOB ili 0.01%, kutalika kopumira pa filimuyo idafika pamtengo wokwanira 45%. Mphamvu ya AOB pa makina makina a HPMC zikuwonekera. Kuchokera kuwunika kwa Xrd, zitha kuwoneka kuti kuwonjezera kwa antioxidant AOb kumachepetsa filimu ya Aob / HPMC, potero kuchepetsa mphamvu ya a AOB / HPMC. Kukula kwa nthawi yopuma kumayamba kenako kumachepetsa, chifukwa Aob ali ndi madzi abwino amadzi ndi kuphatikizika, ndipo ndi chinthu chaching'ono cha molecular. Pa nthawi yofanana ndi hpmc, mgwirizano pakati pa mamolekyulu amafooka ndipo filimuyo imasinthidwa. Kapangidwe kakang'ono kamapangitsa kuti filimu ya AOB / HPMC yofewa yofewa komanso yokhazikika pa filimuyo ikuwonjezeka; Pamene ABOB ikupitilira kukwera, kutalika komwe kuli pa filimu ya Aob / HPMC kumachepa, chifukwa filimuyo ndiyosavuta kuthyoledwa, kotero kuti mawonekedwewo ndi osavuta pakati pa filimu ya Aob / HPMC imatsika.

5.3.6 Malo Otsatsa

Mkuyu.5.6 Zotsatira za AOB pa Chuma cha HPMC cha mafilimu a HPMC

Chithunzi 5.6 ndi graph yowonetsa kusintha kwa mafilimu a AOB / HPMC. Itha kuwoneka kuchokera ku chithunzi chomwe ndikuwonjezeka kwa kuchuluka kwa abb kuwonjezeredwa, kuphatikiza kanema wa AOB / HPMC kumatsika ndipo duze. Pamene zidziwitso za Abo sizikupitilira 0.05%, zosintha zosintha zopepuka komanso kuwuluka kwa makanema a AOB / HPMC adachedwa; Pamene Abob adapitirira 0.05%, magwiridwe osintha ang'onoang'ono ang'onoang'ono ndi Haze adathamangitsidwa. Chifukwa chake, kuchuluka kwa AOB kuwonjezeredwa sikuyenera kupitirira 0,05%.

5.4 Magawo 5.3 a chaputala ichi

Kutenga tsamba la nsungboo antioxidant (AOB) monga antioxidant ndi hydroxypropyl (hpmroxypropyl) monga matfilimu a mafilimu a antioxidar adaphatikizidwa ndi njira yopanga filimu. Kanema wa AOB / HPMC Madzi osungunuka amakonzedwa mu kuyesa uku kumakhala koyenera kwa anti-ontidation. Filimu ya AOB / HPMC yokhala ndi 0,03% io imakhala ndi pafupifupi 89% ya DPPH yaulere ya DPPH ya DPHH yaulere, ndipo mopenda bwino ndiye yabwino kwambiri, yomwe ndiyabwino kuposa iyo. Filimu ya HPMC pa 61% idasintha. Kusungunuka kwamadzi kumathandizanso kwambiri, ndipo makinawo ndi makina owoneka bwino amachepa. Kukaniza kwa oxidation kwa ob / HPMC Filimu yakulitsa ntchito pazakudya.

Mutu wa VI

1) Ndi kuwonjezeka kwa njira yothetsera HPMC yomwe ikugwira ntchito, makina amakina a filimuyo adakwera koyamba kenako ndikuchepa. Pamene njira yopanga filimu ya HPMC idayang'anizana ndi 5%, makinawo amakina a filimu ya HPMC inali yabwinoko, ndipo mphamvu yakuliya inali 116mm. Kutalika komwe nthawi yopuma ndi pafupifupi 31%; katundu wamaso ndi madzi osungunuka.

2) Ndi kuwonjezeka kwa filimuyo Kutentha, makinawo amakina a mafilimu adayamba kuwonjezeka kenako ndikuchepetsa, owoneka bwino, ndipo solication yamadzi inachepa. Kutentha kwa mafilimu ndi 50 ° C, momwe mphamvu yonse ili bwino, mphamvu yakuwala ili pafupifupi 110%, ndipo nthawi yosungunula yamadzi ili yothandiza kwambiri pa 50 ° C.

3) Kugwiritsa ntchito mapulasitiki kuti musinthe mafilimu a HPMC, ndi kuwonjezera kwa glycerol, mtunda wosweka mafilimu a HPMC adatsika kwambiri, pomwe pali mphamvu zauzimu. Kuchuluka kwa glycerone komwe kunali pakati pa 0.15% ndi 0,25%, mtunda wotamandira wa HPMC inali pafupifupi 50%, ndipo mphamvu yakuliya inali pafupifupi 60mm.

4) Ndi kuwonjezera kwa sorbitol, kutalika komwe kuli pa filimuyo kumawonjezera koyamba kenako kumachepetsa. Kuphatikiza kwa sorbitol ndi pafupifupi 0,15%, kutalika kwa nthawi yopuma kumafika 45% ndipo mphamvu ya tayi ili pafupifupi 55mm.

5) Kuphatikiza kwa mavidiyo awiri, glycerol ndi sorbitol, onse awiri anachepetsa mafuta ndi kusungunuka kwamadzi a HPMC, ndipo kuchepa sikunali kwakukulu. Kuyerekezera kuthamanga kwa mapulasitiki awiri pa mafayilo awiri pa mafayilo a HPMC, zitha kuwoneka kuti kusintha kwa pulasitili kuli bwino kuposa ku Sorbitol.

6) Kudzera mu infrated matratrocops (ftir) ndi kuwunika kwakukulu kwa X-ray. Ndi kuwonjezera kwa glutaraldeldelweldeyde, mphamvu yakuwoneka bwino komanso kukhala ndi mphamvu yopuma pa mafilimu okonzedwa okonzedwa ndikuchepa. Kuphatikiza kwa glutaraldehyde ndi 0,25%, makina opanga mafayilo a HPMC ndibwino; Pambuyo polumikiza, nthawi yosungirako madzi ipitirira nthawi yayitali, ndipo madziwo amatsika. Kuphatikiza kwa glutaraldehyde ndi 0,44%, nthawi yosungirako madzi imafika 135min.

7. Filimu ya AOB / HPMC yokhala ndi 0.03% AOB yowonjezera 0,03% AOB DRICH Mpukutu wa 89%, yomwe ndi 61% kuposa afilimu ya HPMC yopanda iob. Kusungunuka kwamadzi kumathandizanso kwambiri, ndipo makinawo ndi makina owoneka bwino amachepa. Pomwe chowonjezera cha 0.03% azob, anti-oblidation mphamvu ya filimuyo ndiyabwino, ndipo kusintha kwa filimu ya Abnid

Post Nthawi: Sep-29-2022

Kukonzekera ndi katundu wa hydroxypropyll methylcellulose