Njira yosavuta ya hydroxypypyl methylcellulose (hpmc)

Hydroxypropyl methylcellulose (hpmc) ndi malo opangidwa ndi polymer omwe amagwiritsidwa ntchito kwambiri mu mankhwala, chakudya, ntchito, zodzola komanso minda ina. Ili ndi madzi abwino kwambiri amadzi, katundu wa Colloidal komanso kukhazikika, motero ali ndi ntchito zofunikira m'mafakitale osiyanasiyana. Pofuna kuonetsetsa kuti ndi ungwiro wake, kuzindikiritsidwa koyenera ndikofunikira. Zotsatirazi ndi njira zingapo zodziwika bwino za hydroxypyllllulose (hpmc), zophimba zina monga mawonekedwe, kusungunuka, zoperewera zamankhwala.

1. Maonekedwe Abwino
Nthawi zambiri hpmc nthawi zambiri zimakhala zoyera kapena zoyera, fungo labwino, zopanda mafuta komanso zopanda pake. Poona mawonekedwe ake, mutha kuweruza mopitirira muyeso kaya ndi koyera hpmc. Kusintha kulikonse kapena kukhalapo kwa zosafunikira kungasonyeze kuti zitsanzo zimadetsa kapena kuipitsidwa.

2. Chizindikiritso chosungunuka
HPMC ili ndi zosungunuka bwino, makamaka m'madzi. Ikani pang'ono m'madzi ndikusunthira pang'ono. Ngati ikhoza kusungunuka mwachangu ndikupanga yankho la colloml la collonel, zikutanthauza kuti samproxypropyll methylcelulose. Kuthamanga kwa kusungunuka ndikuwoneka kuti yankho la yankho litha kukhala yokhudzana ndi maselo olemera a hpmc ndi zomwe zili hydroxypropyl ndi methyl Magulu.

Nthawi yomweyo, kusungunuka kwa HPMC ku Ordic kumatha kugwiritsidwanso ntchito ngati muyeso wa chizindikiritso. HPMC imasungunuka m'malo okhazikika (monga acetone, ethanol, etc.), koma zopanda nzeru mu mafuta onenepa. Khalidwe ili lingavomerezenso poyesa kusungunuka kwake m'malo oyenera.

3..
Yoperekedwa Spectroscopy (IR) ndi chida chozindikiritsa cholondola chomwe chingathandize kutsimikizira kapangidwe ka HPMC. Chinthu chachikulu cha HPMC ndi kuphatikiza magulu monga methyl (-ch3) ndi hydroxypropyl (-ch2ch (oh) ch3). Kukhalapo kwa maguluwa kumatha kutsimikiziridwa ndi mayamwidwe a IR Spectrum.

Maonekedwe ophatikizika a HPMC's IR Spectrum amaphatikiza:

2920 cm-1 (Ch ch chkutch yotambalala)

1450 masentimita-1 (Ch kugwedezeka)

1100-1200 cm-1 (kugwedezeka kwa COC)

3400 cm-1 (outch yotambasula, mtengo wamtengo wapatali ungasinthe chifukwa cha kupezeka kwa madzi)

Poyerekeza ir Ir Spectrum ya HPMC Standard HPMC, imatha kufananizidwa ndi mawonekedwe a zitsanzo zosadziwika kuti zitsimikizire chitsanzo cha zitsanzo.

4. Chidziwitso cha Mankhwala
HPMC, ngati ether compound, ili ndi mankhwala ena ndipo amatha kuzindikirika ndi zotsatirazi zomwe zimachitika mosavuta mankhwala.

(1) Kuchita mwamphamvu mu acidic mikhalidwe:
Sungunulani pang'ono mu madzi a hpmc m'madzi, onjezani kuchepetsa hydrochloric acid, ndi kutentha. Ngati colloidal chinthu chimapezeka mu yankho, zikutanthauza kuti ili ndi HPMC. Izi zitha kuzindikirika ndi kukhazikika kwa ma hydroxypyll ndi methyl m'magulu acidic.

. Sizovuta kupasuka pansi pa mikhalidwe ya alkalinine (monga sodium hydroxide Solution), zomwe zimakhudzana ndi hydrophilicity yake ndi hydrogel katundu. Ngati yankho ndi Turbid kapena wokhazikika, zikutanthauza kuti hpmc ilipo.

5. Kuzindikiritsa njira ya Visctony HPMC ndi chinthu chomwe chili ndi mawonekedwe a ma victoni, kotero titha kuzindikiridwa ndi mawonekedwe ake mu njira yothetsera matenda am'madzi. Nthawi zambiri, ma hpmc apanga colloidal chinthu cha ma viscess ndi ma viwa ena atatha kusungunuka m'madzi, ndipo ma utoto amawonjezeka ndi kuchuluka kwa zolemera zake.

Kuti muyeze mafayilo, thupi la HPMC yankho limatha kuyesedwa pogwiritsa ntchito ufa wozungulira kapena wotchire wagalasi. Malinga ndi kuchuluka kwa zolemera za HPMC ndi kukhazikika kwa njirayi, mafayilo ake akhoza kuwerengedwa. Ngati mafayilo a sampuli ndi yotsika kwambiri kuposa momwe imakhalira ndi HPMC yothekera, zitha kuwonetsa kuti zosakaniza zake ndizosayera kapena kunenepa.

6. Point Pofting / Dongosolo Loyesa HPMC, ngati kulemera kwambiri, nthawi zambiri sikukhala ndi malo osinthika, koma awonetsa kufewetsa kapena kuwonongeka potentha. Pamene hpmc imatenthedwa, kusintha kwake m'njira zosiyanasiyana kumatha kuonedwa. Nthawi zambiri, hpmc iyamba kuwola pa 180-200 ℃, kumasula zinthu zina zosasunthika (monga madzi ndi okhazikika). Kusintha kwa kuwonongeka kumatha kutsimikizira ngati Sampuliyo ndi yoyera ya HPMC.

7. Solubility ndi njira yovuta
Njira yothetsera vutoli idapangidwa pambuyo pa HPMC imasungunuka nthawi zambiri imakhala ndi mavuto otsika. Kusamvana kwa HPMC kumatha kuyesedwa pogwiritsa ntchito tensiometer kapena njira yoledzera. Ngati ikugwirizana ndi zovuta za muyezo njira, zikutanthauza kuti chitsanzo ndi HPMC.

Zomwe zili pamwambazi zimayambitsa njira zingapo zofala komanso zosavuta zodziwitsira hydroxypropyl methylcellulose (hpmc). Njirazi zimadziwika ndi HPMC kuchokera ku makondo angapo monga maonekedwe, kusungunuka, kuperewera kwa mankhwala, kutsimikizika kwa sample, kutsimikizika kuti agwiritsidwe ntchito m'mafakitale osiyanasiyana.