Hydroxypylmmyl methylcellulose (hpmc, hydroxypropyl methylcellulose) ndi polymer cource yomwe imagwiritsidwa ntchito pomanga, mankhwala, chakudya ndi minda ina. Idakopa chidwi kwambiri chifukwa cha madzi ake apadera. Kusungidwa kwamadzi kumakhudza magwiridwe antchito ndi ntchito yake, kotero ndikofunikira kuti mufufuze molondola magwiridwe antchito a madzi a HPMC.
1. Kapangidwe ka mankhwala ndi kulemera kwa ma celecular
1.1 kapangidwe ka mankhwala
HPMC ndi polymer yosinthidwa ndi methylcellulose (MC) gawo ndi hydroxypropyl (HP). Magulu a hydrophilic magulu (monga ma hydroxyl ndi methoxy magulu) ndi magulu a hydrophobic (monga magulu a mageloxy) muzosasinthika. HPMC yokhala ndi madigirii osiyanasiyana azolowa m'mitundu yake idzakhala ndi kusiyana kwakukulu m'madzi ake osasungidwa chifukwa cha kuchuluka kosiyana ndi kugawa kwa ma hydrophilic. Mulingo wapamwamba wa hydroxypropyll imathandizira kukonza magwiridwe antchito a HPMC.
Kulemera kwa 1.2
Kulemera kwa maselo ndi chinthu china chofunikira chomwe chikukhudza magwiridwe antchito a HPMC. Nthawi zambiri, olankhula moleclar ndi olemera kwambiri pa netiweki yamphamvu mu yankho chifukwa cha chenichere cha molecular mole, chomwe chimatha kugwira ndikusunga chinyezi. Komabe, kulemera kwambiri kumatha kubweretsa kusautsika kosauka, komwe sikuthandizira kugwiritsa ntchito.
2. Kusungunuka
Kusungunuka kwa HPMC m'madzi kumakhudzanso madzi ake. HPMC imawonetsa kusandulika bwino m'madzi ozizira, ndikupanga njira yowonekera kapena pang'ono ya Conloidal. Kusungunuka kwake kumakhudzidwa ndi kutentha, ph ndi elec electrolyte ndende.
Kutentha: HPMC ili ndi kusungunuka bwino pamiyeso yotsika, koma ng'alu ingachitike kutentha kwambiri, kuchepetsa magwiridwe antchito a madzi.
Mtengo wa PH: HPMC ili ndi solubility wapamwamba kwambiri popanda kulowerera ndale kapena kufooka kwa alkaline. Pansi pa acidic kwambiri kapena alkaline, kusungunuka kwake ndi kusungidwa kwamadzi kumakhudzidwa.
Electrolyte ndende: Evertolyte ndende imafooketsa magwiridwe antchito a HPMC chifukwa ma electrolyte amatha kulumikizana ndi ma hydrophilic magulu a HPMC moleky.
3.. Sinthani Masulidwe
Njira ya kusintha ndi chizindikiro chofunikira kuyeza magwiridwe antchito a madzi a HPMC. Makutu a HPMC Sotion amatsimikiziridwa ndi kulemera kwake komanso kukhazikika kwa nkhawa. Kuthetsa kwa HPMC HPMC kumatha kupanga network yokhazikika ya hyddiction ndikuthandizira kusungidwa kwamadzi. Komabe.
4. Zotsatira za zowonjezera
Otsatsa: monga cellulose zochokera kwa cellulose ndi chingamu, chimatha kukonza madzi osungira kwa HPMC polimbana ndi mawonekedwe a hydration network.
Mapulasitiki: monga glycerol ndi ethylene glycol, imatha kuwonjezera kusinthasintha ndi kuwongolera njira za HPMC ndikuthandizira kukonza madzi osungira.
Mtumiki wolumikizirana: monga borate, zomwe zimawonjezera mphamvu ya HPMC kudzera pamtunda wolumikizirana ndikuwongolera mphamvu yake yosungitsa madzi.
5. Njira Yokonzekera
Njira Yankho: HPMC imasungunuka m'madzi ndikukonzekera potenthetsa, kutuluka, kuwuma ndi njira zina. Kusunga kwamadzi Kugwirira ntchito kumagwirizana kwambiri ndi kutentha kwa kutentha ndi kusintha kwakukulu pakutha.
Njira Yowuma: Kuphatikizanso njira yowuma ufa, njira yopumira, etc., yomwe imawonjezera magwiridwe antchito a HPMC kudzera kusakanikirana kwakuthupi kapena kusinthidwa kwamankhwala. Madzi ake akhudzidwa ndi zinthu monga kutentha komanso kusakanikirana nthawi.
6. Mikhalidwe Yachilengedwe
Zinthu zachilengedwe za HPMC pa ntchito, monga kutentha, chinyezi, ndi zina zambiri, zimakhudzanso magwiridwe ake.
Kutentha kwambiri madera, hpmc kumatha kuwonongeka kapena kugwedeza, kuchepetsa mphamvu yake yosungitsa madzi.
Chinyezi: Pokhala ndi chinyezi kwambiri, hpmc chitha bwino kuchotsa chinyezi komanso magwiridwe antchito am'madzi, koma chinyezi chambiri chimatha kuyambitsa kuchuluka kwakukulu kapena kuphatikizika kwa malonda.
Kuwala kwa Ultraviolet: Kuwonekera kwa nthawi yayitali ku kuwala kwa ultraviolet kungayambitse hpmc kuti muchepetse ndikuchepetsa malire ake osasunga madzi.
7. Magawo a mapulogalamu
Minda yosiyanasiyana yofunsira imakhala ndi zofunikira zosiyanasiyana pakusunga kwamadzi kwa HPMC. Pomanga zida zomangira, HPMC imagwiritsidwa ntchito ngati mankhwala osungira matope a simenti, ndipo ntchito yake yosungira madzi imakhudzanso kugwirira ntchito komanso kusokonekera kwa matope. Mu gawo la pharmaceutical, hpmc nthawi zambiri limagwiritsidwa ntchito ngati piritsi lokutidwa ndi ma piritsi, ndipo madzi ake osungitsa madzi amakhudza kuchuluka kwa mapiritsi komanso kumasula mapiritsi. Mu gawo la chakudya, hpmc imagwiritsidwa ntchito ngati thicker ndi staterizer, ndipo maziko ake osungira amakhudza kukoma ndi mawonekedwe a malonda.
8. Njira zoyeserera
Kuyesa kwamadzi: sinthani magwiridwe antchito am'madzi a HPMC pakuyeza madzi olemera mkati mwa nthawi yayitali.
Kuchepetsa Madzi Kuchuluka kwa madzi: Funsani madzi osungirako za HPMC pakuyeta kutaya kwake kwamadzi mu kutentha ndi chinyezi.
Kukhazikika kwa madzi: ntchito zogwirizira madzi zimawunikidwa mwa kusanthula mphamvu zake kuti zithetse madzi pansi pa misampha yosiyanasiyana.
Kusunga kwamadzi kwa HPMC kumatsimikiziridwa ndi zinthu zosiyanasiyana monga kapangidwe kake, kunenepa kwambiri, kusinthasintha kwa zowonjezera, kusintha kwa zowonjezera, minda yokonzekera. Pamapulogalamu othandiza, zinthu izi zikufunika kuganiziridwa momveka bwino kuti zitheke ndi njira ya HPMC kuti ikwaniritse madzi abwino. Kudzera mu formula yovomerezeka ndi njira yowongolera, magwiridwe antchito a madzi ku HPMC akhoza kugwiritsa ntchito bwino komanso mtundu wa zomwe zachitikazo zitha kusintha.
Post Nthawi: Feb-17-2025