Kodi chitukuko cha chitukuko cha mankhwala am'mimba am'madzi ndi chiani?

1) Kugwiritsa ntchito gawo lalikulu la ma cellulose ether ether

Pamunda wamankhwala, ma cellulose ndi ofunika kwambiri ophatikizika, omwe amagwiritsidwa ntchito kwambiri m'minda ya piritsi yokutidwa, kuyimitsa wothandizira, kapisozi kachulukidwe ka masamba, kukonzekera kokhazikika komanso koyenera ndi magawo ena azachipatala. Pakati pawo, cellulose ether yomwe imagwiritsidwa ntchito pokonzekera kuchuluka kwa mankhwala osokoneza bongo (makamaka ma cellulose a ether ortud kukonzekera) ndi imodzi mwazinthu zamagetsi zomwe zimakhala ndi zovuta kwambiri komanso mtengo wapamwamba kwambiri, ndipo mtengo wamsika ndiwokwera. Cellulose embi monga hpmc, Mc, HPC, ndi EC imaphatikizidwa mu gawo 2020 lotchedwa "pharmacopoeia" ndi "USP 35".

2) Kupanga chitukuko cha ma cellulose embi

Chitukuko chofulumira komanso chokwera kwambiri pamsika wopezeka pagawo limayendetsa kukula kwa kuchuluka kwa ma cellucese ethelu

Zowonjezera za mankhwala ndizosangalatsa komanso zowonjezera zomwe zimagwiritsidwa ntchito popanga mankhwala ndi kapangidwe ka mankhwala. Pankhani ya kukonzekera kwa mankhwala opanga mankhwala nthawi zambiri kumakhala kopitilira 80%. Ngakhale zowonjezera zazopezeka sizili gawo lalikulu la mankhwala osokoneza bongo, omwe ali ndi ntchito zofunika kwambiri, ndikugwira ntchito ngati kusungunuka, kusinthana kwapang'onopang'ono, kuwongolera ndi mtundu wa kukonzekera. chofunikira kwambiri. M'zaka zaposachedwa, kuchuluka kwa malonda opezeka pamtunda wayamba pang'onopang'ono ndipo akukula kwambiri.

Kumbali imodzi, monga momwe ndalama zachuma zimakhalira, kuchuluka kwa anthu omwe akukalamba kukupitilizabe kukulitsa mankhwala osokoneza bongo komanso kuchuluka kwa mankhwala osokoneza bongo, kusintha kwa msika waku China kumawonetsa zomwe zili mmwamba. Malinga ndi ziwerengero zochokera ku Asiha Resurery Institute, msika wa China wa China mu 2021 ufika 1,817.6 biliyoni Yuan. Poyerekeza ndi kukula kwa msika wa 1,430.4 biliyoni Yuan mu 2017, kuchuluka kwa kuchuluka kwapachaka kudzakhala 6.17%. Akuyerekeza kuti kukula kwa msika wamankhwala a China mu 2022 kudzawonjezeka mpaka 1,853.9 biliyoni Yuan. Kukula mwachangu kwa malonda a dziko langa kumayendetsa mwachindunji kukula kwa zomwe zimachitika kwa okwera mankhwala.

Kumbali inayo, ndondomeko yam'nyumba imasintha kuyendetsa kwa mafakitale ophatikizira a mankhwalawo. Pakadali pano, msika wapadziko lonse lapansi wopatsa mphamvu umagawidwa ku Europe ndi North America. Msika wapanyumba wopindulitsa wa mankhwala adayambanso mochedwa, ndipo njira zoyenera sizili bwino. Gawo la phindu la kupanga ndi lotsika. Kukhazikitsa kwa mfundo zoyenera monga kuwunika kwanyumba ndi mankhwala osokoneza bongo komanso kuvomerezedwa kumalimbikitsa kusintha kwa zofunikira zamankhwala opanga mankhwala, chifukwa chofunafuna mtengo wapamwamba kwambiri komanso wokhazikika.

Malinga ndi kuneneratu kwa A SIANA Kufufuza Institute, gawo la dziko langa la mankhwala ogulitsa zinthu pafupifupi 20% kuchokera pa 2020. Monga 2025, ndipo akuyembekezeka kuchita masewera olimbitsa thupi a 10025.

① Gawo la garricecical gpmc ndiye chinthu chachikulu chopangira mapulogalamu a HPMC, ndipo njira yamsika ili ndi mwayi wabwino

PERRMUUTICARICE-GPME HPMC ndiye chinthu chachikulu chopangira mapulogalamu a HPMC. Makapisozi a HPMC amatulutsa amakhala ndi zabwino zotetezeka komanso zaukhondo, kugwirira ntchito kwakukulu, kulibe chiopsezo cholumikizirana cholumikizira, komanso kukhazikika kwambiri. Pakadali pano, makapisozi a HPMC amagwiritsidwa ntchito makamaka pazambiri zaumoyo, ndipo zomwe zimafunikira zimachitika ku United States, Europe, Japan ndi mayiko ena otukuka okhala ndi misika yazachuma kwambiri. Makampani ogulitsa azaumoyo padziko lonse lapansi akuwonetsa kukula kokhazikika. Malinga ndi ziwerengero za Euromonalonator, pofika 2021, makampani ogulitsa padziko lonse lapansi amakhala ofunika kuti US $ 273.242 biliyoni.

Makapisozi a masamba ndi obiriwira, achilengedwe, komanso otetezeka kwambiri. Amakumana ndi zomwe amakonda zamankhwala, zamasamba, ndi okhulupirira ena achipembedzo. Amatha kulowa mwadzidzidzi m'maiko omwe ali ndi kuchuluka kwakukulu kwa anthu aku North America, Europe, ndi West Asia. Malinga ndi ziwerengero kuchokera ku kafukufuku wa dziko lonse lapansi grade hpmc m'misika yapakhomo ndi yakunja.

② Mapulogalamu a garmaceutical cellulose ether ether ndi imodzi mwazinthu zopangira zazikulu zopangidwa ndi mapangidwe omasulira a mankhwala

Kutulutsa kokhazikika komanso koyenera kumagwiritsidwa ntchito kwambiri popanga mankhwala m'mayiko otukuka. Kukonzekera kokhazikika kumatha kuzindikira momwe amasulidwe pang'onopang'ono kwa mankhwala osokoneza bongo, pomwe oyenera kulamulidwa kumatha kuzindikira zotsatira zakuwongolera nthawi yomasulira ndi mankhwala osokoneza bongo. Kukonzedwa ndi kuwongolera kumasulidwa kumatha kusunga magazi kusinthidwe kokhazikika, chotsani zoopsa ndi zoyipa zomwe zimachitika chifukwa cha kukonzekera kwa magazi ndi mankhwala a mankhwala, ndikuchepetsa mphamvu ya mankhwala. Onjezani mtengo wowonjezeredwa wa mankhwala ndi malire akulu. Pulogalamu ya mankhwala am'mimba cellulose ether ndi imodzi mwazinthu zopangira kiyi yopanga magetsi omasulira komanso olamulidwa. Kwa nthawi yayitali, ukadaulo wopanga wa HPMC (CR kalasi) yokonzekera kumasulidwa kwakhala m'manja mwa makampani ochepa otchuka padziko lonse lapansi. Mtengo wokwera waletsa kukwezedwa ndikugwiritsira ntchito malonda ndi kukweza kwa malonda a dziko langa. Kukula kwa cellulose etrase kuti utuluke pang'onopang'ono ndi wowongolera kuti ufulumize kukweza kwa malonda a dziko langa ndipo ndilofunika kwambiri kuteteza miyoyo ndi thanzi la anthu komanso thanzi.

Malinga ndi kuwongolera kutsogolera kwa mafakitale (2019) Prezirocecial cellulose ether ether ndi hpmc pokonzekera mankhwala a mankhwala ndi zokolola zatsopano, makapisozi a masamba ali pamzere ndi chitukuko cha dziko la mafakitale.