Kodi pali kusiyana kotani pakati pa HPMC ndi MC mu mankhwala ogulitsa mankhwala?

Hydroxypropyll methylcellulose (hpmc) ndi methyllulose (MC) ndi ma cellulose omwe amagwiritsidwa ntchito kwambiri pakugwiritsa ntchito mankhwala omwe amagwiritsidwa ntchito kudera lawo. Ngakhale ali ofanana, ali ndi kusiyana kosiyana ndi kapangidwe kake, katundu, ntchito zomwe zimawapangitsa kukhala oyenera pazifukwa zosiyanasiyana zamakampani opanga mankhwala.

Kuphatikizika kwa mankhwala ndi kapangidwe kake
Hydroxypropyl methylcellulose (hpmc):

Hpmc ndi etherlose yosinthika yamankhwala. Zimachokera ku celluluse pochiza ndi methyl chloride ndi ma propylex oxide, omwe amayambitsa metoxyppyupyl (-ch2chohch3) magulu m'mphepete mwa nyanja. Mulingo wa zolowa m'malo (DS) ndi molar Exffictutit (MS) kudziwa kuchuluka kwa maguluwa. DS imayimira chiwerengero cha ma hydroxyl omwe adalowa m'malo mwa anilroglucose pa unit, pomwe MS ikuwonetsa kuchuluka kwa ma hydroxypyl omwe amaphatikizidwa.

Methylcellulose (MC):

MC ndi mpulogalamu wina wa cellulose, koma imasinthidwa mofafanizidwa ndi HPMC. Imapangidwa ndi kuchiritsa cellulose ndi methyl chloride, chifukwa cholowa m'malo a ma hydroxyl ndi magulu a methoxy. Kusintha kumeneku kumakwaniritsidwa ndi digiri ya kulowetsedwa (DS), komwe, kwa MC, nthawi zambiri kumachokera ku 1.3 mpaka 2.6. Kusowa kwa magulu a hydroxypyl mu MC kumasiyanitsa ndi HPMC.

Katundu wathupi
Solity ndi Getustion:

HPMC imasungunuka mu madzi ozizira komanso otentha, ndikupanga yankho la colloidal. Atatenthetsa, HPMC imapezeka kwambiri kuphedwa, kutanthauza kuti gel osakaniza mukamatenthedwa ndikubwezeretsa yankho la kuzizira. Katunduyu ndi wothandiza kwambiri pakuwongolera mankhwala osokoneza bongo komanso monga ma viscence owonjezera pamankhwala am'madzi.

MC, kumbali inayo, amasungunuka m'madzi ozizira koma osasunthika m'madzi otentha. Zimakhalanso zophukira; Komabe, kutentha kwake kwa miyala nthawi zambiri kumakhala kotsika kuposa ku HPMC. Khalidwe ili limapangitsa MC zoyenera mafoni omwe kutentha kwa ma bilation kumakhala kopindulitsa.

Makulidwe:

Onse a HPMC ndi MC imatha kuwonjezera mafayilo osintha, koma hpmc nthawi zambiri amapereka ma viscosies ambiri chifukwa cha mitundu yake yosiyanasiyana. Kusiyanaku kumapereka kumathandizira kuwongolera molondola momwe mungagwiritsire ntchito mbiri yapadera.

Magwiridwe antchito mu mankhwala
Hpmc:

Makina olamulidwa ndi matrix:
HPMC imagwiritsidwa ntchito kwambiri pakuwongolera matrix kumasula matrix. Kutha kwake kutupa ndi kupanga gel osanjikizana ndi zamagetsi pamagetsi kumathandiza kuti azigwiritsa ntchito mankhwala omasulira mankhwala. Wosanjikiza gel osanjikiza umakhala chotchinga, ndikusintha kusiyanasiyana kwa mankhwalawa ndi kufalitsa kumasulidwa kwake.

Kuchulukitsa makanema:
Chifukwa cha zinthu zake zabwino kwambiri zamakanema, hpmc imagwiritsidwa ntchito kwambiri pokutidwa ndi mapiritsi ndi pellets. Imapereka chotchinga chotetezera chinyezi, mpweya, ndi kuwala, kulimbitsa bata ndi alumali moyo wa malonda. Kuphatikiza apo, zokutira za HPMC zitha kugwiritsidwa ntchito pokoma masking komanso kusintha mawonekedwe a mapiritsi.

Baner mu piritsi:
HPMC imagwiritsidwanso ntchito ngati chomangira mu zonyowa zamagetsi. Imatsimikizira mphamvu yamakina mapiritsi, kuwongolera tinthu tating'onoting'ono tinthu tating'onoting'ono.

Kuyimitsa ndi Kukula Kwa Working:
Mu madzi amadzimadzi, hpmc amagwira ntchito ngati kuyimitsa ndi kukula. Makulidwe ake okwera amathandizira kuti agawidwe ka yunifolomu yoyimitsidwa ndikusinthasinthasintha kwa mawonekedwe.

Mc:

Tsambali:
MC imagwiritsidwa ntchito ngati chomangira mu piritsi. Imakhala yolimbikitsa katundu ndi mphamvu yamakina pa mapiritsi, iwonetse kukhulupirika kwawo pakusamalira ndi kusungira.

Disvinrantrant:
Nthawi zina, mapiritsi omwe amatha kugwiritsa ntchito mapiritsi am'madzi, othandizira kuti athetse zidutswa zocheperako pakukumana ndi zamadzimadzi, potero potsogolera mankhwala.

Mapangidwe omasulidwa:
Ngakhale osafala kwambiri kuposa HPMC, MC itha kugwiritsidwa ntchito pakutulutsa kotulutsidwa. Katundu wake wa thermogelation amatha kugwiriridwa ntchito kuti ayang'anire mbiri ya mankhwala.

Kukula ndi Kukhazikika:
MC imagwiritsidwa ntchito ngati wothandizila komanso wokhazikika mu madzi osiyanasiyana ndi miyeso yolimba. Kutha kwake kukuwonjezera ma Isccon kumathandizira kusunthika ndi kukhazikika kwa malonda.

Ntchito Zapadera pa Masewera
Ntchito za HPMC:

Kukonzekera kwa ophthalmic:
HPMC imagwiritsidwa ntchito nthawi zambiri mu ophthalmic mayankho ndi ma gels chifukwa chopachika komanso ma visaelastic. Imapereka chisungu komanso kusunga nthawi yolumikizana ndi mankhwala ndi ocular.

Njira Zothandizira Kutumiza:
HPMC imagwiritsidwa ntchito poyendetsa matembenuzidwe pomwe luso lake lopanga mafilimu limathandizira kupanga matrix olamulidwa kuti aperekedwe mankhwala pakhungu kudzera pakhungu.

Mitundu Yoyipa:
Katundu wa mucohediaves a hpmc amapangitsa kuti ikhale yoyenera ku Bucccal, minda yamanjenje, ndi juginal yotumizira mankhwala osokoneza bongo, zimathandizira nthawi yokhazikika ya kapangidwe kake kameneka.

Mapulogalamu a MC:

Mapangidwe apamwamba:
MC imagwiritsidwa ntchito kwambiri mafuta, ma gels, ndi mafuta omwe zimachitika monga momwe zimakhalira ndikukula ndi kukhazikitsa, kukonza kufalikira komanso kusasinthika kwa malonda.

Chakudya ndi Nthalira:
Zoposa zam'materiziriziridwe, MC imapeza mapulogalamu mu chakudya ndi mankhwala a mtedza ngati thiccener, emulsifier, ndi kukhazikika, zomwe zimathandizira kapangidwe ka zinthu zosiyanasiyana.

Mwachidule, hpmc ndi MC ndi onse ofunikira omwe amapezeka ndi zikhalidwe zosiyanasiyana zomwe zimapangitsa kuti azigwiritsa ntchito njira zosiyanasiyana zamankhwala. HPMC, ndi kusungunuka kwake kachiwiri m'madzi otentha komanso ozizira, mavioni apamwamba kwambiri, komanso kuthekera kwa makanema, kumakondedwa makamaka chifukwa cha kumasulidwa kwa mafilimu, ndipo kukonzekera kwa Ophthalhami. MC, pomwe yosavuta kuphatikizira, imapereka zabwino zapadera m'madzi ozizira ozizira komanso kutentha kwamphamvu, kumapangitsa kuti zikhale zothandiza monga chogwirira, kusazindikira, komanso kukula kwa ntchito. Kuzindikira kusiyana kwa nyumba zawo zamankhwala, zinthu zakuthupi, ndi magwiridwe antchito amalola kuti opanga ma cellulose athe kukwaniritsa zosowa zapadera za mankhwala.