Zosangalatsa za mankhwala ndizosangalatsa komanso zophatikizira zomwe zimagwiritsidwa ntchito popanga mankhwala osokoneza bongo, ndipo ndi gawo lofunikira pakukonzekera kwa mankhwala. Cellulose ether monga zochokera ku zinthu zachilengedwe zakuthupi, zili ndi mawonekedwe a biolimose cellouse, ma hydroxypyl cellose, ethel ether ali ndi mtengo wofunikira mu Zosangalatsa za mankhwala. Pakadali pano, zinthu zambiri zam'madzi zam'madzi zimagwiritsidwa ntchito makamaka pamafashoni otsika, mtengo womwewo sukwera, makampaniwo ndiofunikira kusintha kwa zinthu.
Msika wa Prermaceustical
Zosangalatsa za mankhwala zimatenga gawo lofunikira mu chitukuko ndi kupanga zokonzekera mankhwala. Mwachitsanzo, pakukonzekera, ma ether a cellulose ndi zida zina za polymer monga zothandizira mankhwala opangira mankhwala omwe amagwiritsidwa ntchito molimbika, makapiketi osiyanasiyana, amasulidwa kukongoletsa, amasulidwa kukonzekera kwamadzimadzi. M'dongosolo lino, cellulose ether ndi ma polima ena nthawi zambiri amagwiritsidwa ntchito ngati mankhwala osokoneza bongo kuti ayang'anire kumasulidwa kwa mankhwala osokoneza bongo m'thupi la munthu, ndiye kuti, amafunikira kumasulidwa pang'onopang'ono mthupi mwa nthawi ina kuti akwaniritse cholinga chothandizira chithandizo chothandiza.
Malinga ndi ziwerengero za ziwerengero za ZHyaan ndikufufuza, China zalembedwa zamitundu pafupifupi 500, koma mitundu yoposa 1500), mtundu wa China umakhala waukulu. Zimamveka kuti zothandizira khumi zopitilira khumi mu kumsika wina ndi mankhwala a mankhwala a gelatin captulupyl, 1, 2-ma procrystall celloluse, hpc, lactose.
Zisanu ndi chimodzimitundu yacellulose ethermuZowonjezera za mankhwala
Ether cellulose ether ndi alkali cellulose ndikumuyeza munthawi zina zomwe zimachitika kuti atulutse ma cellulose angapo. Cellulose ether imagwiritsidwa ntchito kwambiri ku mafuta, zomangira, zokutira, chakudya, mankhwala ndi minda ya tsiku ndi tsiku, malo ogulitsira opangira mankhwala mosiyanasiyana. Chifukwa cha zofuna zabwino, kupanga kwa ma cellufuucal ethel ether ndizovuta kwambiri, zitha kunenedwanso kuti mtundu wa magawo a garriceceutical umayimira mphamvu ya ethel ether. Cellulose ether nthawi zambiri imagwiritsidwa ntchito ngati blocker, mafupa ndi viscosifier kuti iwonjezere, zopangidwa ndi ma skeleton-amasungunula zida, zosungunulira micCobsule-zotulutsidwa-mankhwala othandizira.
Sodium carboxymethyl cellulose
Sodium Carboxymethmethmethmethmethyl cellulose (cmc-na) ndi mtengo waukulu kwambiri ndi mitundu ya alfali, ya chloroceic asidi. CMC-NA ndi mtundu womwe umagwiritsidwa ntchito kwambiri wamankhwala ophatikizika, omwe nthawi zambiri amagwiritsidwa ntchito ngati zomatira kukonzekera molimba ndi zotupa komanso zopukutira matrix opanga madzi. Pang'onopang'ono (olamulidwa) kumasulidwa, nthawi zambiri imagwiritsidwa ntchito ngati zofunikira zam'manja za mankhwala pang'onopang'ono ndi mapiritsi a chimango kuti atulutsidwe pang'onopang'ono.
Kuphatikiza pa sodium carboxymethyl cellulose monga mankhwala opangira mankhwala, opingasa ma sodium carboxyl amathanso kugwiritsidwanso ntchito ngati mankhwala othandizira. Chuma chopingasa carboxymethmethmethmethyl cellulose (ccmc-na) ndi madzi oyeretsedwa a Carboxymethyl pa cellosethyl cell y cell (40 ~ 80 ~) Wometera akhoza kukhala Pronsol Hlycol, succinic atcontruride, ulembrice anhydride ndi alunydride. Chuma chopingasa carboxymethyl chimagwiritsidwa ntchito ngati wothandizila mapiritsi, makapisozi ndi granules pokonzekera pakamwa, podalira kukopeka ndi mphamvu, mphamvu yake yopanda pake. Kafukufuku wawonetsa kuti kuchuluka kwa cellom
Methyl cellulose
Methyl cellulose (MC) ndi gawo limodzi la celluose ya ether yopangidwa kuchokera ku thonje ndi nkhuni pofika alkalization, chloromethane etheritetion ndi njira zina. Methyl cellulose imakhala ndi madzi abwino kwambiri osungunuka ndipo imakhazikika mu mankhunje a 2.0 ~ 13.0. Amagwiritsidwa ntchito kwambiri m'magulu ophatikizira, mapiritsi ankhanza, jammint mankhwala, kukonzekera kwa ophthalmic, mapiritsi apakamwa, mapiritsi a pakamwa ndi kukonzekera pakamwa ndi kukonzekera pakamwa. Kuphatikiza apo, MC itha kugwiritsidwa ntchito ngati ydrophilic humake yokhazikika, yosungunula yam'mimba, yosungunula, yotulutsidwa, yotulutsidwa, imasulidwa-mankhwala othandizira a mankhwala, etc.
Hydroxypropyl methyl cellulose
Hydroxypropyl me cellulose (hpmc) ndi ma cellulose osakanizidwa ndi thonje ndi nkhuni ndi alvalization ndi chloromethane. Ndiwopanda fungo, lopanda zokometsera komanso losalowerera, kusungunuka m'madzi ozizira ndi gelatinous m'madzi otentha. Hydroxypyl methy cellulose ndi zokolola zapakhomo, mlingo ndi mtundu wa mitundu ya eleulser m'zaka 15 zapitazi zikuyenda bwino kwambiri, monga kukomoka kwa zaka pafupifupi 50. Pakadali pano, kugwiritsa ntchito kwa HPMC kumawonekera makamaka m'mbali zisanu zotsatirazi:
Imodzi ili ngati binder ndi odzisamalira. HPMC Monga Chibwibwi chitha kupangitsa kuti mankhwalawa azikhala osavuta kunyowa, ndipo madzi ake omwe amatha kupititsa nthawi yambiri, chifukwa amatha kusintha chisungunule kapena kumasulidwa kwa mapiritsi. HPMC ili ndi mafakisoni olimba, chifukwa kapangidwe kazinthu zolimba za crisp kapena brattor zolimba kumapangitsa kuti tinthu tating'ono, kusintha kusiyana kwake. Mavinyewa otsika a HPMC akhoza kugwiritsidwa ntchito ngati chomangira komanso kusokonekera, mamasukidwe apamwamba ngati binder.
Lachiwiri lili ngati mawonekedwe omasulira pang'onopang'ono komanso owongolera kukonzekera pakamwa. HPMC ndichinthu cha hydrogel chomwe chimagwiritsidwa ntchito pokonzekera kumasulidwa. HPMC yokhala ndi milingo yotsika (5 ~ 50mmsa ~ itha kugwiritsidwa ntchito ngati zomatira, zomata zolimbitsa thupi, pomwe mapiritsi okhazikika, omwe amatulutsidwa Mapiritsi. HPMC imatha kusungunuka mumisala yamadzimadzi, ili ndi zabwino zopanga bwino, kuthekera kwamphamvu kwa madontho ndi kukonzekera kwa ma hydrophilic molimbika Zosangalatsa.
Chachitatu, ngati filimu yokutidwa - kupanga wothandizira. HPMC ili ndi mawonekedwe abwino a kanema, imapanga yunifolomu ya filimuyo, yowoneka bwino, yolimba, yovuta kungakhale yosavuta kukhazikika, makamaka ngati chinyezi chosavuta, chopewa kusinthasintha kwa mafilimu. HPMC ili ndi mafayilo osiyanasiyana, monga kusankha koyenera, kuphatikizira kwa filimu yoyenera, kumakhala bwino kuposa zinthu zina, zomwe zimagwiritsidwa ntchito kawiri kawiri, 10% ~ 10%.
Chachinayi ndi monga kapisozi kapisozi. M'zaka zaposachedwa, kufalikira pafupipafupi mliri wa nyama padziko lonse lapansi, poyerekeza ndi mapiritsi a gelatin, makapisozi azomera asandulika Darling watsopano wa malonda ndi chakudya. Pfizer yathamangitsa hpmc kuchokera ku mbewu zachilengedwe ndikukonzekera makapisozi a VCAPM. Poyerekeza ndi makapisozi a Gelatin, makapisozi amakapitsira ali ndi maubwino osinthika, palibe chiopsezo cholumikizirana ndi cholumikizira. Mlingo wopangidwa ndi mankhwalawo ndi wokhazikika, kusiyana kwa munthu ndi kocheperako, ndipo samayamwa pambuyo poti athetse mphamvu m'thupi la munthu, ndipo amatha kuchotsedwa m'thupi la thupi ndi ndowe. Pankhani yosungirako, kudzera mu kuyesa kwakukulu, makapisozi sakhala opanda chinyezi pansi pa mitembo yotsika, ndipo malo a makapisozi amakhazikika pansi pamatumbo akuluakulu, ndipo mndandanda wa makapisozi amakhudzidwa ndi mikangano yobzala kwambiri. Ndi kumvetsetsa kwa anthu kwa makapisozi azomera, komanso kusintha kwa mankhwala osokoneza bongo kunyumba ndi kunja, kufunikira kwa msika wamapisozi kumakula mwachangu.
Zisanu zili ngati wothandizira kuyimitsidwa. Kukonzekera kwamadzi komwe kumagwiritsidwa ntchito kawirikawiri mumitundu yazachipatala, yomwe ndi herurogeneous yobalalitsa machitidwe osokoneza bongo omwe amapezeka ndi ma media. Kukhazikika kwa dongosolo kumatsimikizira mtundu wa kukonzekera kwamadzi koyimitsidwa. HPMC Colloidal yankho la HPMC imatha kuchepetsa mikangano yokhazikika, kuchepetsa mphamvu zaulere za tinthu tokhazikika, kuti chisamboli chisumbuko chimakhala chokhazikika, ndi wothandizidwa bwino. HPMC imagwiritsidwa ntchito ngati makulidwe a madontho amaso, ndipo zomwe zili ndi 0,45% ~ 1.0%.
Hydroxypropyl cellulose
Hydroxypropyl cellulose (HPC) ndi imodzi yopanda ma cellulose ether opangidwa ndi thonje ndi nkhuni ndi alvalization ndi njira zina. HPC nthawi zambiri imasungunuka m'madzi pansi pa 40 ℃ ndi kuchuluka kwa polardent. Katundu wake ndi wokhudzana ndi zomwe zili hydroxypyl ndi digiri ya polymerization. HPC ikhoza kukhala yogwirizana ndi mankhwala osiyanasiyana ndipo imakhala ndi vuto.
Otsika ma hydroxypropyl cellulose (l - hpc) makamaka a piritsi, kuwoneka bwino zotsatira za cut.
Wam'mwamba kwambiri hydroxypropyl cellulose (H-HPC) itha kugwiritsidwa ntchito ngati chofunda cha piritsi, granule komanso granule mu gawo la pharmaceutical. H-HPC ili ndi katundu wabwino kwambiri wopanga, filimuyo yopezeka ndi yolimba komanso yotanuka, ndipo imatha kufananizidwa ndi pulasitiki. Mwa kusakanikirana ndi othandizira ena otsutsa, mafilimuwo amatha kukhalanso bwino, ndipo nthawi zambiri amagwiritsidwa ntchito ngati mawonekedwe okumba mapiritsi. H-HPC imatha kugwiritsidwanso ntchito ngati chimango chokomera chimango chosinthika, mapiritsi osuta fodya ndi mapiritsi osungunuka kawiri.
Hydroxyethyl cellulose
Hydroxyethyl cellulose (hec) ndi imodzi mwazitsulo zam'madzi zomwe zimapangidwa ndi thonje ndi nkhuni ndi alvalization, ethylee oxide. Hec imagwiritsidwa ntchito ngati thickener, othandizira othandizira colloidal, okonda kubereka, obalira, okhazikika, kupanga mankhwala othandizirana ndi kukhazikitsidwa. Itha kugwiritsidwa ntchito m'mankhwala am'madzi am'deralo, mafuta, madontho amaso, madzi amkamwa, mapiritsi olimba, makapisozi ndi mitundu ina ya mankhwala. Hydroxyathyl cellulose idaphatikizidwa ku United States Memist Wamalcopoeia / United States National Forelate ndi Europe wa MarU waku Europe Mereaccopoeia.
Ethyl cellulose
Ethyl cellulose (EC) ndi imodzi mwazomwe zimagwiritsidwa ntchito kwambiri pa cellulose. EC ndi yopanda mphamvu komanso yokhazikika, yokhazikika m'madzi, acid kapena alkali, sobeli, sothal ndi ena osungunulira. Ma sol sol sol ndi toleene / ethanol pakati pa 4/1 ndi kulemera. EC imagwiritsidwa ntchito zambiri m'matumba omasulidwa, amagwiritsidwa ntchito kwambiri ngati chonyamula mawonekedwe oletsedwa ndi mafilimu, zomata, zomwe zimagwiritsidwa ntchito ngati zophatikizika zam'madzi zisungunuke, zomwe zimagwiritsidwa ntchito ngati kunyamula Zipangizo zakukonzekera pang'onopang'ono Micro Capsule; Itha kugwiritsidwanso ntchito ngati nkhani zonyamula kuti zikonzekeretsedwe. Amagwiritsidwa ntchito kwambiri muukadaulo wamankhwala monga mawonekedwe a filimu ndi zokutira, komanso zomangira komanso zosefera. Monga chotetezera mapiritsi, chimatha kuchepetsa chidwi cha mapiritsi kuti chiwongolero chinyezi ndikuletsa mankhwalawa kuti asakhudzidwe ndi chonyowa komanso chosakanizira. Itha kupanganso chosanjikiza chomata pang'onopang'ono ndikuyika polymer yomwe ili ndi ma microcapsules, kotero kuti mankhwalawa atha kumasulidwa mosalekeza.
Titha kuchotsa pakati - ndi zomaliza zotsirizika ndikuthandizira kusintha ndikukweza
Kuwerenga, kusungunuka kwamadzi ma carboxyl cellouse, methyl cellulose, ngati mafuta, popunthira pakamwa pang'onopang'ono, kapisozi kapisozi komanso thandizo loyimitsidwa lomwe limagwiritsidwa ntchito muzomwe zimathandizira. Kuyang'ana padziko lapansi, makampani angapo akunja akunja (Japan Shin-Etsa, Etesu, United States TOlf ndi Akhungu) Dow adalengeza kuti izi zidzathetsa mawonekedwe, zosakaniza ndi zosowa pamsika wa China, komanso zoyesayesa zake zobweretsa kafukufuku wapafupi ndi msika. Kugawa kwa cellulo ndi utoto wa cellulose kwakhazikitsa mgwirizano wapadziko lonse lapansi kuti atulutsidwe, ali ndi antchito oposa 1,200 ndi maofesi 6 a GM, ndipo akatswiri ofufuza ambiri amagwira ntchito makasitomala m'maiko pafupifupi mamayiko 160. Anzake ali ndi malo opanga mu Beijing, Shanghai, Nanzihai, nanong, angzhan, angshan ndi Jiangmen, ndipo wapereka ma Ceftonel Cleali ndi nanjing.
Malinga ndi tsamba la webusayiti ya China Ether Ether Association, mu 2017, zidachitika za ethel ethel ethel ethel zinali matani 373,000, ndipo voliyumu yogulitsa inali matani 360,000. Mu 2017, kuchuluka kwa mankhwalawa a Ionic CMC kunali matani 234,000, mpaka 18.61 Zogulitsa zopanda Ionic Kuphatikiza pa HPMC (zomangira), hpmc (mankhwala a HPMC (Fpmc), HPM), HPC, HPC, HPC, HPMC, HPMC, HPMC, HPMC Ma Ether Cellulose ether akukula mwachangu kwa zaka zoposa khumi, zopangidwa ndi ma etherbizinesi a celluuse zimagwiritsidwa ntchito makamaka kumapeto kwa malonda, mtengo wowonjezereka siwokwezeka.
Ma exuluse ether etherbise kunyumba ndi kunja, makamaka panthawi yovuta yosinthira ndikukweza malonda kuti athe kusinthana ndi malonda, amazindikira za chitukuko chambiri.
Post Nthawi: Jan-27-2022