Zowonjezera za mankhwala ndizosangalatsa komanso zowonjezera zomwe zimagwiritsidwa ntchito popanga mankhwala ndi malangizo, ndipo ndi gawo lofunikira pakukonzekera kwa mankhwala. Monga chilengedwe cha polymer odetsedwa, cellulose ethergradgle, osakhala poizoni, komanso otsika mtengo, monga cellolithyl cellolithyl cellose ali ndi mtengo wofunikira mu Zosangalatsa za mankhwala. Pakadali pano, zopangidwa ndi ma etherpulic ethermic ma cellulose zimagwiritsidwa ntchito makamaka m'minda yapakati ndi yotsika kwambiri ya mafakitale, ndipo mtengo wowonjezereka siwokwezeka. Makampaniwa amafunikira kusintha komanso kukweza kusintha kwa zinthu zomaliza.
Kutha kwa msika kumathandizira
Zofunikira za mankhwala opangira zimatenga gawo lofunikira pakupanga ndi kupanga. Mwachitsanzo, mumasulidwa-kutukwana, zida zomasulira monga ma cellulose zimagwiritsidwa ntchito ngati mankhwala omasulira, matepi okhazikika, amasulidwa mafilimu omasulidwa, ndikusintha mankhwala osokoneza bongo. Kukonzekera ndi kukonzekera kwamadzi kokhazikika kwagwiritsidwa ntchito kwambiri. M'dongosolo lino, ma polima monga etheluse ethelose nthawi zambiri amagwiritsidwa ntchito ngati mankhwala onyamula mankhwala omwe angayang'anire kumasulidwa kwa mankhwala osokoneza bongo m'thupi la munthu.
Malinga ndi ziwerengero kuchokera ku dipatimenti yophunzira za ZHyan, pali mitundu pafupifupi 500 yomwe yatchulidwa mu dziko langa, koma poyerekeza ndi United States (mitundu yoposa 3,000), mitundu ikuluikulu idakalipo pang'ono. Kutha kwa msika ndi kwakukulu. Zimamveka kuti zothandizira khumi ndi zoyambira pamsika wa dziko la gelatin ndi makapisozi, owuma, ma pvmc, hydrox, ma celctose.
Makina asanu ndi limodzi ophatikizira a cellulose ether
Ethel cellulose ether ndi mawu ambiri opanga ma cellulose omwe amapangidwa ndi zomwe alkali adazigwiritsa ntchito cellulose ndi kukhazikika kwamikhalidwe. Ndi chinthu chomwe ma gydroxyl magulu omwe ma cellulole macromolecles amakhala osachedwa kapena m'magulu a ether. Cellulose eder amagwiritsidwa ntchito kwambiri m'minda ya mafuta, zomangira, zokutira, chakudya, mankhwala ndi mankhwala amtsiku ndi tsiku. M'magawo osiyanasiyana, malo ogulitsira a garrmaceutical amakhala m'minda yapakati komanso yayitali kwambiri yamakampaniyi, ndi mtengo wowonjezereka. Chifukwa chofunafuna zofunikira, kupanga kwa cellulose ethelose ether kulinso kovuta. Titha kunenedwa kuti mtundu wa zinthu zamankhwala zamankhwala umatha kuyimira mphamvu yaukadaulo ya ethel ether. Cellulose ether nthawi zambiri imawonjezeredwa ngati blocker, matrix ndi ofiira kuti atulutse ma matrix a matrix, zosuta zosungunuka, zomwe zidatulutsidwa-zolimbikitsidwa-zopendekera - zida zosemetsera zida, etc.
Sodium carboxymethyl cellulose
Carboxymethyl cellulose sodium (cmc-na) ndi ma cellulose opanga ndi zolengedwa zazikulu kwambiri komanso zakunja. Ndi cellulose ya ionic ether yopangidwa ndi thonje ndi nkhuni kudzera mu alkirization ndi kumasuka ndi chlorooceic asidi. CMC-na ndi yogwiritsidwa ntchito kawirikawiri. Nthawi zambiri imagwiritsidwa ntchito ngati khola yokonzekera kukonzekera, kuwunika, kukulira ndi kuyimitsa mankhwalawa kukonzekera kwamadzi, ndipo kumatha kugwiritsidwanso ntchito ngati matrix osungunuka ndi mafilimu. Nthawi zambiri imagwiritsidwa ntchito ngati chodziletsa - matriti okhala ndi matrix omwe amasulidwa mu chikhazikitso (olamulidwa) kumasulidwa.
Kuphatikiza pa sodium carboxymethylmelose ophatikizidwa, croscarmaker sodium imatha kugwiritsidwanso ntchito ngati mankhwala osokoneza bongo. Croscarmengase sodium (CCMC-NA) ndi mankhwala osokoneza bongo a carboxymethylceluloulose yokhudzana ndi wothandizirana ndi kutentha pa kutentha kwina (40-80 ° C) pansi pa chothandizira a avoric acid ndi kuyeretsedwa. Monga momwe wothandizira, Propylene Glycol, succinic ansehyruride, ulembrice andhydride ndi anipric tehydride angagwiritsidwe ntchito. Solcarmembalase Sodium imagwiritsidwa ntchito ngati chosowa mapiritsi, makapisozi ndi ma granules pokonzekera pakamwa. Imadalira pa capillary ndi kutupa kuti asokonezeke. Ili ndi kusiyana pakati pa kukakamiza kwamphamvu. Kafukufuku wasonyeza kuti kutupira kwa croscarmemelase m'madzi ndizambiri kuposa kusokoneza kozama monga sodium yotsika kwambiri cellulose.
Methylcellulose
Methyl cellulose (MC) ndi cellulose yopanda ionic imodzi ya ether yopangidwa ndi thonje ndi nkhuni kudzera mu alkalization ndi methyl chloride. Methylcellulose imakhala ndi solubility yamadzi abwino kwambiri ndipo imakhazikika mu ph2.0 ~ 13.0. Amagwiritsidwa ntchito kwambiri m'magulu ogulitsa mankhwala, ndipo amagwiritsidwa ntchito mapiritsi apanyumba, kukonzekera kwa mafirusmic, makapisozi apakamwa, mapiritsi a pakamwa ndi kukonzekera pakamwa ndi kukonzekera pakamwa ndi kukonzekera pakamwa. Kuphatikiza apo, pakukonzekera kutukuka, MC itha kugwiritsidwa ntchito ngati hydrophilic gel osungunuka, kutulutsa zitsulo zosungunula, kutulutsa mic derocopsule zokutira, zida zodziletsa-zopangidwa-zimasulidwa.
Hydroxypropropylmethycelulose
Hydroxypropyll methylcellulose (hpmc) ndi ma cellulose osakanikirana opangidwa ndi thonje ndi nkhuni kudzera mu alkalization, proyyl chleride. Ndiwopanda fungo, wopanda pake, wopanda poizoni, sungunuka m'madzi ozizira ndikumangirira m'madzi otentha. Hydroxypylropyl ndi mankhwala osokoneza bongo omwe amapanga mitundu ya Etherse omwe amapanga, zomwe mlingo ndi mtundu wachulukirachulukira ku China zaka 15 zapitazi. Ndi imodzi mwazomwe zimagwiritsidwa ntchito kwambiri zophatikizira kunyumba ndi kunja. zaka zingapo. Pakadali pano, kugwiritsa ntchito HPMC kumawonetsedwa makamaka muzinthu zisanu zotsatirazi:
Limodzi ndi lonyowa komanso wopanda pake. Monga binder, hpmc imatha kupangitsa mankhwalawa kunyowa, ndipo amatha kuchulukitsa kanthawi kochepa pambuyo potenga madzi, kotero amatha kusintha muyeso wa chilengedwe kapena kumasulira kwa piritsi. HPMC ili ndi mafayilo olimba, omwe amatha kukulitsa mawonekedwe a tinthu tating'onoting'ono ndikusintha zosokoneza zomwe zili ndi zida zopangira ndi crisp kapena brity. HPMC yokhala ndi mafayilo otsika imatha kugwiritsidwa ntchito ngati binder ndi kuwonongeka, ndipo omwe ali ndi mafayilo apamwamba amatha kugwiritsidwa ntchito ngati binder.
Lachiwiri lili ngati njira yotulutsidwa komanso yowongolera yokonzekera kukonzekera pakamwa. HPMC ndi nkhani yogwiritsidwa ntchito pokonzekera matrix pakukonzekera kokhazikika. Kalasi yotsika kwambiri (-50MPA phompho (-50MPA jpmc ikhoza kugwiritsidwa ntchito ngati binder, viscosiriff ndi kuyimilira) mapiritsi osakanikirana, ndi mapiritsi a Hydrophilic Gel. HPMC imasungunuka m'mimba, ili ndi maubwino okonderemiza ndi zinthu zabwino, mankhwala osokoneza bongo, ndi mankhwala omasulira osakhudzidwa ndi Ph. Ndi nkhani yofunika kwambiri ya hydrophilic kwambiri mu njira zopangira magetsi ndipo nthawi zambiri imagwiritsidwa ntchito ngati hydrophilic gel osakhalitsa kukonzekera kwa matrix ndi zothandiza pakukonzekera kwam'mimba ndikukonzekera kugwiritsa ntchito mankhwala a mankhwala osokoneza bongo.
Wachitatu ali ngati wothandizira makanema. HPMC ili ndi katundu wabwino wopanga mafilimu. Kanema wopangidwa ndi iwo ndi yunifolomu, wowonekera komanso wovuta, ndipo sizophweka kumamatira. Makamaka mankhwala omwe ndi osavuta kuyamwa ndi osakhazikika, pogwiritsa ntchito ngati mawonekedwe osungunuka amatha kusintha kwambiri kukhazikika kwa mankhwalawa ndikuletsa filimuyo imasintha mtundu. HPMC ili ndi mafayilo osiyanasiyana. Ngati mwasankhidwa moyenera, mawonekedwe ndi mawonekedwe a mapiritsi okutidwa ndi apamwamba kuposa zinthu zina. Kugwiritsa ntchito mokhazikika ndi 2% mpaka 10%.
Chachinayi ndi monga kapisozi. M'zaka zaposachedwa, kufalikira pafupipafupi kwa zilonda za nyama zapadziko lonse, poyerekeza ndi mapiritsi a gelatin, makapisozi a masamba asandulika danga latsopano la mafakitale ndi chakudya. PFINE ya United States yatha bwino ndi HPMC kuchokera ku mbewu zachilengedwe ndikukonzekera masamba a VCAPMM. Poyerekeza ndi zipilala za Gelatin Holow, makapisozi amoto ali ndi maubwino osinthika kwambiri, palibe chiopsezo cholumikizirana ndi kukhazikika kwamphamvu. Mlingo wopangidwa ndi mankhwalawo ndi wokhazikika, ndipo kusiyana kwako ndikochepa. Pambuyo kusokonezedwa m'thupi la munthu, sichimayanjidwa ndipo chimatha kuchotsera thunthu lomwe limatulutsidwa ndi thupi. Potengera malo osungirako, atatha mayeso angapo, sizikhala zopanda malire pansi pa chinyezi chotsika, ndipo katundu wa chipolopolo wa kapisozi adakhazikika pansi pa mikhalidwe yayitali, ndipo zisonyezo za makapisozi azomera sizikhudzidwa kwambiri. Ndi kumvetsetsa kwa anthu kwa makapisozi ndi kusintha kwa malingaliro a anthu kunyumba ndi kunja, kufunikira kwa msika kumera makapisozi kumakula mwachangu.
Wachisanu ali ngati womangirira. Kuyimitsidwa-kukonzekera kwamadzimadzi kumagwiritsidwa ntchito kwa mankhwala owonjezera, omwe ndi mtundu wobalalika womwe umakhala ndi mphamvu zomwe zimapezeka kawirikawiri mankhwala omwe amamwa mowa. Kukhazikika kwa dongosololi kumatsimikizira mtundu wa kukometsedwa kwamadzi kukonzekera. HPMC Colloidal yankho la HPMC imatha kuchepetsa mavuto okhazikika, kuchepetsa mphamvu yaulere ya tinthu tokha, ndikukhazikitsa chizolowezi chobalalitsa. Ndi woyimba bwino. HPMC imagwiritsidwa ntchito ngati thickener ya madontho amaso, yokhala ndi 0,45% mpaka 1.0%.
Hydroxypropyl cellulose
Hydroxypropyl cellulose (hpc) ndi ma cellulose omwe siamodzi a ether opangidwa ndi thonje ndi nkhuni kudzera pa alkirization ndi ma propylene oxide. HPC nthawi zambiri imasungunuka m'madzi pansi pa 40 ° C ndi kuchuluka kwa polant, ndipo ntchito yake imakhudzana ndi zomwe zili ndi ma hydroxypyl gulu la polyroulization. HPC ikhoza kukhala yogwirizana ndi mankhwala osiyanasiyana ndipo imakhala ndi vuto.
Ma hydroxypropyl otsika cellulose (L-HPC) imagwiritsidwa ntchito ngati piritsi. -Hpc imatha kusintha kuuma ndi kuwala kwa piritsi, ndipo amathanso kupanga piritsi linalake mwachangu, kusintha mtundu wa piritsi, ndikuwongolera phindu.
Kukhazikika kwambiri hydroxypropyl cellulose (H-HPC) itha kugwiritsidwa ntchito ngati chomangira mapiritsi, magaleta, komanso magaleta abwino mu gawo la pharmaceutical. H-HPC ili ndi katundu wabwino kwambiri wamakanema, ndipo filimu yomwe idapezekayo ndi yolimba komanso yotanuka, yomwe imatha kufananizidwa ndi mafayilo. Kuchita kwa filimuyo kumatha kusintha mwa kusakanikirana ndi othandizira ena ophatikizika, ndipo nthawi zambiri amagwiritsidwa ntchito ngati zokutira kanema mapiritsi. H-HPC imatha kugwiritsidwanso ntchito ngati chidziwitso cha matrix kuti akonzekere mapiritsi osuta matrix, ma pellets osuta fodya ndi mapiritsi osungulumwa kawiri.
Hydroxyethyl cellulose
Hydroxyethyl cellulose (hec) ndi cellulose yopanda ionic imodzi ya ether yopangidwa ndi thonje ndi nkhuni kudzera mu ma alkirization ndi kumayambiriro kwa ethylene oxide. Mu gawo la mankhwala, hec imagwiritsidwa ntchito ngati thicker, wothandizira Colloidal, wololera, wogwirizira, madontho amagetsi, piritsi lolimba, kapisozi zina. Hydroxyethyl cellulose yalembedwa mu US Pharmacopoeia / US National Challalary ndi European pharmacopoeia, etc.
Ethyl cellulose
Ethyl cellulose (EC) ndi imodzi mwazomwe zimagwiritsidwa ntchito kwambiri pa cellulose. EC ndi yopanda mphamvu, yokhazikika, yokhazikika m'madzi, acid kapena alkali kapena alkali. Zogwiritsidwa ntchito kwambiri zosungunulira ndi tolhanul / ethanol ngati 4/1 (kulemera) kusungunuka. EC ili ndi magwiridwe angapo pokonzekera kukonzekera bwino ogwiritsidwa ntchito ngati zolemba zothandiza kuti zikonzekere mic nyama yotulutsidwa; Itha kugwiritsidwanso ntchito ngati chinthu chonyamulira pokonzekera kupezeka kolimba; Kugwiritsidwa ntchito kwambiri muukadaulo wamankhwala monga chinthu chopanga mafilimu ndi zokutira, komanso zomangira komanso zosefera. Monga chomangira piritsi, chimatha kuchepetsa chidwi cha piritsi kuti chiwongolero chinyezi ndikuletsa mankhwalawo kuti asakhudzidwe ndi chinyontho, osasunthika ndi kuwonongeka; Itha kupanganso pang'onopang'ono kutulutsa kwapang'onopang'ono, microencapsiste polymer, ndikupangitsa kuti kumasulidwa kwa mankhwalawa.
Chotsani mapulogalamu omaliza otsika ndikuthandizira kusintha ndikukweza
Mwachidule, sodium-soduble sodium carboboboxymethyl cellose, methyl cellulose, hydroxypropyl cellose, kusokoneza, kusakhazikika komanso kusungidwa. Zipangizo zamakonzedwe okonzekera mkamwa, zophatikiza mafilimu, zinthu zopanga makapisozi ndi mafoni osiyitsa. Kuyang'ana padziko lapansi, makampani angapo akunja akunja (Shin-Emfa Japan, Dow Wolfe ndi Ashland Cronch chinjoka) ntchito mkati. Dounje lolengezedwa kuti lilimbikitse kuyang'ana kwake, zosakira ndi kufunikira kwa msika waku China zam'madzi, ndipo kafukufuku wake amayesetsa kuti ayandikire kumsika. Dowe Mankhwala Olff Cellolise Division ndi ColourCon Corporation of the United States yakhazikitsa mgwirizano padziko lonse lapansi, okhala ndi mabungwe oposa 1,200, ochita masewera ambiri, omwe amagwiritsidwa ntchito kwambiri amagwiritsa ntchito makasitomala m'maiko pafupifupi mamayiko 160. Ashland ali ndi zokutira zopanga ku Beijing, Shanghai, Nanzihai, angzhou, angshan ndi a Jiangmen malo ophunzitsira mu Shanghai ndi nanjing.
Malinga ndi ziwerengero kuchokera patsamba la China cellulose mayanjano, mu 2017, kupanga pazaka zapakhomo 363,000, ndipo voliyumu yogulitsa inali matani 360,000. Mu 2017, kuchuluka kwenikweni kwa Ionic CMC kunali matani 234,000, kuchuluka kwa chaka cha 18.61%, komanso kuchuluka kwa matani 126,000, kuchuluka kwa chaka cha 8.2%. Kuphatikiza pa HPMC (yomanga malo), zinthu zosafunikira), HPMC (HPMC (HPMC), HPM, HPC, ETC. Awo apitilizabe kuwonjezeka. Cellulose wapanyumba ether akukula mwachangu kwa zaka zopitilira khumi, ndipo zotuluka zake zayamba kukhala woyamba padziko lapansi. Komabe, zopangidwa ndi makampani ambiri a celluse zimagwiritsidwa ntchito m'minda yapakati komanso yotsika kwambiri yamakampaniyi, ndipo mtengo wowonjezereka siwokwezeka.
Pakadali pano, ma celluuse ambiri a celluse ali nthawi yovuta yosintha ndikukweza. Ayenera kupitiriza kuwonjezera ntchito zofufuzira za mankhwala ndi chitukuko, mosalekeza othandizana ndi china, msika waukulu kwambiri padziko lonse lapansi, ndikuwonjezera ntchito zapakatikati komanso zowonjezera.
Post Nthawi: Jun-15-2023