Tiyeni tikambirane za hydroxypropyl methyl cellulose HPMC ndi momwe tingayezere kukhuthala kwake.Kukhuthala kwamphamvu apa kukutanthauza kukhuthala kowoneka bwino, komwe ndikofunikira kwambiri ku hydroxypropyl methyl cellulose.
Standard.Njira zoyezera nthawi zonse ndi kuyeza kwa kukhuthala kozungulira, kuyeza kukhuthala kwa capillary ndi kuyeza kukhuthala kwa kugwa.Njira yotsimikizika ya hydroxypropyl methyl cellulose inali kumatira kwa capillary.
Njira yodziwira digiri, pogwiritsa ntchito viscometer ya Uchs.Nthawi zambiri kutsimikiza kwa yankho ndi 2% yankho lamadzi, chilinganizo ndi: V=Kdt.V ndi kukhuthala kwa mpa.s ndi K ndi viscometer yokhazikika.
D ndi kachulukidwe pa kutentha kosasintha ndipo T ndi nthawi yochokera pamwamba mpaka pansi kudzera mu viscometer mumasekondi.Njira iyi yogwirira ntchito ndi yovuta kwambiri, ngati pali zinthu zosasungunuka.
Mawu ndi osavuta kuyambitsa zolakwika, ndizovuta kuzindikira mtundu wa hydroxypropyl methyl cellulose.Tsopano amagwiritsidwa ntchito poyesa kukhuthala kwa viscometer yozungulira, yomwe imagwiritsidwa ntchito ku China.
Njira ya NDJ-1 viscometer ndi η=Kα.η ndi kukhuthala, komanso mu mpa.s, K ndiye coefficient ya viscometer, ndipo α ndi kuwerenga kwa viscometer pointer.
Hydroxypropyl methyl cellulose 2% viscosity test njira:
1, njira iyi ndi yoyenera kutsimikiza kwa kukhuthala kwamphamvu kwamadzi omwe si a Newtonian (polymer solution, kuyimitsidwa, emulsion dispersion fluid kapena surfactant solution, etc.).
2. Zida ndi zida
2.1 Rotary viscometer (NdJ-1 ndi NDJ-4 ikufunika ndi Chinese Pharmacopoeia)
2.2 Nthawi zonse kutentha madzi kusamba nthawi zonse kutentha molondola 0.10C
2.3 Digiri ya kutentha ndi 0.20C, yomwe imatsimikiziridwa nthawi ndi nthawi.
2.4 Mamita pafupipafupi Ma Viscometers pogwiritsa ntchito miyeso yokhazikika pafupipafupi (monga NDJ-1 ndi NDJ-4) adzasungidwa.Kulondola kwa 1%.A
8. Chitsanzo cha Og chinayesedwa bwino ndikuyikidwa mu beaker yowuma, yokhala ndi matani 400mL wamtali.Onjezerani pafupifupi 100mL ya 80-90 digiri ya madzi otentha ndikuyambitsa 10min kuti mulekanitse.
Mosiyana kumwazikana, kusonkhezera ndi kuwonjezera madzi ozizira kwa 400mL onse.Pakadali pano, yambitsani mosalekeza kwa 30min kuti mupange yankho la 2% (W / W), ndikuyiyika mufiriji kuti madzi oundana azizizira mpaka atapanga ayezi wochepa kwambiri pamwamba.
Chotsani ndikuyika mu thanki yotentha yokhazikika kuti kutentha kwapakati ku 20 ℃ 0.1 ℃.
3.1 Kuyika ndi kugwiritsa ntchito chidacho kudzachitika motsatira malangizo ogwiritsira ntchito chidacho, ndipo rotor yoyenera ndi rotor zidzasankhidwa molingana ndi makulidwe amakanema azinthu zomwe zayesedwa ndi zomwe pharmacopoeia imaperekedwa pansi palemba la mankhwala
Liwiro lozungulira.
3.2 Sinthani kutentha kwa madzi nthawi zonse malinga ndi kutsimikiza pansi pa chinthu chilichonse cha mankhwala.
3.3 Choyesereracho chinayikidwa mu chidebe chomwe chidafotokozedwa ndi chidacho, ndipo mbali yolowera (a) idayesedwa motsatira malamulo pambuyo pa mphindi 30 kutentha kosalekeza.Zimitsani injini ndikuyiyambitsanso kuti mutsimikizirenso
Kusiyanitsa pakati pa zikhalidwe zapakati sikuyenera kupitirira 3%, apo ayi muyeso wachitatu uyenera kupangidwa.
3.4 Kuwerengera mtengo wamtengo wapatali wa mayesero awiriwa molingana ndi ndondomeko kuti mupeze kukhuthala kwamphamvu kwa mankhwala oyesedwa.
4. Lembani ndikuwerengera
4.1 Lembani chitsanzo cha rotary viscometer, nambala ya rotor ndi liwiro logwiritsidwa ntchito, viscometer yosasintha (K 'mtengo), kutentha kwake, ndi muyeso uliwonse.Mtengo.
Njira yowerengera ya 4.2
Dynamic viscosity (MPa”s)=Ka pomwe K ndi kachidutswa kakang'ono kamene kamapimidwa nthawi zonse ndi madzi odziwika a viscosity odziwika ndipo A ndiye mbali yokhotakhota
Nthawi yotumiza: May-18-2022