HPMC ndi chiyani?

Hpmc hydroxypypyl methylcellulose, omwe amadziwikanso kuti hypromellose, ndi amodzi mwa ma cellose osakaniza ndi ionic osakanizika Ndiko kupanga polymer, ma viscoelastic, ma visme ogwiritsidwa ntchito ngati mafuta mu ophthalmology, kapena ngati prophum kapena yodzaza ndi mankhwala am`kamwa.

Katundu Wopanga Verroxypyll Methyl Cellose (HPMC)
Dzina lina la hydroxpyl methylcellulose, mhpc, methyl hydroxypropyl cellulose
Kulembetsa kwa Cas nambala 9004-65-3
Mawonekedwe oyera kapena granlar ufa
Kufotokozera kwa chitetezo S24 / 25

Mankhwala ndi mankhwala
Maonekedwe: oyera kapena pafupifupi oyera kapena granlar ufa
Kukhazikika: Mautives amayaka komanso osagwirizana ndi oxidals amphamvu.
Malalanje; Kupitilira kwa mauna 100 kunali kopitilira 98,5%. Kutha kwa maso 80 ndi 100%. Kukula kwapadera kwa tinthu tambiri 40 ~ 60 mesh.
Kutentha Kwa Kada: 280-300 ℃
Zowoneka bwino: 0.25-0.70g / cm3 (nthawi zambiri kuzungulira 0,5g / cm3), mphamvu yokweza 1.26-1.31.
Kutentha Kwa Mtundu: 190-200 ℃
Matendawa: 42-56dyd / cm mu 2% yam'madzi
Kusungunuka: kusungunuka m'madzi ndi ena mabedi, monga gawo loyenerera la ethanol / madzi, propyal / madzi, etc. Kuwonekera kwakukulu, kusakhazikika, njira zosiyanasiyana zamagetsi ndi zosiyana, kusintha kosungunuka ndi mawonekedwe, njira yosinthira, hpmc yankho la madzi sinakhudzidwe ndi mtengo.
Ntchito ya HPMC idatsika ndi kuchepa kwa methoxyl, kuwonjezeka kwa gel osakaniza ndi kuchepa kwa madzi kusandulika madzi.
HPMC ilinso ndi luso lakumwamba, kukana mchere phulusa, phwete la pH, kusungunuka kwamadzi, mawonekedwe abwino kwambiri opanga enzyme, obalalika ndi mikhalidwe yolumikizira.

Njira Zopangira
Celloto yoyengayoya bwino imathandizidwa ndi Lye pa 35-40 ℃ theka la theka la ora, limapanikizika, cellulose imaphwanyidwa ndi zaka 35 Ikani fiberi ya alkali mu ketulo yoyeserera, onjezani ma proreyne oxide ndi methane chloride molakwika, kwezani pa 50-80 ℃ kwa 5h, kukakamizidwa kwambiri kuli pafupifupi 1.8MPA. Kenako onjezani kuchuluka kwa hydrochloric acid ndi oxalic acid kutsuka zida mu 90 ℃ madzi otentha kukulitsa voliyumu. Madzi omwe ali pazinthuzo ali ochepera 60%, imawuma mpaka 5% ndi mpweya wotentha nthawi ya 130 ℃. Pomaliza, chomalizidwacho chimaphwanyidwa ndikuwombedwa pa ma mesh 20.

Njira Yokhutira
1, mitundu yonse ikhoza kuwonjezeredwa ku zinthu ndi njira youma yosakanikirana.
2, ayenera kuwonjezeredwa mwachindunji kwa njira yamadzi yotentha, ndibwino kugwiritsa ntchito kupezeka kwa madzi ozizira, mutatha kuwonjezera mu mphindi 10-90 kuti munene.
3. Mitundu wamba imatha kusungunuka mutasakanikirana ndi madzi otentha ndikuwonjezera madzi ozizira pambuyo poyambitsa ndikuzizira.
4. Posungunula, ngati chodabwitsa cha zigawenga zamavuto chimachitika, chifukwa chifukwa kusakaniza sikokwanira kapena mitundu wamba kumawonjezeredwa mwachindunji kwa madzi ozizira. Pakadali pano, ziyenera kusunthidwa mwachangu.
5.

Kugwiritsa Ntchito HPMC
Amagwiritsidwa ntchito ngati thickener, wobalalitsa, bander, zotsekemera, zokutira zosagwira mafuta, zosefera, emulsifier ndi kukhazikika m'makampani opanga malemba. Chomwe chimagwiritsidwanso ntchito kwambiri mu malo opangira, petrochemical, ceramic, pepala, chikopa, mankhwala, chakudya ndi mafakitale ena.

Cholinga chachikulu
1, makampani omanga: Monga matope a simenti madzi osungitsa madzi, matope obwezeretsa ndi kupompa. Mu zopaka, gypsum, putty ufa kapena zinthu zina zomangira monga zomatira, sinthani nthawi ya opareshoni. Kugwiritsidwa ntchito polemba ceramic matayala, mabo, zokongoletsa pulasitiki, amalimbikitsa kuti muchepetse mlingo wa simenti. Magwiridwe antchito a HPMC amapangira slurry mutatha kugwiritsa ntchito pouma kwambiri komanso kuswa, kumawonjezera mphamvu pambuyo polimbana.
2, kupanga kapangidwe kake: kugwiritsidwa ntchito kwambiri ngati kotani mu kapangidwe kake.
3, makampani okutira: Makampani okutira ngati thiccener, wobayira komanso kukhazikika, m'madzi kapena osungunuka amakhala ndi kusungunuka bwino. Ngati utoto.
4, kusindikizidwa kuvumbitsirani: mu makampani a inki monga Thicker, wobayira komanso kukhazikika, m'madzi kapena osungunuka amakhala ndi kusungunuka bwino.
5, pulasitiki: pakupanga mamasulidwe, sofener, mafuta, etc.
6, pvc: Kupanga kwa PVC ngati kubadwa, Kukonzekera kwa polymerization kwa PVC Main Arexiliaries.
7, makampani ogulitsa mankhwala: Zipangizo zokutira; Nkhani za member; Kuchuluka kwa polymer-ma polymer kuti akonzekere kukongola; Wothandizira; Imayimitsidwa; Piritsi lomatira; Zimawonjezera goo
8, ena: Amenenso amagwiritsidwa ntchito kwambiri m'chikopa, mapepala amapanga mapepala, zipatso ndi mafakitale komanso makampani ojambula.

Ntchito yopanga mafakitale

Makampani omanga
1, matope a simenti: Kupititsa patsogolo kubadwa kwa simenti - mchenga, kusintha kwambiri matoputala ndi kusungidwa kwamadzi kwa matope, kuteteza ming'alu kumatha, kumatha kukulitsa mphamvu ya simenti.

2, sitamite wa matabwa a ceramic tator, kusungidwa kwamadzi, kusungirako madokotala ndi mataumba tile, kupewa ufa.
3, Asbestos ndi zokutira zina: Monga wothandizira kuyimitsidwa, wowongolera amadzimadzi, komanso kusintha gulu lonse.
4, gypsum slurry: Sinthani kusungidwa kwamadzi komanso kusachita bwino, kukonza zitsamba za maziko.
5, simenti yolumikizana: Onjezani mu bolodi la gypsum ndi simenti yolumikizana, sinthani madzi ndi kusungidwa kwamadzi.
6.
7, matope: Monga choloweza mmalo mwa mawonekedwe achilengedwe, amatha kusintha kusungidwa kwamadzi, kukonza gululo mokwanira ndi maziko.
8, zokutira: ngati pulasitiki ya zokutira za latex, ili ndi gawo losintha magwiridwe antchito ndi madzi okutira ndi ufa.
9, Kupatula kwa Spring: Kuteteza simenti kapena kuthira kwa posachedwapa kokha kokha kolowera ndikuwongolera zojambula zowoneka bwino ndi zotupa zotupa zimakhala ndi zotsatira zabwino.
10, simenti, gypsum sekondale - monga simenti - asbestos ndi zinthu zina za hydralic zimakanikiza zofunda, kusintha madzimadzi, kumatha kupanga zinthu zosungunulira yunifolomu.
11, khoma la fiber: Chifukwa cha anti-enzyme anti-bacymeal, monga khoma la khoma lamchenga limagwira ntchito.
12, Zina: itha kugwiritsidwa ntchito ngati gawo lowonda matope ndi matope ogwiritsa ntchito kuwira.

Makampani Amakampani
1, vinyl chloride, vinyl polymerization: monga ma polymerization kuyimitsidwa, kumwa mowa kwa vanyl (pvac) ndipo amatha kuwongolera kugawa kwa tinthu tating'onoting'ono ndi tinthu.
2, zomatira: Monga ma Wallpaper opindika, m'malo mwa owuma nthawi zambiri imatha kugwiritsidwa ntchito ndi vinyl acetate acetate wa molx zophimba.
3. Mankhwala ophera tizilombo: Kuwonjezeredwa kwa mankhwala ndi herbicides, zimatha kusintha zotsatira za kuponderezedwa pomwe kupopera mbewu mankhwalawa.
4, latex: Sinthani phula emulsion Stateer, styrene butadiene rabara (SBR) LICKER.
5, Bunger: Monga pensulo, koryoni kupanga zomatira.

Makampani opanga zodzikongoletsera
1. Shampoo: Sinthani mawonekedwe ndi kukhazikika kwa ma thonje, zotsekemera ndi zotchinga.
2. Mankhwala a mano: kusintha madzimadzi amtundu wa mano.

Makampani Ogulitsa Zakudya
1, zamzitini za zipatso: kupewa kusungidwa chifukwa cha kuwonongeka kwa lalanje glycosides ndi kuyerekeza metalikali kuti athe kukwaniritsidwa.
2, Zowonjezera Zozizira: Onjezani mame a zipatso, ma Ice sing'anga, pangani kukoma kwabwinoko.
3, msuzi: Monga msuzi, msuzi wa phwetekere wolowerera kapena kukula.
4, madzi ozizira ozizira: Kugwiritsidwa ntchito kwa nsomba zozizira, kuchepetsa kuchepa kwa ma cellulose kapena hydroxyprose celyl celying, kenako ndikuzizira pa ayezi.
5, zomata za mapiritsi: monga kupanga mapiritsi ndi mapiritsi, kugwiriridwa ndi kugwa (kusungunuka (kusungunuka) ndikubalalika mukamatenga.

Makampani opanga mankhwala
1. Zokutira: Wophatikiza wolumikizirayo amapangidwa kukhala njira yolozera kapena yankho la madzi am'mapirire, makamaka kuti tinthu tating'ono tating'ono tosiyanasiyana.
2, Wochepera Pansi: 2-3 magalamu patsiku, nthawi iliyonse 1-2g Mlingo, m'masiku 4-5 kuti muwonetse zotsatira zake.
3, mankhwala m'maso: chifukwa kukakamizidwa kwa OSMOXYPYPYPSL Spelluse njira yothetsera vutoli ndi yofanana ndi misozi, yowonjezera zamaso, monga mafuta a mandala amaso.
4, Gelatinaus Wor: Monga maziko a mankhwala a gelatinous kunja kapena mafuta.
5, mankhwala osokoneza bongo: Monga wothandizila kukula, wogulitsa madzi wosunga madzi.

Makampani opanga
1, Zipangizo zamagetsi: monga magetsi a dentimic magetsi, bauxmite Ferrit mphamvu zamagetsi zomata, zitha kugwiritsidwa ntchito ndi 1.2-propylene glycol.
2, Glaze: Kugwiritsa ntchito ngati ceram glaze ndi dongo lokhala ndi enamel, amatha kusintha kugwirira ntchito komanso kusakhazikika.
3, mavalidwe oyenera: Onjezerani matope kapena zida zojambulira, zimatha kusintha mawotchi ndi kusungidwa kwamadzi.

Makampani ena
1 8
2, pepala: ogwiritsidwa ntchito polemba zikopa ndi mafuta a mpweya ndi zinthu zina.
3, chikopa: monga mafuta omaliza kapena okonda zomatira.
4, inki yokhazikitsidwa ndi madzi: yowonjezeredwa ndi inki yokhazikitsidwa ndi madzi, inki, monga wothandizila kukula, wothandizira makanema.
5, Fodya: Monga zomatira fodya wobwezerezedwanso.

Muyezo wa pharmacoeia

Gwero ndi Zokhudza
Izi ndi 2- hydroxypropyl e methyl cellulose. Hydroxypropyl methylcellulose can be divided into four types according to the content of methoxy and hydroxypropyl, namely 1828, 2208, 2906, 2910. The content of each substituted methoxy (-OCH3) and hydroxypropoxy (-OCH2ChohCH3) should comply with the provisions of the attached table.

munthu
Izi ndizoyera kapena zoyera kapena zoyera za granlar; Ower wopanda.
Izi zikufanana ndi zopanda nzeru mu eyathrous ethanol, ether ndi acetone; Kutupa m'madzi ozizira kuti apange yankho lomveka bwino kapena pang'ono.

Kudziwa
. Ikani 2ml ya chubucho mu chubu choyesera, pang'onopang'ono kuwonjezera 1ML ya 0.035% anthraracene sulfurne khoma la chubu, ndikuyiyika kwa mphindi 5.
(2) kuchuluka kwa madzi owoneka bwino pansi pa chizindikiritso (1) kumatsanulidwa pa mbale yagalasi. Pambuyo pa madzi, wosanjikiza wa filimu yolimba imapangidwa.

kufufuza
1, pH
Pambuyo pozizira, sinthani yankho la 100g ndi madzi ndikuyambitsa mpaka utasungunuka kwathunthu. Tsimikizirani molingana ndi lamulo (Zakumapeto ⅵ h, gawo ii wa pharmacopoeia, 2010 Edition). Mtengo wamtengo uyenera kukhala 5.0-8.0.
2, mafayilo
2.0% (g / g) kuyimitsidwa potenga 10.0g ya malonda ndikuwonjezera madzi 90 ℃ Madzi kuti apangitse mawonekedwe a chimbudzi ndi madzi owuma. Kuyimitsidwawo kunakudwitsidwa kwathunthu kwa mphindi 10 mpaka tinthu tating'onoting'ono tomwe timasokonezedwa kwathunthu ndikunyowa. Kuyimitsidwawo kunakhazikika mu madzi oundana ndikupitilizabe kwa mphindi 40 panthawi yozizira. Chingwe chimodzi cha villimeter (NDJ-1 Itha kugwiritsidwa ntchito pa zitsanzo zowoneka bwino kuposa zomwe zimagwiritsidwa ntchito pa 20 ℃ gractia edition). Ngati ma virus olembedwa ali ochepera 600mpha, chidwi chiyenera kukhala 80% ~ 120% ya mamasukidwe olembedwa; Ngati ma virus olembedwa ndi okulirapo kapena ofanana ndi 600mpha netch, umunthu uyenera kukhala 75% mpaka 140% ya mamasukidwe.

3 Zopanda pake za m'madzi
Tengani 1.0g ya malonda, ikani mu chomera, onjezani madzi otentha 100 pa 80-90 ℃, onjezerani madzi oundana, 1 Galasi Yokhazikika yosungunuka yomwe yawuma yomwe yawumitsidwa kuti ithe kunenepa kwambiri pa 105 ℃, ndikuyeretsa obala ndi madzi. Madziwo anali osefedwa mgalasi yopukutira pamwambayo yolimba ndikuuma kuti ikhale yolemetsa pa 105 ℃, yotsalira osaposa 5mg (0,5%).

4 Kuchepetsa thupi
Tengani izi ndikuwumitsa pa 105 ℃ kwa maola awiri, ndipo kunenepa sikungathenso 5.0% (Zakumapeto ⅷ L, Gawo II, Gawo II Eition 2010).

5 zotsalira zotsalira
Tengani 1.0g ya izi ndikuyang'ana molingana ndi lamulo (Zakumapeto ⅷ n, gawo la II la pharmacopoeia 2010% osapitilira 1.5%.

6 Zitsulo Zazikulu
Tengani zotsalira pansi pa inform yotsalira, onani molingana ndi malamulo (njira yachiwiri ya Ebndo), yokhala ndi zitsulo zolemera sizitha kupitirira 20 miliyoni.

Mchere 7 arsenic
Tengani 1.0g ya izi, onjezerani 1.0g calcium hydroxide, onjezerani madzi owumitsa tebuloni (0.0002%).

Khama Lokhutira
1, methoxyl
Methoxy, ethoxy ndi hydroxypropoxy (Zakumapeto VII F, gawo ii, 2010 koloko ya pharmacopoea) idatsimikizika. Ngati njira yachiwiri (njira ya voliyumu) ​​imagwiritsidwa ntchito, kutenga malondawo, muyeso amayeza molondola ndikuyeza malinga ndi lamulo. Mayeso a methoxy (%) amachotsedwa pazinthu za hydroxyprophoroxy ndalama (%) ndi (31/75 × 0.93).
2, hydroxypropoxy
Methoxy, ethoxy ndi hydroxypropoxy (Zakumapeto VII F, gawo ii, 2010 koloko ya pharmacopoea) idatsimikizika. Ngati njira yachiwiri (njira ya voliyumu) ​​imagwiritsidwa ntchito, tengani mankhwala pafupifupi 0.1g, yoyeza molondola, kwezani malingana ndi lamulo, ndikupeza.

Pharmacology ndi toxicology
Hydroxypropyl mealyl cellulose ndi gawo la mealulose methyl ndi gawo la hydroxypropyl ether ether ether, makamaka, imatha kugwiritsidwa ntchito ngati misozi yopanda pake. Limagwirira ntchito ndikuti polymer amatsatira kutsatira malangizo a adsorption, potengera chochitika cha conjunctival mucin, potengera nthawi yochepetsera mucin mucin ndikuwonjezera nthawi yosungiramo misozi. Adsoropption iyi siimadziyimira pawokha kwa yankho ndipo motero amalola kunyowetsa kosatha mphamvu zothetsera mayankho ochepetsa mafayilo. Kuphatikiza apo, kunyowa kwamiyala kumachulukitsidwa ndikuchepetsa mbali ya kulumikizana kwa mwala woyera.

pharmacokinetics
Palibe zambiri za pharmacokinetic zanenedwa kuti zimagwiritsa ntchito izi.

umboni
Kunyowetsani maso osakwanira kubisalira ndikuchotsa mawonekedwe a maso.

Kugwiritsa ntchito
Akuluakulu onse ndi ana amatha kugwiritsa ntchito. 1-2 madontho, katatu patsiku; Kapena monga wotchulidwa ndi dokotala.
Zotsatira zoyipa zimasintha
Nthawi zina zimatha kuyambitsa vuto lofanana ndi kupweteka m'maso, kuwona kwa masoka, kulumikizana kwa cojunctfams yosasunthika kapena kukwiya. Ngati zizindikirizi zake pamwambapa ndizodziwikiratu kapena kulimbikira, siyani kugwiritsa ntchito mankhwalawa ndikupita kuchipatala kuti akambirane.
tawoo

Ophatikizidwa mwa anthu omwe sagwirizana ndi izi.

Zinthu Zofunikira
1. Osakhudza mutu wa botolo loponya kwa eyelid ndi malo ena kuti asayipitsidwe
2. Chonde sangalalani ndi ana
3. Mwezi umodzi utatsegulira botolo, sioyenera kupitiliza kugwiritsa ntchito.
4. Mankhwala a amayi apakati komanso acticting: Palibe malipoti owonongeka kubereka kapena mavuto ena omwe amayambitsidwa ndi hydroxpyupyl celluse m'thupi la munthu adapezeka; Palibe zovuta zomwe zimachitika zomwe zanenedwa m'magulu amtundu wa m`mawere. Chifukwa chake, palibe contransiacachi ndi akazi oyembekezera komanso oyembekezera.
5. Mankhwala a ana: poyerekeza ndi magulu ena a hydroypropyl, meth methylcellulose mwa ana sizimayambitsa zomwe zimachitika. Chifukwa chake, ana ndi akulu amatha kugwiritsa ntchito izi malinga ndi dongosolo lomwelo.
6, mankhwala a okalamba: kugwiritsa ntchito hydroxypropyl meth Momwemo, mankhwala a wodwala akadwala alibe contrandirindi yapadera.
7, Kusungirako: Kusungidwa kwa airtighfic.

Kuchita Chitetezo
Ngozi zaumoyo
Izi ndi zotetezeka komanso zopanda poizoni, zitha kugwiritsidwa ntchito ngati chowonjezera cha chakudya, popanda kutentha, palibe kukwiya khungu ndi mucous membrane kulumikizana. Nthawi zambiri zimawoneka zotetezeka (FDA1985). Kudya kovomerezeka kwa tsiku ndi tsiku ndi 25mg / kg (fao / Ndani 1985). Zida zoteteza ziyenera kuvalidwa pakugwira ntchito.

Zotsatira za chilengedwe
Pewani kuwonongeka kwa mpweya chifukwa cha fumbi likuuluka.
Zowopsa zakuthupi ndi zamankhwala: Pewani kulumikizana ndi magwero amoto, ndikupewa kupanga fumbi yambiri m'malo otsekedwa kuti mupewe zoopsa.
Katundu wogulitsa wotumizidwa
Yang'anirani kutetezedwa ndi dzuwa ku mvula ndi chinyezi, pewani dzuwa mwachindunji, losindikizidwa m'malo owuma.
Chitetezo
S24 / 25: Pewani kulumikizana ndi khungu ndi maso.
Pewani kulumikizana ndi khungu ndi maso.